APE Antibody Pack

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-909	Applications	Species
Zou GM, Yu J, LeBron C, Fu Y. RNAi Knockdown of Ape1 Gene in the Differentiation of Mouse Embryonic Stem Cells Methods Mol. Biol. 2017-07-04 [PMID: 28674806] (Mouse)		Mouse
Zou GM, Lebron C, Fu Y. RNAi knockdown of redox signaling protein Ape1 in the differentiation of mouse embryonic stem cells. Methods Mol Biol 2010-01-01 [PMID: 20686948] (WB, Mouse)	WB	Mouse
Briegert, M, Kaina, B. Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. Cancer Res;67(1):26-31. 2007-01-01 [PMID: 17210680]
Zou, GM et al. Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood;109(5):1917-22. 2007-03-01 [PMID: 17053053]

Array NB100-909

• APE Antibodies
• APE Antibody Pack
• APE Lysates
• APE Proteins