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Hedgehog Signaling Pathway

The Hedgehog pathway is responsible for regulating and coordinating cellular growth and development in the embryo. Under specific time or position-dependent stimuli, cells secrete the hedgehog family ligands (sonic, desert, and indian), whose binding allows the membrane receptors Patched and Smoothened to associate on the primary cilium. This association frees Gli, which translocates to the nucleus and triggers expression of various transcription factors for cell growth. Ultimately, the Hedgehog signaling pathway is fundamental for proper embryo development and defects have been linked to certain types of cancer.
Hedgehog Pathway

Novus Biologicals offers a number of top quality antibodies for the Hedgehog signaling pathway proteins, with some of our most popular included in the table below. Please follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies.

 

Name Catalog# Species Applications
Sonic Hedgehog NBP1-69270 Hu, Mu, Rt, Ca, Ch, Xp, Ze WB, IHC-P, IHC
Desert Hedgehog NBC1-18407 Hu ELISA, PAGE
Indian Hedgehog NB110-57122 Hu, Mu, Rt WB, IHC, IHC-P, IP
Dispatched NB100-1408 Hu ICC/IF, PEP-ELISA
Patched 1 NBP1-71662 Hu WB, ICC/IF
Smoothened 19440002 Hu ELISA, IHC, IHC-P
Smoothened NBP1-71299 Hu, Mu, Rt WB, ELISA
CDON/Cdo NBP1-85700 Hu IHC, IHC-P
CDON/Cdo NBP1-55796 Hu ELISA, ICC/IF
BOC NBP1-00162 Hu, Mu, Bv, Ca WB, PEP-ELISA
KIF7 NBP1-92056 Hu WB, IHC, IHC-P
KIF7 NBP1-46838 Hu WB
Suppressor of Fused NBP1-87384 Hu WB, ICC/IF, IHC, IHC-P
Suppressor of Fused NBP1-28703 Hu IP
Gli1 NBP1-78259 Hu,Mu WB, ICC/IF, IHC, IHC-P
Gli1 NB600-600 Hu, Mu WB, ChIP, ELISA, IHC, IHC-P
Gli2 NBP1-03303 Mu WB, ELISA, IHC, IHC-P
Gli2 NB600-874 Hu, Rt, Mk WB, ELISA, IHC, IHC-P
Gli3 NBP1-89275 Hu ICC/IF, IHC, IHC-P
Gli3 NBP1-55571 Hu, Mu, Rt ELISA, ICC/IF, IHC, IHC-P
Cytokeratin 1 NB100-2756 Hu WB, ICC/IF, IHC, IHC-Fr, IHC-P
GSK3 beta NB100-92035 Hu, Mu, Rt WB, IHC, IHC-P
GSK3 beta NBP1-02156 Hu, Mu, Rt, Sh, Ze WB
Arrestin beta 1 NBP1-64749 Hu WB, ELISA, ICC/IF, IHC, IHC-P
Arrestin beta 2 NBP1-79278 Hu, Mu, Rt, Bv, Ca, Ch, Po, Rb, Xp, Ze WB, IHC-P, IHC
Indian Hedgehog NBP1-59443 Hu, Mu, Rt WB, IHC, IHC-P

Hedgehog Signaling Pathway References

  1. Sahebjam S, et al. The Utility of Hedgehog Signaling Pathway Inhibition for Cancer. Oncologist. 2012 Jul 31. [PMID: 22851551]
  2. Ma HY, et al. HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells. Oncol Lett. 2011 Nov;2(6):1291-1295. [PMID: 22848304].
  3. Choi KS, et al. Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs. Mech Dev. 2012 Jul 25.
    [PMID: 22841806].
  4. Riobo NA. Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol.
    2012 Jul 23. [PMID: 22832232].
  5. Pan JY, Zhou SH. The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease.
    Pharmazie. 2012 Jun;67(6):475-81. [PMID: 22822532].