XRCC1 Antibody

XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA Ligase III-a.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ICC/IF, Immunoprecipitation, WB, Western Blot.

Showing Publications 1 - 5 of 5.

Publications using NBP1-87154	Applications	Species
Gautam A, Fawcett H, Burdova K et al. APE1-dependent base excision repair of DNA photodimers in human cells Molecular cell 2023-10-19 [PMID: 37816354] (ICC/IF, Human) Details: ICC/IF 1:2000 dilution	ICC/IF	Human
Bilkis R, Lake RJ, Cooper KL et al. The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions Nucleic acids research 2023-06-16 [PMID: 37326017] (WB, Human)	WB	Human
Demin A, Hirota K, Tsuda M et al. XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair Mol Cell 2021-06-08 [PMID: 34102106]
Komulainen E, Badman J, Rey S et al. Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures EMBO reports 2021-05-05 [PMID: 33932076]
Wu W, Hill SE, Nathan WJ et al. Neuronal enhancers are hotspots for DNA single-strand break repair Nature 2021-05-20 [PMID: 33767446] (Immunoprecipitation, Western Blot)	Immunoprecipitation, Western Blot

Array NBP1-87154

• XRCC1 Antibodies
• XRCC1 Lysate
• XRCC1 Proteins