GR/NR3C1 Antibody (BuGR2) - BSA Free

Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor. The corresponding gene for the glucocorticoid receptor is NR3C1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Chemotaxis, FLOW, ICC/IF, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB300-731	Applications	Species
Rudak PT, Choi J, Parkins KM et al. Chronic stress physically spares but functionally impairs innate-like invariant T cells Cell Rep 2021-04-14 [PMID: 33852855] Details: Citation using the PE format of this antibody.
Adams RCM, Smith C. In utero Exposure to Maternal Chronic Inflammation Transfers a Pro-Inflammatory Profile to Generation F2 via Sex-Specific Mechanisms Front Immunol. [PMID: 32117231] (ICC/IF, Mouse)	ICC/IF	Mouse
Adams R, Smith C Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny Mediators of Inflammation Aug 25 2019 [PMID: 31582905] (Flow, Mouse) Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny. Mediators Inflamm. 2019-08-25 [PMID: 31582905] (FLOW, Mouse) Details: Citation using the Alexa Fluor 647 version of this antibody.	FLOW	Mouse
Taves MD, Mittelstadt PR, Presman DM et al. Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus Cell Rep 2019-03-26 [PMID: 30917317] (Mouse)		Mouse
Roh Kyung-Baeg, Park Deokhoon, Jung Eunsun et al Inhibitory Effects of Prunella vulgaris L. Extract on 11 beta-HSD1 in Human Skin Cells. Evid Based Complement Alternat Med. 2018-10-04 [PMID: 30402116] (ICC/IF, Human) Details: Citation using the PE version of this antibody.	ICC/IF	Human
Rue L, Banez-Coronel M, Creus-Muncunill J et al. Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels. J. Clin. Invest. 2016-11-01 [PMID: 27721240] (WB, Mouse)	WB	Mouse
Wu JN, Pinello L, Yissachar E et al. Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia. Epigenetics Chromatin 2015-01-01 [PMID: 26633995] (Chemotaxis)	Chemotaxis
Schoenfelder Y, Hiemke C, Schmitt U. Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms. J Neuroendocrinol 2012-05-01 [PMID: 22339976] (Mouse)		Mouse
Harrell JM, Murphy PJ, Morishima Y et al. Evidence for glucocorticoid receptor transport on microtubules by dynein. J Biol Chem. 2004-12-01 [PMID: 15485845]
Viegas LR, Vicent GP, Baranao JL et al. Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4. J Biol Chem. 2004-03-01 [PMID: 14679196]
Lambert JR, Nordeen SK. CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. Mol Endocrinol. 2003-06-01 [PMID: 12637584]
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	1 reviewed by: Shavahn Loux	IHC-P	Equine	02/01/2020	View Summary Application Immunohistochemistry-Paraffin Sample Tested Liver tissue,Liver Species Equine Lot UH286741 Comments Comments ***Bio-Techne Response: This review was submitted through the legacy Novus Innovators Program, reflecting a new species or application tested on a primary antibody.***Tried HIER ph 6 and HIER pH 9 with concentrations as high as 1:200. Never saw any nuclear staining in horse liver; only non-specific background staining.
Enlarge	4 reviewed by: Agnes Villers	WB	Mouse	09/03/2014	View Summary Application Western Blot Sample Tested mouse hippocampal tissue lysate Species Mouse Lot 0K194127
Enlarge	4 reviewed by: Agnes Villers	WB		08/29/2014	View Summary Application Western Blot Lot 0K194127

Array NB300-731

• GR/NR3C1 Antibodies
• GR/NR3C1 ELISA Kits
• GR/NR3C1 Lysates
• GR/NR3C1 Protein