SOD1/Cu-Zn SOD Antibody

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS); also called amyotrophic lateral sclerosis 1 (ALS1 or ALS). ALS is a degenerative disorder of motorneurons in the cortex, brainstem and spinal cord. ALS is characterized by muscular weakness and atrophy beginning in the hands and spreading to the forearms and legs. Muscle fasciculations are commonly visible. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as Lou Gehrig disease after the famous American baseball player who was diagnosed with the disorder. FALS, the familial form of ALS, accounts for about 10% of the cases and is transmitted in an autosomal dominant manner. The mean age at onset of FALS is 45 years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using NBP2-24915	Applications	Species
Noor MI, Rahman MS Roundup® disrupts tissue architecture, attenuates Na+/K+-ATPase expression, and induces protein oxidation/nitration, cellular apoptosis, and antioxidant enzyme expressions in the gills of goldfish, Carassius auratus Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023-07-31 [PMID: 37532112]
Chang YJ, Jenny LA, Li YS et al. CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD Proceedings of the National Academy of Sciences of the United States of America 2023-05-09 [PMID: 37126685]
Martinez-Martel I, Bai X, Batalle G, Pol O New Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice Antioxidants (Basel, Switzerland) 2022-12-01 [PMID: 36552595] (WB, Mouse)	WB	Mouse
Najjar R Raspberry Polyphenols Target Molecular Pathways of Heart Failure Thesis 2023-01-01
F Wei, CJ Neal, TS Sakthivel, Y Fu, M Omer, A Adhikary, S Ward, KM Ta, S Moxon, M Molinari, J Asiatico, M Kinzel, SN Yarmolenko, V San Cheong, N Orlovskaya, R Ghosh, S Seal, M Coathup A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme Bioactive materials, 2022-09-21;21(0):547-565. 2022-09-21 [PMID: 36185749]
Lacy B, Rahman MS Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage and renin attenuation Journal of applied toxicology : JAT 2022-06-13 [PMID: 35698815]
Lacy B, Rahman MS, Rahman MS Potential mechanisms of Na+/K+-ATPase attenuation by heat and pesticides co-exposure in goldfish: role of cellular apoptosis, oxidative/nitrative stress, and antioxidants in gills Environmental science and pollution research international [PMID: 35352221]
Pouso-Vazquez E, Bai X, Batalle G et al. Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice Biochemical pharmacology 2022-03-08 [PMID: 35276215] (WB, Mouse)	WB	Mouse
Carmona-Rodriguez L, Martinez-Rey D, Martin-Gonzalez P et al. Superoxide Dismutase-3 Downregulates Laminin alpha5 Expression in Tumor Endothelial Cells via the Inhibition of Nuclear Factor Kappa B Signaling Cancers 2022-02-26 [PMID: 35267534] (WB, Human)	WB	Human
Pek E, Canbey Goret C, Hacivelioglu S et al. The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study Journal of the Turkish German Gynecological Association 2020-12-04 [PMID: 32500677] (IHC-P, Rat)	IHC-P	Rat
Kwon I, Song W, Jang Y et al. Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice Annals of Hepatology [PMID: 31611063]
Han J, Kim S, Ryu M et al. Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson s Disease Model Oxidative Medicine and Cellular Longevity 2019-08-26 [PMID: 31534621] (WB, Mouse)	WB	Mouse
Mishra P, Paital B, Jena S et al. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NF kappa B/AKT/mTOR/KEAP1 signalling in rat heart Sci Rep 2019-05-15 [PMID: 31092832] (WB, Rat)	WB	Rat
Ghaffari, R;Di Bona, KR;Riley, CL;Richburg, JH; Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis PLoS ONE 2019-04-19 [PMID: 31002737] (WB, Mouse)	WB	Mouse
Millett CE, Phillips BE, Saunders EFH. The Sex-specific Effects of LPS on Depressive-like Behavior and Oxidative Stress in the Hippocampus of the Mouse Neuroscience 2018-12-14 [PMID: 30553795] (WB, Mouse)	WB	Mouse
De Riccardis L, Buccolieri A, Muci M et al. Copper and ceruloplasmin dyshomeostasis in serum and cerebrospinal fluid of multiple sclerosis subjects. Biochim. Biophys. Acta. 2018-03-08 [PMID: 29524632] (WB, Human)	WB	Human
Yao Y, Wang Y, Zhang Y, Liu C. Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways. Lipids Health Dis. 2017-04-13 [PMID: 28407763] (WB, Human)	WB	Human
Bertolo A, Capossela S, Frankl G et al. Oxidative status predicts quality in human mesenchymal stem cells Stem Cell Res Ther Jan 6 2017 [PMID: 28061861] (FLOW, Human). Stem Cell Res Ther. 2017-01-06 [PMID: 28061861] Details: This citation used the FITC version of this antibody.
Sagar S, Kumar P, Behera RR, Pal A. Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells. J. Hazard. Mater. 2014-06-06 [PMID: 24976129] (WB, Mouse) Details: Fig 6: RAW264.7	WB	Mouse
Kumar P, Rao GN, Pal BB, Pal A. Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. Int. J. Biochem. Cell Biol. 2014-06-04 [PMID: 24907397] (WB, Rat) Details: Fig 2B: primary astroglial cells. Catalase was detected below the 72 kDa marker.	WB	Rat
Show All 20 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Bovine	09/23/2020	View Summary Application Western Blot Sample Tested ocular fluid Species Bovine Lot 03253462c2b-3 Comments Comments use at a dilution of 1:1000
Enlarge	5 reviewed by: Verified Customer	WB	Human	09/23/2020	View Summary Application Western Blot Sample Tested ocular fluid Species Human Lot 03253462c2b-3 Comments Comments use at dilution 1:1000
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	01/12/2017	View Summary Application Western Blot Sample Tested Liver Species Mouse Lot 03253462C2B Comments Comments N/A

Array NBP2-24915

• SOD1/Cu-Zn SOD Antibodies
• SOD1/Cu-Zn SOD Antibody Pair
• SOD1/Cu-Zn SOD ELISA Kits
• SOD1/Cu-Zn SOD Lysate
• SOD1/Cu-Zn SOD Proteins