Researchers have long wondered how developing tissues and organs are signaled to stop growing upon reaching maturity. The Hippo (or SWH) signaling pathway has been shown to be responsible for controlling organ growth and size by limiting cell proliferation and promoting apoptosis. At low cell densities, the co-activators YAP/TAZ induce the expression of transcription factors that lead the pathway toward cell proliferation. However at higher cell densities, membrane-bound regulators trigger YAP/TAZ phosphorylation, thereby preventing them from entering the nucleus to induce the pro-growth transcription factors. Mutations of the Hippo protein lead to overgrowth that is similar to the unchecked cell proliferation found in tumors.
Novus Biologicals offers a number of top quality antibodies for the HIPPO signaling pathway proteins, with some of our most popular included in the table below. Please feel follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies.
HIPPO Signaling Pathway Antibodies for Human Samples
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HIPPO Signaling Pathway References