APE Products

Description

DNA-(apurinic or apyrimidinic site) lyase, also known as APE1 or APEX1, is a multifunctional mammalian proteins responsible for the cellular response to oxidative stress. Specifically, APE-1 both functions in the DNA base excision repair pathway and regulates the redox of transcriptional factors.

For DNA repair, APE1 functions as a mammalian apurinic/apyrimidinic (AP) endodeoxyribonuclease responsible for the repair of AP sites in DNA lesions induced by oxidative and alkylating agents.

APEX1 also exerts a reversible nuclear redox activity to regulate the DNA binding affinity and the activity of transcriptional factors by regulating the redox status of their DNA-binding domains.

APE1 antibodies are useful for studies on both DNA repair and transcriptional regulation.

Bioinformatics

Entrez	11792 Mouse 328 Human 79116 Rat
Uniprot	AAH02338 Human AAH02338 Human AAH19291 Human AAH19291 Human NM_001641 Human NM_001641 Human NM_080648 Human NM_080648 Human NP_001632 Human NP_001632 Human NP_001632.2 Human NP_001632.2 Human NP_001632.2 Human NP_542379.1 Human NP_542380 Human NP_542380 Human NP_542380.1 Human P27695 Human P27695 Human
Product By Gene ID	328
Alternate Names	AP endonuclease 1 APE APE1 APE-1 APEAPEX nuclease (multifunctional DNA repair enzyme) APENAP endonuclease class I APEX deoxyribonuclease (apurinic or apyrimidinic) APEX nuclease (multifunctional DNA repair enzyme) 1 APEX nuclease Apurinic-apyrimidinic endonuclease 1 APXAP lyase DNA-(apurinic or apyrimidinic site) lyase EC 3.1 EC 4.2.99.18 HAP1apurinic/apyrimidinic (abasic) endonuclease multifunctional DNA repair enzyme protein REF-1 redox factor 1 Redox factor-1 REF1 apurinic/apyrimidinic exonuclease REF-1

Research Areas for APE

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Base Excision Repair
Cancer
Core ESC-Like Genes
DNA Repair
Stem Cell Markers