CCR2 Antibody - BSA Free

CCR2 is a major chemokine receptor expressed on monocytes and its activation through its ligands MCP1, MCP2, MCP3 and MCP4 (systematic names CCL2, CCL8, CCL7 and CCL13, respectively) stimulates the migration of monocytes across the vascular wall into tissues wherein they facilitate chronic inflammation. CCR2 is a member of GPCR1 family and is up-regulated by CREB3. It is a multi-pass membrane protein found in cell membrane, and besides monocytes, it is also found on other cell types like NK cells, macrophages, immature dendritic cells, gamma delta T cells, and activated T cells (including Th17 cells). There are two alternatively spliced forms of CCR2: CCR2A - the major isoform expressed by mononuclear cells and vascular smooth muscle cells; and CCR2B - expressed predominantly by monocytes and activated NK cells. CCR2 has both pro-inflammatory (mediated by APC and T cells) and anti-inflammatory (mediated by regulatory T cells) activities. Besides inflammation, it has been implicated several pathologies including HIV-1/AIDS, autoimmune disorders (psoriasis, rheumatoid arthritis, and multiple sclerosis), pulmonary diseases (asthma, COPD), vascular disease and cancer (prostate cancer).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Porcine.

We have publications tested in 6 applications: B/N, FLOW, IF/IHC, IHC-Fr, IHC-P, Immunocytochemistry/ Immunofluorescence.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP1-48338	Applications	Species
Elizondo-Benedetto S, Sastriques-Dunlop S, Detering L et al. Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms medRxiv : the preprint server for health sciences 2023-11-07 [PMID: 37986880] (IHC-P, Rat)	IHC-P	Rat
Deng S, Zhou F, Wang F et al. C5a enhances V?1 T cells recruitment via the CCL2-CCR2 axis in IgA nephropathy International immunopharmacology 2023-10-18 [PMID: 37862725] (IHC-P, Human) Details: HMC Stimulation	IHC-P	Human
Kim S, Oh D, Choi H et al. The effect of C-C motif chemokine ligand 2 supplementation on in vitro maturation of porcine cumulus-oocyte complexes and subsequent developmental competence after parthenogenetic activation Frontiers in veterinary science 2023-03-13 [PMID: 36992978] (Immunocytochemistry/ Immunofluorescence, Porcine)	Immunocytochemistry/ Immunofluorescence	Porcine
Chakrabarti J, Dua-Awereh M, Schumacher M et al. Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium NPJ Regenerative medicine 2022-01-12 [PMID: 35022438] (IF/IHC, Mouse)	IF/IHC	Mouse
Lee SA, Kim D, Min C Et al. Phagocyte Chemoattraction Is Induced through the Mcp-1-Ccr2 Axis during Efferocytosis Cells 2021-11-10 [PMID: 34831339] (B/N, Human)	B/N	Human
B�l�kbas DA, Datz S, Meyer-Schwickerath C et al. Organ-restricted vascular delivery of nanoparticles for lung cancer therapy Advanced Therapeutics 2021-04-22 [PMID: 33884290] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Baba T, Miyazaki D, Inata K et al. Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration Elife 2020-05-05 [PMID: 32366355] (IF/IHC, Mouse) Details: Citation using the DyLight 550 format of this antibody.	IF/IHC	Mouse
Wolf M, Clay S. M, et al. MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2. Sci Rep 2019-08-09 [PMID: 31399604] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Lang SC, Harre U, Purohit P et al. Neurodegeneration Enhances the Development of Arthritis. J. Immunol. 2017-02-10 [PMID: 28188247] (FLOW, Mouse)	FLOW	Mouse
Carlson S, Helterline D, Asbe L et al. Cardiac macrophages adopt profibrotic/M2 phenotype in infarcted hearts: Role of urokinase plasminogen activator. J Mol Cell Cardiol 2016-06-01 [PMID: 27262672] (FLOW, Mouse)	FLOW	Mouse
Zhang L, Zhang S, Yao J et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature 2015-11-05 [PMID: 26479035]
Show All 11 Publications. Collapse Publications.

Array NBP1-48338

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins