MyD88 Antibody - BSA Free

MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bovine, Chicken.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC, IHC-P, WB.

Showing Publications 1 - 10 of 24. Show All 24 Publications. Collapse Publications.

Publications using NB100-56698	Applications	Species
Yoshikawa T, Takeichi T, Hirabayashi T et al. IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice Research Square 2023-02-02 (IHC, Mouse)	IHC	Mouse
Chen J, Wang X, Li S et al. Effect of Echinacea Purpurea  (L.) Moench And its Extracts on the Immunization Outcome of Avian Influenza Vaccine in Broilers RRSN 2023-09-21 [PMID: 37839770] (WB, Chicken)	WB	Chicken
Shen J, Yang F, Wang G et al. Paeoniflorin alleviates inflammation in bovine mammary epithelial cells induced by Staphylococcus haemolyticus through TLR2/NF-?B signaling pathways Research in veterinary science 2023-03-01 [PMID: 36796241] (WB, Bovine)	WB	Bovine
Huang D, Wang P, Chen J et al. Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling Frontiers in Immunology 2022-11-01 [PMID: 36389716]
Arigela CS, Nelli G, Gan SH Et al. Bitter Gourd Honey Ameliorates Hepatic and Renal Diabetic Complications on Type 2 Diabetes Rat Models by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms Foods (Basel, Switzerland) 2021-11-20 [PMID: 34829154] (IF/IHC, Rat)	IF/IHC	Rat
Vendidandala NR, Yin TP, Nelli G Et al. Gallocatechin silver nanoparticle impregnated cotton gauze patches enhance wound healing in diabetic rats by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-kappa B pathways Life sciences 2021-10-06 [PMID: 34624322] (IHC-P, Rat)	IHC-P	Rat
Wladis EJ, Arunachalam T, LaJoie JE et al. Myeloid differentiation factor 88 expression in eyelid specimens of rosacea Orbit (Amsterdam, Netherlands) 2021-03-31 [PMID: 33789561] (IF/IHC, Human)	IF/IHC	Human
Hong Y, Lee J, Vu TH et al. Exosomes of lipopolysaccharide-stimulated chicken macrophages modulate immune response through the MyD88/NF-kappa B signaling pathway Dev Comp Immunol 2020-10-25 [PMID: 33115603]
Ji S, Xiao J, Liu J, Tang S Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway Stem Cells Int. 2019-10-15 [PMID: 31737079] (WB, Rat)	WB	Rat
Pham TT, Ban J, Lee K et al. MicroRNA gga-miR-10a-mediated transcriptional regulation of the immune genes in necrotic enteritis afflicted chickens Dev. Comp. Immunol. 2019-08-19 [PMID: 31437523] (WB, Chicken)	WB	Chicken
Russell Marsha S, Creskey Marybeth, Muralidharan Abenaya et al. Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine. Frontiers in Immunology 2019-03-29 [PMID: 30984178] (IHC-P, Rat)	IHC-P	Rat
Ng YC, Chung WC, Kang HR et al. A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kB-mediated innate immunity against DNA virus infection Nucleic Acids Res. 2018-08-20 [PMID: 30137501] (WB, Mouse)	WB	Mouse
Davis S, Cirone A M et al. Phagocytosis-mediated M1 activation by chitin but not by chitosan. Am J Physiol Cell Physiol 2018-01-07 [PMID: 29719169] (WB, Mouse)	WB	Mouse
Popiolek-Barczyk K, Piotrowska A, Makuch W, Mika J. Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.. Neural Plast. 2017-06-02 [PMID: 28573049] (WB, Rat)	WB	Rat
Shi M, Zhang Y, Liu L et al. MAP1S regulates the phagocytosis of bacteria and TLR signaling. J. Biol. Chem. 2015-11-12 [PMID: 26565030] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Dumas A, Amiable N, de Rivero Vaccari JP et al. The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1B Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis. PLoS Pathog. 2014-05-01 [PMID: 24875775] (WB, Mouse) Details: Fig 4c, d: peritoneal leukocytes	WB	Mouse
Li Y, Zhang H, Zhang H et al. Toll-like receptor 4 signaling contributes to paclitaxel-induced peripheral neuropathy. J Pain 2014-04-19 [PMID: 24755282] (Rat) Details: Spinal cord: WB (Figs 1C, 2A, 8A), MyD88 was detected at ~31kDa		Rat
Harvey SA, Dangi A, Tandon A et al. The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation. PLoS One 2013-12-09 [PMID: 24349206] (WB, Rat)	WB	Rat
Pathak SK, Basu S, Basu KK et al. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nat Immunol. 2007-06-01 [PMID: 17486091] (WB)	WB
Palladino M A, Johnson T A, Gupta R et al. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod. 2007-06-01 [PMID: 17314314] (WB, Rat)	WB	Rat
Saccani A, Schioppa T, Porta C et al. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 2006-12-01 [PMID: 17145890] (WB, Human) Details: WB (human peritoneal exudate cells and tumor-associated macrophages), Fig. 1C.	WB	Human
Macagno A, Molteni M, Rinaldi A et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006-06-12 [PMID: 16717116]
Srivastava MD, Srivastava BI. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005-07-01 [PMID: 15927677] Details: IF/ICC in SRIK-NKL cells: TLR2 (IMG416), TLR4 (IMG-417), TLR7 (IMG-581), and TLR9 (IMG-305).
Jeyaseelan S, Manzer R, Young SK et al. Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium. Am J Respir Cell Mol Biol. 2005-06-01 [PMID: 15778492]
Show All 24 Publications. Collapse Publications.

Array NB100-56698

• MyD88 Antibodies
• MyD88 ELISA Kit
• MyD88 Inhibitor
• MyD88 Lysate
• MyD88 Proteins
• MyD88 ELISA