NFkB p105/p50 Antibody (2J10D7) - BSA Free

Principal Names: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); DNA-binding factor KBF1; EBP-1; NFKB-p50; Official Gene Symbol: NFKB1 Gene ID: 4790 (Human) Gene Map Locus: 4q24 (human) NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat, Rabbit.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 5 of 5.

Publications using NB100-56583	Applications	Species
Apriawan T, Widjiati W, Utomo DN et al. Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-kappa B pathway: An experimental study with Oryctolagus cuniculus rabbits Surgical neurology international 2022-04-15 [PMID: 35509533] (IF/IHC, Rabbit)	IF/IHC	Rabbit
Duran Y, Karaboga I Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats Biotech Histochem 2019-12-18 [PMID: 31850807] (IF/IHC, Rat)	IF/IHC	Rat
Sikorski K, Mehta A et al. A high-throughput pipeline for validation of antibodies. Nat Methods 2018-01-11 [PMID: 30377371] (Human) Details: Antibody validation based on denaturing gel electrophoresis of biotinylated cell lysates (PAGE) followed by mass spectrometry (MS) and antibody array analysis (MAP).		Human
Santhi WS, Sebastian P, Varghese BT et al. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. Exp Mol Pathol. 2006-10-01 [PMID: 16822500] Details: Products used (human): 1. IkBa [IMG-127A]: IHC paraffin (normal oral mucosa, leukoplakia, and oral cancer), Fig. 1 IHC paraffin analysis (normal oral mucosa, leukoplakia, and oral cancer), Fig. 2 IHC paraffin (oral cancer: primary tumor, surgical margin,

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-P	Rabbit	10/02/2017	View Summary Application Immunohistochemistry-Paraffin Sample Tested aorta artery Species Rabbit Lot 7341-1P160201 Comments Comments Antigen Retrieval: pressure cooker with solution Trilogy TM (Cell Marque ref: 920P-07). Antibody dilution: 0.07ug/mL (diluted 1/4000). Secondary antibody: anti-mouse histofine ( Nisherei Bioscience Inc. ref: 414131F). Development: DAB (Dako ref: K346811-2) and counterstained with Hematoxylin.

Array NB100-56583

• NFkB p105/p50 Antibodies
• NFkB p105/p50 Kit
• NFkB p105/p50 Lysate
• NFkB p105/p50 Proteins