MyD88 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Myeloid Differentiation primary response protein 88 (MyD88) is a 296 amino acid, 34 kDa, ubiquitously expressed, cytoplasmic adaptor protein involved in the signaling of TLR and IL-1 R family members. MyD88 contains an N-terminal death domain and a C-terminal Toll/IL-1 R (TIR) domain. Each domain seems to participate in protein-protein interactions, as the death domain is inactive. Upon Toll receptor ligation, MyD88 is recruited to the receptor and initiates a signaling cascade that results in NK kappa B and JNK activation. The amino acid sequence of mouse MyD88 is 93% identical to that of rat MyD88.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 5 applications: Co-Immunoprecipitation, ICC, Immunoprecipitation, Proximity Ligation Assay (PLA), Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using AF3109	Applications	Species
Lopez, AG;Chirasani, VR;Balan, I;O'Buckley, TK;Adelman, MR;Morrow, AL; Novel Inhibitory Actions of Neuroactive Steroid [3?,5?]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling Biomolecules 2024-11-13 [PMID: 39595617] (Co-Immunoprecipitation, Rat)	Co-Immunoprecipitation	Rat
Pereira, M;Ramalho, T;Andrade, WA;Durso, DF;Souza, MC;Fitzgerald, KA;Golenbock, DT;Silverman, N;Gazzinelli, RT; The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection Cell reports 2024-02-15 [PMID: 38367238] (Western Blot, Mouse)	Western Blot	Mouse
P Kalantari, I Shecter, J Hopkins, A Pilotta Go, Y Morales, BF Harandi, S Sharma, MJ Stadecker The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology Proceedings of the National Academy of Sciences of the United States of America, 2023-03-21;120(13):e2211047120. 3/21/2023 [PMID: 36943884]
M Pereira, DF Durso, CE Bryant, EA Kurt-Jones, N Silverman, DT Golenbock, RT Gazzinelli The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways Cell Reports, 2022-08-16;40(7):111225. 2022-08-16 [PMID: 35977521] (Immunoprecipitation, Western Blot, Mouse)	Immunoprecipitation, Western Blot	Mouse
CS Indralinga, AK Gutierrez-, SC Johns, T Tsui, DT Cannon, MM Fuster, TD Bigby, PA Jennings, EC Breen IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice Physiological Reports, 2022-02-01;10(3):e15185. 2022-02-01 [PMID: 35150208] (Western Blot, Mouse)	Western Blot	Mouse
Arshiya Parveen, Kyle R. Bohnert, Meiricris Tomaz Tomaz da Silva, Yefei Wen, Raksha Bhat, Anirban Roy et al. MyD88‐mediated signaling intercedes in neurogenic muscle atrophy through multiple mechanisms The FASEB Journal 8/1/2021 [PMID: 34325487]
Rafael Deliz-Aguirre, Fakun Cao, Fenja H.U. Gerpott, Nichanok Auevechanichkul, Mariam Chupanova, YeVin Mun et al. MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling Journal of Cell Biology 7/5/2021 [PMID: 33956941]
M Li, H Wang, W Li, XG Xu, Y Yu Macrophage activation on "phagocytic synapse" arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit Science Advances, 2020-12-02;6(49):. 2020-12-02 [PMID: 33268354] (ICC, Mouse)	ICC	Mouse
Olivia Majer, Bo Liu, Lieselotte S. M. Kreuk, Nevan Krogan, Gregory M. Barton UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity Nature 11/14/2019 [PMID: 31546246]
JK Dowling, ME Tate, NM Bourke, N Bitto, MA Lauterbach, S Cheung, T Ve, B Kobe, D Golenbock, A Mansell The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses J. Immunol., 2019-02-20;0(0):. 2019-02-20 [PMID: 30787108] (Immunoprecipitation, Proximity Ligation Assay (PLA), Mouse)	Immunoprecipitation, Proximity Ligation Assay (PLA)	Mouse
D De Nardo, KR Balka, Y Cardona Gl, VR Rao, E Latz, SL Masters Interleukin 1 receptor-associated kinase 4 (IRAK4) plays a dual role in Myddosome formation and Toll-like receptor signalling J. Biol. Chem., 2018-08-03;0(0):. 2018-08-03 [PMID: 30076215] (Western Blot, Mouse)	Western Blot	Mouse
A Javmen, H Szmacinski, JR Lakowicz, VY Toshchakov Blocking TIR Domain Interactions in TLR9 Signaling J. Immunol., 2018-06-18;0(0):. 2018-06-18 [PMID: 29914886] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Randall J. Platt, Sidi Chen, Yang Zhou, Michael J. Yim, Lukasz Swiech, Hannah R. Kempton et al. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling Cell 10/9/2014 [PMID: 25263330]
Schenten D, Nish S, Yu S, Yan X, Lee H, Brodsky I, Pasman L, Yordy B, Wunderlich F, Bruning J, Zhao H, Medzhitov R Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity, 2014-01-16;40(1):78-90. 2014-01-16 [PMID: 24439266] (Western Blot, Mouse)	Western Blot	Mouse
Cole LE, Shirey KA, Barry E, Santiago A, Rallabhandi P, Elkins KL, Puche AC, Michalek SM, Vogel SN Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect. Immun., 2007-05-21;75(8):4127-37. 2007-05-21 [PMID: 17517865] (ICC, Mouse)	ICC	Mouse
Show All 15 Publications. Collapse Publications.

Array AF3109

• MyD88 Antibodies
• MyD88 ELISA Kit
• MyD88 Inhibitor
• MyD88 Lysate
• MyD88 Proteins
• MyD88 ELISA