IKK beta Antibody

IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta (3). Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response (4). Additionally, IKK-beta activity can also be regulated by MEKK-1 (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NBP1-32258	Applications	Species
Cheshenko N, Bonanno JB, Hoffmann HH et al. Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2 Communications biology 2022-10-16 [PMID: 36245045]
Cheshenko N, Pierce C, Herold BC. Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry PLoS Pathog. 2018-01-01 [PMID: 29293671]

Array NBP1-32258

• IKK beta Antibodies
• IKK beta ELISA Kits
• IKK beta Lysate
• IKK beta Proteins