TRAF-2 Antibody

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor super families and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. TRAF2 is typically described as a 501 amino acid protein, GenBank no. NP_066961.2. However, various TRAF2 isoforms have been described. Therefore, the molecular weight of TRAF2 detected by Western blot may vary depending on isoforms expressed.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ICC/IF, IHC-P, IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-56173	Applications	Species
D0ppler H, Liou GY, Storz P. Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. PLoS One. 2013-01-01 [PMID: 23301098] (WB) Details: IMGENEX product cited: IMG-5760 TRAF2. WB: pancreatic cell lines and TRAF2-transfected HEK293 cells (multiple figures). IP/WB: TRAF2 was IP'd with a different TRAF2 antibody and then western blotted with IMG-5760 (Fig S1). IHC (P): Pancreatic ductal adeno	WB
D'Agostino L, Giordano A. A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma Oncotarget 2011-12-01 [PMID: 22170762] (WB, IP, ICC/IF, Human)	WB, IP, ICC/IF	Human
Zapata JM, Krajewska M, Krajewski S et al. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol. 2000-11-01 [PMID: 11046039] (IHC-P, WB) Details: WB: Figs 1, 2, 4, 5; IHC-paraffin: Fig 3.	IHC-P, WB

Array NB100-56173

• TRAF-2 Antibodies
• TRAF-2 Lysate
• TRAF-2 Proteins