Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IP, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Simple Western, Flow, GS, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Simple Western, DB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC, Ctrl
Species: Hu
Applications: AC
Description
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli (9). Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo (9).
Bioinformatics
Entrez |
Mouse Human Rat |
Uniprot |
Human Human Human Human Human Human Human Human |
Product By Gene ID |
3551 |
Alternate Names |
- EC 2.7.11
- EC 2.7.11.10
- I-kappa-B kinase 2
- I-kappa-B-kinase beta
- IkBKB
- IKK2FLJ38368
- IKK-B
- IKK-betaFLJ36218
- IKKBFLJ40509
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
- inhibitor of nuclear factor kappa-B kinase subunit beta
- MGC131801
- NFKBIKBFLJ33771
- Nuclear factor NF-kappa-B inhibitor kinase beta
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