IKK beta Antibody (10A9B6) - BSA Free

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli. Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: EMSA, ICC/IF, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-56513	Applications	Species
Paul S, Traver MK, Kashyap AK et al. T Cell Receptor Signals to NF-kB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-Ikk Signalosome. Sci Signal. 2014-05-14 [PMID: 24825920] (ICC/IF, Mouse) Details: D10 mouse T-helper cells, Fig S1B	ICC/IF	Mouse
Bakkar N, Ladner K, Canan BD et al. IKKa and alternative NF-kB regulate PGC-1B to promote oxidative muscle metabolism. J Cell Biol. 2012-02-20 [PMID: 22351927]
Yang Gong, Rosen Daniel G, Liu Guangzhi et al. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res. 2010-08-01 [PMID: 20505188] (WB)	WB
Tare Nadine, Li Hongli, Morschauser Andrew et al. KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathways. Exp Cell Res. 2010-09-10 [PMID: 20406635] (WB, Human)	WB	Human
Monsalve Eva, Ruiz-Garcia Almudena, Baladron Victoriano et al. Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity. Eur J Immunol. 2009-09-01 [PMID: 19662631] (EMSA)	EMSA
Scott MJ, Billiar TR. Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem. 2008-10-24 [PMID: 18701460] Details: 1. MyD88 (IMG-2005): MyD88 peptide inhibition (mouse WT hepatocytes), Figs. 4A,D. 2. TIRAP (IMG-2006): TIRAP peptide inhibition (mouse WT hepatocytes), Figs. 4B,D; 5B; 6E.
Lamothe B, Campos AD, Webster WK et al. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J Biol Chem. 2008-09-05 [PMID: 18617513]
Vacca Alessandra, Felli Maria Pia, Palermo Rocco et al. Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J. 2006-03-08 [PMID: 16498412] (Mouse)		Mouse
Fitzgerald KA, McWhirter SM, Faia KL et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003-05-01 [PMID: 12692549] (WB)	WB

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-Fr	Mouse	08/17/2021	View Summary Application Immunohistochemistry-Frozen Sample Tested mouse skin Species Mouse Lot 10A9B6 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.

Array NB100-56513

• IKK beta Antibodies
• IKK beta ELISA Kits
• IKK beta Lysate
• IKK beta Proteins