HIF-2 alpha/EPAS1 Antibody - BSA Free

Hypoxia contributes to the pathophysiology of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease (1). In cancer, and particularly solid tumors, hypoxia plays a critical role in the regulation of genes involved in stem cell renewal, epithelial to mesenchymal transition (EMT), metastasis and angiogenesis. In the tumor microenvironment (TME), hypoxia influences the properties and function of stromal cells (e.g., fibroblasts, endothelial and immune cells) and is a strong determinant of tumor progression (2,3).

HIF-1 or hypoxia inducible factor 1, is a transcription factor commonly referred to as a "master regulator of the hypoxic response" for its central role in the regulation of cellular adaptations to hypoxia. Similarly, HIF-2 alpha plays a role in cellular responses to hypoxia, but whereas HIF-1 alpha is ubiquitously expressed, HIF-2 alpha is predominantly expressed in the vascular endothelium at embryonic stages and after birth in select cells and tissue types (e.g., fibroblasts, hepatocytes and myocytes at 96kDa) (4). Following a similar mechanism to HIF-1 alpha, HIF-2 alpha is stabilized under hypoxic conditions by the formation of a heterodimer with an ARNT/HIF-1 beta subunit. Stable HIF-2 alpha-ARNT/HIF-1 beta heterodimers engage p300/CBP in the nucleus for binding to hypoxic response elements (HREs), inducing transcription, and thus regulation of genes (e.g., EPO, VEGFA). HIF-1 predominantly transactivates genes involved in glycolytic control and pro- apoptotic genes (e.g., LDHA and BNIP3), and HIF-2 regulates the expression of genes involved in invasion and stemness (e.g., MMP2, and OCT4). Common gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5).

The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under normoxic conditions. This process is mediated by oxygen-sensing enzymes, prolyl hydroxylase domain enzymes (PHDs), which catalyze the hydroxylation of key proline residues (Pro-405 and Pro-531) within the oxygen-dependent degradation domain of HIF-2 alpha (5). Once hydroxylated, HIF-2 alpha binds the von Hippel-Lindau tumor suppressor protein (pVHL) for subsequent ubiquitination and proteasomal degradation (5,6).

References

1. Semenza, G. L., Agani, F., Feldser, D., Iyer, N., Kotch, L., Laughner, E., & Yu, A. (2000). Hypoxia, HIF-1, and the pathophysiology of common human diseases. Advances in Experimental Medicine and Biology.

2.Muz, B., de la Puente, P., Azab, F., & Azab, A. K. (2015). The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia. https://doi.org/10.2147/hp.s93413

3. Huang, Y., Lin, D., & Taniguchi, C. M. (2017). Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Science China Life Sciences. https://doi.org/10.1007/s11427-017-9178-y

4. Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003). Differential Roles of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in Hypoxic Gene Regulation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.23.24.9361-9374.2003

5. Koh, M. Y., & Powis, G. (2012). Passing the baton: The HIF switch. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2012.06.004

6. Koyasu, S., Kobayashi, M., Goto, Y., Hiraoka, M., & Harada, H. (2018). Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Cancer Science. https://doi.org/10.1111/cas.13483

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 9 confirmed species: Human, Mouse, Rat, Bat, Hamster, Rabbit, Reptile, Sheep, Zebrafish.

We have publications tested in 21 applications: B/N, ChIP, Chemotaxis, Chip Cytometry, CoIP, ELISA, FLOW, Func, GS, IB, ICC, ICC/IF, IF/IHC, IHC, IHC-Fr, IHC-P, IP, In Vivo, KD, KO, WB.

Showing Publications 1 - 10 of 822. Show All 822 Publications. Collapse Publications.

Publications using NB100-122	Applications	Species
Siyong Peng, Yingbo Guo, Marie Irondelle, Abigail Mazzu, Michel Kahi, Paula Ferreira Montenegro, Frédéric Bost, Nathalie M. Mazure The marine-derived HIF-1 alpha inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes Cellular & Molecular Biology Letters 2024-07-08 [PMID: 38978018]
Kenneth K. Y. Ting, Pei Yu, Riley Dow, Hisham Ibrahim, Saraf Karim, Chanele K. Polenz, Daniel A. Winer, Minna Woo, Jenny Jongstra-Bilen, Myron I. Cybulsky Cholesterol accumulation impairs HIF-1 alpha -dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway Scientific Reports 2024-05-15 [PMID: 38750095]
Chan D.K. Nguyen, Benjamín A. Colón-Emeric, Shigekazu Murakami, Mia N.Y. Shujath, Chunling Yi PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer Cell reports 2024-06-28 [PMID: 38691454]
Sebastian Billig, Marc Hein, Celine Kirchner, David Schumacher, Moriz Aljoscha Habigt, Mare Mechelinck, Dieter Fuchs, Uwe Klinge, Alexander Thei beta en, Christian Beckers, Christian Bleilevens, Rafael Kramann, Moritz Uhlig Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury. Biomedicines 2024-04-16 [PMID: 38672230]
Milankumar Prajapati, Jared Z. Zhang, Lauren Chiu, Grace S. Chong, Courtney J. Mercadante, Heather L. Kowalski, Bradley Delaney, Jessica A. Anderson, Shuling Guo, Mariam Aghajan, Thomas B. Bartnikas Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency JCI Insight 2024-04-23 [PMID: 38652538]
Jacinta H. Martin, Ilana R. Bernstein, Jess M. Lyons, Ariel R. Brady, Nishani S. Mabotuwana, Simone J. Stanger, Camila Salum De Oliveira, Katerina B. Damyanova, Brett Nixon, Tessa Lord EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary Scientific Reports 2024-04-16 [PMID: 38627575]
Nicholas D Nolan, Xuan Cui, Brian M Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F Hu, Laura A Jenny, Chyuan-Sheng Lin, Daniel T Hass, Jianhai Du, James B Hurley, Stephen H Tsang CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa. Cell reports. Medicine 2024-04-19 [PMID: 38518771]
Jaehyeon Jeong, Byeong-Hee Kang, Sangmin Ju, Na Yeon Park, Deukyeong Kim, Ngoc Thi Bao Dinh, Jeongho Lee, Chang Yun Rhee, Dong-Hyung Cho, Hangeun Kim, Dae Kyun Chung, Heeyoun Bunch Lactiplantibacillus plantarum K8 lysates regulate hypoxia-induced gene expression Scientific Reports 2024-03-15 [PMID: 38491188]
Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti Low nuclear expression of HIF ‐hydroxylases PHD2 / EGLN1 and PHD3 / EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma Cancer Medicine 2024-02-24 [PMID: 38400673]
Jenna Kerry, Erin J Specker, Morgan Mizzoni, Andrea Brumwell, Leslie Fell, Jenna Goodbrand, Michael N Rosen, James Uniacke Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival. FEBS letters 2024-03-12 [PMID: 38281767]
Yong Hwan Kim, Na Yeon Park, Doo Sin Jo, Ji-Eun Bae, Joon Bum Kim, Kyuhee Park, Kwiwan Jeong, Pansoo Kim, Eunbyul Yeom, Dong-Hyung Cho Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1 alpha in HeLa Cells. Molecules (Basel, Switzerland) 2024-01-24 [PMID: 38257395]
Wittig, F;Koch, F;Pannenberg, L;Bekeschus, S;Ramer, R;Hinz, B; ?-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells-Possible Role of VEGF Downregulation International journal of molecular sciences 2024-01-09 [PMID: 38255884]
Kelsey G DeFrates, Elaine Tong, Jing Cheng, Ellen Heber-Katz, Phillip B Messersmith A Pro-Regenerative Supramolecular Prodrug Protects Against and Repairs Colon Damage in Experimental Colitis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024-01-21 [PMID: 38247203]
Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D Korman, Sara O Vargas, Joseph C Wu, Kurt R Stenmark, Vinicio de Jesus Perez, Mark R Nicolls, Benjamin A Raby, Ke Yuan Pericytes contribute to pulmonary vascular remodeling via HIF2 alpha signaling EMBO Reports 2024-01-19 [PMID: 38243138]
Ayaka Nakai, Deokho Lee, Chiho Shoda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Toshihide Kurihara Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu ( Myrciaria dubia ) Treatment in ARPE-19 and Fetal Human RPE Cells Journal of Ophthalmology 2023-01-01 [PMID: 38187496]
Bernstein I, Nixon B, Lyons J et al. The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions iScience 2023-12-01 [PMID: 38077147] (IHC, Mouse) Details: Mouse testis	IHC	Mouse
Contenti J, Guo Y, Larcher M et al. HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma bioRxiv : the preprint server for biology 2023-10-20 [PMID: 37905067] (WB, Human)	WB	Human
Henning Y, Willbrand K, Larafa S et al. Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1? under normoxia Cell death discovery 2023-10-25 [PMID: 37880219] (WB, Human)	WB	Human
Felix Wittig, Liza Pannenberg, Rico Schwarz, Sander Bekeschus, Robert Ramer, Burkhard Hinz, Domenico Ribatti, Pablo Martín-Vasallo Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells Cells 2023-09-22 [PMID: 37830546]
Zhang F, Zhang B, Wang Y et al. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption Nature 2023-10-01 [PMID: 37794190] (WB, Mouse)	WB	Mouse
Ting KKY, Yu P, Dow R et al. Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1? to the Nrf2 Pathway Journal of immunology (Baltimore, Md. : 1950) 2023-09-27 [PMID: 37756544]
Alexander KA, Yu R, Skuli N et al. Nuclear speckles regulate HIF-2? programs and correlate with patient survival in kidney cancer bioRxiv : the preprint server for biology 2023-09-16 [PMID: 37745397] (WB, ChIP, Mouse)	WB, ChIP	Mouse
Ht Hall C, Lanis JM, Dowdell AS et al. Fundamental role for the creatine kinase pathway in protection from murine colitis Mucosal immunology 2023-09-14 [PMID: 37716510]
Liao Q, Zhu C, Sun X et al. Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance Journal of Biological Chemistry 2023-08-01 [PMID: 37481210] (In Vivo, B/N)	In Vivo, B/N
Zhang, T;Xu, D;Liu, J;Wang, M;Duan, LJ;Liu, M;Meng, H;Zhuang, Y;Wang, H;Wang, Y;Lv, M;Zhang, Z;Hu, J;Shi, L;Guo, R;Xie, X;Liu, H;Erickson, E;Wang, Y;Yu, W;Dang, F;Guan, D;Jiang, C;Dai, X;Inuzuka, H;Yan, P;Wang, J;Babuta, M;Lian, G;Tu, Z;Miao, J;Szabo, G;Fong, GH;Karnoub, AE;Lee, YR;Pan, L;Kaelin, WG;Yuan, J;Wei, W; Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation Nature cell biology 2023-07-03 [PMID: 37400498]
Kubaichuk K, Kietzmann T USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1? but Not HIF-2? Protein Synthesis Cells 2023-06-08 [PMID: 37371055] (WB, Human, Mouse)	WB	Human, Mouse
Yue Y, Tang Y, Huang H et al. VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1? but not HIF-2? The Journal of biological chemistry 2023-05-16 [PMID: 37201586] (WB, Zebrafish)	WB	Zebrafish
Aboouf MA, Armbruster J, Guscetti F et al. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice Scientific reports 2023-05-09 [PMID: 37161046] (IHC-P, Mouse)	IHC-P	Mouse
Qu M, Long Y, Wang Y et al. Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2?-Dependent Manner International Journal of Molecular Sciences 2023-04-11 [PMID: 37108194] (B/N)	B/N
Leu T, Denda J, Wrobeln A, Fandrey J Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog Molecular and cellular biology 2023-04-19 [PMID: 37074220]
Li KQ, Liu GJ, Liu XY et al. EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50 Zoological Research 2023-05-18 [PMID: 37070589] (WB, ICC/IF)	WB, ICC/IF
Sun H, Pratt RE, Dzau VJ, Hodgkinson CP Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity The Journal of biological chemistry 2023-04-10 [PMID: 37044217] (WB, ICC/IF, Mouse)	WB, ICC/IF	Mouse
Mayro B, Hoj JP, Cerda-Smith CG et al. ABL kinases regulate the stabilization of HIF-1? and MYC through CPSF1 Proceedings of the National Academy of Sciences of the United States of America 2023-04-18 [PMID: 37040401]
Ye J, Chen J, Li Y et al. Hepatocyte-specific knockout of HIF-2? cannot alleviate carbon tetrachloride-induced liver fibrosis in mice PeerJ 2023-04-03 [PMID: 37033734] (IHC-P, Mouse)	IHC-P	Mouse
Deval G, Nedder M, Degrelle S et al. Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling International journal of molecular sciences 2023-03-12 [PMID: 36982514] (IHC-P, Human) Details: Dilution: 1:500	IHC-P	Human
Sabharwal S, Dudley VJ, Landwerlin C, Schumacker P H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo The Journal of biological chemistry 2023-03-17 [PMID: 36935009] (WB, Human)	WB	Human
Sangam S, Sun X, Schwantes-An TH et al. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics American journal of respiratory and critical care medicine 2023-03-13 [PMID: 36913491]
Colson A, Depoix CL, Lambert I et al. Specific HIF-2? (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP) Hypertension (Dallas, Tex. : 1979) 2023-05-01 [PMID: 36876500] (WB, Human)	WB	Human
Jung J, Sosnowska D, Weaver J et al. Expression of Hypoxia-Inducible Factors in Different Stages of Pancreatic Tumor Progression Reports 2020-10-15 (IF/IHC, Human)	IF/IHC	Human
Robrahn L, Dupont A, Jumpertz S, et al. Conditional deletion of HIF-1 alpha provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium bioRxiv 2021-01-17 (WB, Mouse)	WB	Mouse
Zuo Q, Yang Y, Lyu Y et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis Cell reports 2023-02-28 [PMID: 36857181] (WB, Mouse)	WB	Mouse
Hashimoto Y, Tsuzuki-Nakao T, Kida N et al. Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells Biomedicines 2023-01-14 [PMID: 36672719] (WB, B/N)	WB, B/N
Kong Y, Liu PK, Li Y et al. HIF2? activation and mitochondrial deficit due to iron chelation cause retinal atrophy EMBO molecular medicine 2023-02-08 [PMID: 36645044] (WB)	WB
DAtilo MN, Formigari GP, de Faria JBL, de Faria JML AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study Experimental eye research 2022-12-09 [PMID: 36509164] (ICC/IF, Human)	ICC/IF	Human
Marinaccio C Myeloproliferative Neoplasms: From Biology to Targeted Therapeutics Thesis 2021-01-01
Kostyunina DS, Rowan SC, Pakhomov NV et al. Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells American journal of respiratory cell and molecular biology 2023-02-02 [PMID: 36730645] (WB)	WB
Quan Y, Dai J, Zhou S et al. HIF2?-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma FEBS open bio 2023-02-02 [PMID: 36728187] (ChIP, WB, Human)	ChIP, WB	Human
Chen Z, Bordieanu B, Kesavan R et al. Lactate metabolism is essential in early-onset mitochondrial myopathy Science Advances 2023-01-06 [PMID: 36598990] (In Vivo)	In Vivo
Al-Gharaibeh N, Shively S, Vortmeyer A Characterization of Microscopic Multicellular Foci in Grossly Normal Renal Parenchyma of Von Hippel-Lindau Kidney Medicina 2022-11-24 [PMID: 36556926] (IHC-P, Human) Details: Dilution used 1:50	IHC-P	Human
Yang Y, Chen C, Zuo Q Et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification Sci Adv 2022-12-09 [PMID: 36490339] (WB, Chemotaxis, Human) Details: Citation using the DyLight 405 version of this antibody.	WB, Chemotaxis	Human
Li G, Liu J, Guo M et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2 alpha -mediated alpha-synuclein hyperphosphorylation Research Square 2022-03-25 [PMID: 36450714] (WB, Mouse)	WB	Mouse
Zhang S, Cao M, Hou Z et al. Angiotensin-converting Enzyme Inhibitors Have Adverse Effects in Anti-angiogenesis Therapy for Hepatocellular Carcinoma Research Square Sep 10 2020 (WB, Mouse)	WB	Mouse
Ji X, Li G, Liu J et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2a-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation Research Square 2022-11-01 [PMID: 36450714] (WB, Mouse)	WB	Mouse
Nahoui-Zarouri I, L�ger C, El Samra G et al. Time-dependent effects of hypoxia on cell metabolism, signaling, and iron homeostasis in the hematopoietic progenitor model KG1a FEBS Open Bio 2023-07-01 [PMID: 36416440] (Func)	Func
Chen Y, Cattoglio C, Dailey GM et al. Mechanisms governing target search and binding dynamics of hypoxia-inducible factors eLife 2022-11-02 [PMID: 36322456] (Chip Cytometry, Human)	Chip Cytometry	Human
Aboouf MA, Armbruster J, Thiersch M et al. Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells International Journal of Molecular Sciences 2022-09-29 [PMID: 36232784] (ICC/IF)	ICC/IF
Sallais J, Park C, Alahari S et al. HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein-2 JCI insight 2022-10-13 [PMID: 36227697]
Ross BX, Jia L, Kong D et al. Hypoxia-Inducible Factor-1a in Rods Is Neuroprotective Following Retinal Detachment Investigative ophthalmology & visual science 2022-10-03 [PMID: 36223101] (WB, Mouse)	WB	Mouse
Ma Q, Beal JR, Song X et al. Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy Endocrinology 2022-10-11 [PMID: 36219207] (WB)	WB
Dowdell AS, Cartwright IM, Kitzenberg DA et al. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination Cell Reports 2022-09-27 [PMID: 36170839] (In Vivo)	In Vivo
Tiwari R, Bommi PV, Gao P et al. Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming iScience 2022-10-21 [PMID: 36157579] (Func)	Func
Melanson G, Du Bois AC, Webster C, Uniacke J ISGylation directly modifies hypoxia-inducible factor-2 alpha and enhances its polysome association FEBS letters 2022-08-24 [PMID: 36053046]
Ye C, Li H, Li Y et al. Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE iScience 2022-09-16 [PMID: 36034219] (KD, WB, Human)	KD, WB	Human
Zhang B, Chen Y, Bao L, Luo W GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth Cells 2022-08-20 [PMID: 36010673] (KO, WB, Human)	KO, WB	Human
Yan M, Komatsu N, Muro R et al. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts Nature immunology 2022-08-23 [PMID: 35999392] (IHC-Fr, Mouse, Human)	IHC-Fr	Mouse, Human
Henning Y, Blind US, Larafa S et al. Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction Cell death & disease 2022-07-29 [PMID: 35906211] (WB, Human)	WB	Human
Ji L, Su S, Xin M et al. Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2 alpha-Arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway Phytomedicine : international journal of phytotherapy and phytopharmacology 2022-07-08 [PMID: 35843187] (IHC-P, Rat)	IHC-P	Rat
Tapio J, Halmetoja R, Dimova E et al. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism Journal of Biological Chemistry 2022-07-01 [PMID: 35787374] (WB, Mouse)	WB	Mouse
Li S, Li W, Yuan J et al. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome Nature metabolism 2022-06-01 [PMID: 35760869] (WB, Human)	WB	Human
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J. Harrison, Grant D. Stewart, Mitchell J. Machiela, Mark P. Purdue, Stephen J. Chanock, Anne Y. Warren, Shamith A. Samarajiwa, Jason S. Carroll, Sakari Vanharanta The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer Nature 2022-06-08 [PMID: 35676472]
Han JS, Jeon YG, Oh M et al. Adipocyte HIF2 alpha functions as a thermostat via PKA C alpha regulation in beige adipocytes Nature communications 2022-06-07 [PMID: 35672324] (IF/IHC, Mouse)	IF/IHC	Mouse
Jacquier V, Gitenay D, Fritsch S et al. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53 Cellular and molecular life sciences : CMLS 2022-05-03 [PMID: 35501580] Details: Fig. 1
Salman S, Meyers DJ, Wicks EE Et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy J Clin Invest 2022-05-02 [PMID: 35499076] (Chemotaxis, WB, Mouse, Human) Details: Citation using the Alexa Fluor 488 version of this antibody.	Chemotaxis, WB	Mouse, Human
Jae-Su Moon, Matthew Riopel, Jong Bae Seo, Vicente Herrero-Aguayo, Roi Isaac, Yun Sok Lee HIF-2 alpha Preserves Mitochondrial Activity and Glucose Sensing in Compensating beta -Cells in Obesity. Diabetes 2022-06-28 [PMID: 35472707]
Xia QS, Wu F, Wu WB et al. Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2 alpha Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022-04-13 [PMID: 35429745] (WB, ICC/IF, IHC-P, Human, Mouse)	WB, ICC/IF, IHC-P	Human, Mouse
Moyama C, Fujita M, Ando S et al. Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model American journal of cancer research 2022-03-15 [PMID: 35411230] (WB)	WB
Wolf C, Smith S, van Wijk SJL Zafirlukast Induces VHL- and HIF-2alpha-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells International journal of molecular sciences 2022-03-25 [PMID: 35408930] (WB)	WB
Matho C VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF- Independent Actions Front. Endocrinol. 13: 854365. doi: 10.3389/fendo 2022-01-01 [PMID: 35388293] (WB, Human)	WB	Human
Nelson LJ, Castro KE, Xu B et al. Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma Cell cycle (Georgetown, Tex.) 2022-03-04 [PMID: 35240916] (WB, Human)	WB	Human
Armstrong N, Storey CM, Noll SE et al. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas Cell reports 2022-03-01 [PMID: 35235785] (Mouse)		Mouse
Qin y, Zhang J, Babapoor-Farrokhran S et al. PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients Science advances 2022-03-04 [PMID: 35235351] (IHC-Fr, Human)	IHC-Fr	Human
Zhao L, Han Q, Zhou L et al. Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes Renal failure 2022-12-01 [PMID: 35188068] (IF/IHC, Human)	IF/IHC	Human
Wang X, Hu J, Fang Y et al. Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines Cells 2022-01-29 [PMID: 35159281] (WB, Human)	WB	Human
Medeiros PJ, Pascetta SA, Kirsh SM et al. Expression of hypoxia inducible factor-dependent Neuropeptide Y Receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation The Journal of biological chemistry 2022-01-27 [PMID: 35093384] (WB, Human)	WB	Human
Mennerich D, Kubaichuk K, Raza GS et al. ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/ beta TrCP Redox biology 2022-01-18 [PMID: 35074541] (WB, Human, Mouse)	WB	Human, Mouse
Yang Y, Lu H, Chen C et al. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia Nature communications 2022-01-14 [PMID: 35031618] (Chemotaxis, WB)	Chemotaxis, WB
Sabui S, Ramamoorthy K, Romero J et al. Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1 alpha-mediated transcriptional regulation of their transporters Journal of Biological Chemistry 2022-01-01 [PMID: 34998824]
Elamaa H, Kaakinen M, NAtynki M et al. PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis Angiogenesis 2022-01-08 [PMID: 34997404] (WB, Mouse)	WB	Mouse
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Yang Q, Guo X, Yang L. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2a (HIF-2a) and 30 kDa HIV Tat-Interacting Protein (TIP30). Med. Sci. Monit. 2018-04-14 [PMID: 29654226] (WB)	WB
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Gastelum Gilberto, Poteshkina Aleksandra, Veena Mysore et al. RestoRation of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2a expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PloS One 2017-01-01 [PMID: 29206844] (WB, Mouse)	WB	Mouse
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Tsang KM, Hyun JS, Cheng KT et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1alpha Stem Cell Reports 2017-07-24 [PMID: 28781077] (WB, Mouse)	WB	Mouse
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Lim E, Kuo CC, Tu HF, Yang CC. The prognosis outcome of oral squamous cell carcinoma using HIF-2alpha J Chin Med Assoc 2017-07-06 [PMID: 28690120] (IHC-P, Human)	IHC-P	Human
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Gardner PJ, Liyanage SE, Cristante E et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye Sci Rep 2017-01-23 [PMID: 28112274] (WB, Mouse)	WB	Mouse
Yamamura K, Uruno T, Shiraishi A et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction Nat Commun 2017-01-09 [PMID: 28067314] (ICC/IF, Mouse)	ICC/IF	Mouse
Kozlova N, Wottawa M, Katschinski DM et al. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 2017-02-07 [PMID: 28038470]
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Chen T, Zhou Q, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc 2016-12-05 [PMID: 27919930] (WB, Mouse)	WB	Mouse
Nakayama T, Otsuka S, Kobayashi T et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep. 2016-11-18 [PMID: 27857072] (WB, Human)	WB	Human
Thompson JM, Nguyen QH, Singh M et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2016-11-14 [PMID: 27841867]
Zhang L, Du J, Justus S et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J. Clin. Invest. 2016-12-01 [PMID: 27841758] (WB, Mouse)	WB	Mouse
Isono T, Chano T, Yoshida T et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res. 2016-11-08 [PMID: 27822416] (Human)		Human
Ke S, Chen S, Dong Z et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2016-10-24 [PMID: 27774607]
Ha JH, Doguer C, Collins JF. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016-08-22 [PMID: 27714044]
D'Alessio A, Proietti G, Lama G et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget. 2016-11-29 [PMID: 27705944] (IF/IHC, Human)	IF/IHC	Human
Pangou E, Befani C, Mylonis I et al. HIF-2alpha phosphorylation by CK1delta promotes erythropoietin secretion in liver cancer cells under hypoxia. J. Cell. Sci. 2016-11-15 [PMID: 27686097]
Dehn S, DeBerge M, Yeap X et al. HIF-2a in Resting Macrophages Tempers Mitochondrial ROS to Selectively Repress MARCO-dependent Phagocytosis. J Immunol. 2016-11-01 [PMID: 27671111] (WB, Mouse)	WB	Mouse
Wang S, Zeng H, Xie XJ et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget. 2016-09-13 [PMID: 27613846] (WB, Mouse)	WB	Mouse
Gortz Ge, Horstmann M, Aniol B et al. Hypoxia-dependent HIF-1 activation impacts on tissue remodeling in Graves' ophthalmopathy - implications for smoking. J. Clin. Endocrinol. Metab. 2016-09-09 [PMID: 27610652]
Frey H, Moreth K, Hsieh LT et al. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia Glycoconjugate Journal 2017-06-01 [PMID: 27600268] (ELISA, WB)	ELISA, WB
Zhang C, Zhi WI, Lu H et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016-08-31 [PMID: 27590511] (WB, Human)	WB	Human
Prakash H, Nadella V, Singh S, Schmitz-Winnenthal H. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep. 2016-08-11 [PMID: 27511884]
Gstalder C, Ader I, Cuvillier O. FTY720 (Fingolimod) inhibits HIF-1 and HIF-2 signaling, promotes vascular remodeling and chemosensitizes in renal cell carcinoma animal model. Mol. Cancer Ther. 2016-08-09 [PMID: 27507852] (WB)	WB
Nauta TD, Duyndam MC, Weijers EM et al. HIF-2alpha Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE. 2016-08-05 [PMID: 27490118] (WB, Human)	WB	Human
Depner C, Zum Buttel H, Bourcu N et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun. 2016-07-29 [PMID: 27470974] (WB)	WB
Leinonen H, Rossi M, Salo AM et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016-07-27 [PMID: 27466183] (WB, Mouse)	WB	Mouse
Cui J, Duan B, Zhao X et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol 2016-10-01 [PMID: 27465550] (Human)		Human
Pramono A, Zahabi A, Morishima T et al. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1a-dependent activation of a BMP4 autoregulatory loop Ann. N. Y. Acad. Sci. 2016-07-01 [PMID: 27447537] (WB, Mouse)	WB	Mouse
Chen H, Hong F, Chen Y et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion Eur. J. Pharmacol. 2016-07-13 [PMID: 27423314]
Luo B, Wang J, Liu Z et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun. [PMID: 27397585] (WB) Details: Citation using the HRP form of this antibody.	WB
Nunomiya A, Shin J, Kitajima Y et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 2016-07-09 [PMID: 27393382]
Lee MC, Huang HJ, Chang TH et al. Genome-wide analysis of HIF-2alpha chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep 2016-07-04 [PMID: 27373565] (WB)	WB
Mandl M, Lieberum MK, Depping R. A HIF-1alpha-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis 2016-06-30 [PMID: 27362802] (WB)	WB
Diaz-Trelles R, Scimia MC, Bushway P et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 2016-06-30 [PMID: 27357444] (WB)	WB
Kowitzke B, Cohrs G, Leuschner I et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J Neuropathol Exp Neurol 2016-09-01 [PMID: 27354486] (Human)		Human
Mao XG, Wang C, Liu DY et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma Oncotarget 2016-07-26 [PMID: 27329597] (Chemotaxis, Human)	Chemotaxis	Human
Higashimura Y, Kitakaze T, Harada N et al. pVHL-mediated degradation of HIF-2a regulates estrogen receptor a expression in normoxic breast cancer cells. FEBS Lett. 2016-06-21 [PMID: 27323688] (WB, Human)	WB	Human
Zhang X, Prasadam I, Fang W et al. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2 alpha activity. Osteoarthr. Cartil. 2016-06-16 [PMID: 27321194] (IF/IHC)	IF/IHC
Maugeri G, Grazia D'Amico A, Reitano R et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016-05-31 [PMID: 27303300] (WB)	WB
Mahara S, Lee PL, Feng M et al. HIFI-a activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc. Natl. Acad. Sci. U.S.A. 2016-06-28 [PMID: 27303043] (WB, Human)	WB	Human
Hoefflin R, Lahrmann B, Warsow G et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016-06-13 [PMID: 27291893] (IF/IHC)	IF/IHC
Hoang NT, Kadonosono T, Kuchimaru T, Kizaka-Kondoh S Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci 2016-08-01 [PMID: 27270607] (WB)	WB
Mammadzada P, Gudmundsson J, Kvanta A, Andre H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis Acta Ophthalmol. [PMID: 27255568] (WB, Human)	WB	Human
Rodriguez S, Rudloff S, Koenig KF et al. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016-05-26 [PMID: 27228995] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Warfel NA, Sainz AG, Song JH, Kraft AS. PIM kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species. Mol. Cancer Ther. 2016-05-16 [PMID: 27196781] (WB, Human)	WB	Human
Christinat Y, Pawlowski R, Krek W. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics 2016-07-15 [PMID: 27153587]
Dai Z, Li M, Wharton J et al. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2a. Circulation 2016-06-14 [PMID: 27143681] (WB, Mouse)	WB	Mouse
Fitzpatrick SF, Fabian Z, Schaible B et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kB-dependent manner. Biochem. Biophys. Res. Commun. 2016-04-26 [PMID: 27130823] (WB, Human)	WB	Human
Selfridge AC, Cavadas MA, Scholz CC et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J. Biol. Chem. 2016-05-27 [PMID: 27044749] (WB, Mouse, Human)	WB	Mouse, Human
Timpano S, Uniacke J. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J Biol Chem 2016-05-13 [PMID: 27002144]
Zhang C, Samanta D, Lu H et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016-03-21 [PMID: 27001847] (WB, Human)	WB	Human
Nam H, Jones D, Cooksey RC et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes 2016-06-01 [PMID: 26993063] (WB, Human)	WB	Human
German P, Bai S, Liu XD et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene 2016-09-22 [PMID: 26973240]
You A, Cao M, Guo Z et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol 2016-03-08 [PMID: 26957312] (WB)	WB
Zeng H, He X, Tuo QH et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2alpha/Notch3 pathways. Sci Rep. 2016-02-12 [PMID: 26868537] (WB, Mouse, Human)	WB	Mouse, Human
Mori H, Yao Y, Learman BS et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1alpha regulates cell proliferation, migration and invasion. Sci Rep. 2016-02-10 [PMID: 26861754] (WB, Human)	WB	Human
Heir P, Srikumar T, Bikopoulos G et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem 2016-04-01 [PMID: 26846855]
Nakazawa MS, Eisinger-Mathason TS, Sadri N et al. Epigenetic re-expression of HIF-2alpha suppresses soft tissue sarcoma growth. Nat Commun 2016-02-03 [PMID: 26837714] (WB)	WB
Luo W, Chen I, Chen Y et al. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia Oncotarget. 2016-02-09 [PMID: 26837221] (WB) Details: The mechanism for feedback inhibition of hypoxia-inducible factors during prolonged hypoxia is clarified through studying the interaction of PRDX2 and PRDX4 with HIF-1 alpha and HIF-2 alpha.	WB
Regan Anderson TM, Ma SH, Raj GV et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer Cancer Res. 2016-01-29 [PMID: 26825173] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Kadam PD, Chuan HH. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016-03-01 [PMID: 26811110] Details: This citation used the HRP version of this antibody.
Qian F, He M, Duan W et al. Cross regulation between hypoxia-inducible transcription factor-1alpha (HIF-1alpha) and transforming growth factor (TGF)-ss1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res 2015-01-01 [PMID: 26807184] (WB)	WB
Mysore VS, Szablowski J, Dervan PB, Frost PJ. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. [PMID: 26801054] (WB, Human)	WB	Human
Kim Y, Nam HJ, Lee J et al. Methylation-dependent regulation of HIF-1alpha stability restricts retinal and tumour angiogenesis. Nat Commun 2016-01-13 [PMID: 26757928]
Chen K, Zeng J, Xiao H et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1alpha. J. Cell. Sci. 2016-01-07 [PMID: 26743088] (WB, Human) Details: HIF-2 alpha/EPAS1 was used at 1:500 dilution for WB assays in experiments involving human kidney cell lines namely ACHN, Caki-1 and HEK293T.	WB	Human
Bino L, Kucera J, Stefkova K et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem Biol Interact 2016-01-25 [PMID: 26723917]
Messai Y, Gad S, Noman MZ et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur. Urol. 2015-12-17 [PMID: 26707870] (WB, Human)	WB	Human
Laukka T, Mariani CJ, Ihantola T et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem 2016-02-19 [PMID: 26703470]
Cavadas MA, Mesnieres M, Crifo B et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep. 2015-12-09 [PMID: 26647819] (WB, Human)	WB	Human
Vukovic M, Guitart AV, Sepulveda C et al. Hif-1alpha and Hif-2alpha synergize to suppress AML development but are dispensable for disease maintenance. J. Exp. Med. 2015-12-14 [PMID: 26642852] (WB, Human)	WB	Human
Bhanu NV, Sidoli S, Garcia BA. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics. 2016-02-01 [PMID: 26631989]
Sun W, Kosyna FK, Jelkmann W, Depping R. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4alpha Expression. Cell. Physiol. Biochem. 2015-12-24 [PMID: 26624507] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015-11-17 [PMID: 26572229] (WB, Human)	WB	Human
Cheng S, Xing W, Pourteymoor S et al. Conditional Deletion of Prolyl Hydroxylase Domain-containing Protein 2 (Phd2) Gene Reveals its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. 2015-11-12 [PMID: 26562260] (WB, Mouse)	WB	Mouse
Aquino-Galvez A, Gonzalez-avila G. Effects of 2-methoxyestradiol on apoptosis and HIF-1a and HIF-2a expression in lung cancer cells under normoxia and hypoxia. ONCOLOGY REPORTS. 2015-08-20 [PMID: 26548300] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Highet AR, Khoda SM, Buckberry S et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur. J. Cell Biol. 2015-12-01 [PMID: 26531845] (IHC-P, Human) Details: HIF2 alpha antibody was used for IHC-P on early / late first trimester and term uncomplicated control placentas. The IHC assay involved antigen retrieval through boiling the slides with citrate buffer pH 6.5 in microwave, blocking of endogenous peroxidase using 6% H2O2 for 1 hour, use of primary at 1:1500 dilution, and detection using biotinylated secondary, Streptavidin-HRP conjugate-DAB followed by counterstaining with haematoxylin (Fig. 5).	IHC-P	Human
Huh Yun Hyun, Lee Gyuseok, Lee Keun-Bae et al. HIF-2a-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Research & Therapy 2015-01-01 [PMID: 26510617] (IF/IHC, Mouse)	IF/IHC	Mouse
Zhang J, Wang C, Chen X et al. EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer. EMBO J 2015-12-02 [PMID: 26492917] (WB, Human)	WB	Human
Kuei-Yang Hsiao, Meng-Hsing Wu, Ning Chang, Shang-Hsun Yang, Chun-Wei Wu, H Sunny Sun, Shaw-Jenq Tsai Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Molecular human reproduction 2016-09-20 [PMID: 26433194]
Saini Y, Proper SP, Dornbos P et al. Loss of Hif-2alpha Rescues the Hif-1alpha Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS One 2015-01-01 [PMID: 26422241] (IF/IHC, Mouse)	IF/IHC	Mouse
Stengel C, Newman SP, Leese MP et al. The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression Anticancer Res. 2016-03-31 [PMID: 26408684] (WB, Human)	WB	Human
Frey JL, Stonko DP, Faugere MC, Riddle RC Hypoxia-inducible factor-1alpha restricts the anabolic actions of parathyroid hormone. Bone Res 2014-05-13 [PMID: 26273518] (IP)	IP
Lu H Samanta D Xiang L et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015-07-30 [PMID: 26229077] (WB, Human)	WB	Human
Hogel H, Miikkulainen P, Bino L, Jaakkola PM. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer. 2015-07-30 [PMID: 26223520] (WB, Human) Details: PHD1 antibody used for WB on 786-O cell under hypoxia (1% O2) and normoxia (21 % O2) by siPHD1 (Figure 1C).	WB	Human
Ramakrishnan SK, Anderson ER, Martin A et al. Maternal intestinal HIF-2a is necessary for sensing iron demands of lactation in mice Proc. Natl. Acad. Sci. U.S.A. 2015-07-14 [PMID: 26124130] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Zhang X, Zhu J, Liu F et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2014-08-05 [PMID: 26120493] (IF/IHC)	IF/IHC
Otto T, Gellhaus A, Luschen N et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia? J Cell Biochem 2015-05-27 [PMID: 26018820]
Matsuyama T, Tanaka T, Tatsumi K et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur. J. Pharmacol. 2015-05-19 [PMID: 26001375] (WB, Mouse)	WB	Mouse
Lin AE, Beasley FC, Olson J et al. Role of Hypoxia Inducible Factor-1alpha (HIF-1alpha) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015-04-01 [PMID: 25927232] (WB, Human)	WB	Human
Forristal CE, Brown AL, Helwani FM et al. Hypoxia inducible factor (HIF)-2alpha accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia. 2015-04-29 [PMID: 25921247] (WB, Mouse)	WB	Mouse
Koizume S, Ito S, Nakamura Y et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer Mol. Cancer 2015-04-17 [PMID: 25879517] (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human
Shao J, Zhang Y, Yang T et al. HIF-1alpha disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression In Vitro Cell. Dev. Biol. Anim. 2015-04-10 [PMID: 25859979] (WB, Mouse)	WB	Mouse
Rad E, Dodd K, Thomas L et al. STAT3 and HIF1alpha Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol Cancer Res 2015-07-01 [PMID: 25833823] (Human)		Human
Wu S, Zhang J, Huang C et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther 2015-01-01 [PMID: 25832622] (Mouse)		Mouse
McMurray F, Demetriades M, Aik W et al. Pharmacological Inhibition of FTO. PLoS One. 2015-04-01 [PMID: 25830347] (WB, Mouse)	WB	Mouse
Qiu B, Ackerman D, Sanchez DJ et al. HIF-2alpha dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma Cancer Discov 2015-03-31 [PMID: 25829424] (WB, Human)	WB	Human
Shaw D, Wang X, Brown L et al. Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nature Communications. [PMID: 25790189]
Zeng H, Vaka VR, He X et al. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J. Cell. Mol. Med. 2015-03-17 [PMID: 25782072] (WB, Mouse)	WB	Mouse
Cotroneo E, Ashek A, Wang L et al. Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat. Circ. Res. 2015-03-12 [PMID: 25767292] (WB, Rat)	WB	Rat
Doonachar A, Gallo MD, Doukas D et al. Differential effects of HIF-alpha isoforms on apoptosis in renal carcinoma cell lines Cancer Cell Int. 2015-03-02 [PMID: 25729330] (WB, Human)	WB	Human
Jimenez K, Khare V, Evstatiev R et al. Increased expression of HIF2alpha during iron deficiency-associated megakaryocytic differentiation J. Thromb. Haemost. 2015-02-25 [PMID: 25715026] (IHC-P, Rat)	IHC-P	Rat
Matak P, Heinis M, Mathieu JR et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis J. Immunol. 2015-02-20 [PMID: 25710915] (IHC-P, Human)	IHC-P	Human
Chen Rui, Xu Min, Nagati Jason S et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS One. 2014-01-01 [PMID: 25689462]
Nozawa-Suzuki N, Nagasawa H, Ohnishi K, Morishige KI. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer Biochem. Biophys. Res. Commun. 2015-01-22 [PMID: 25619133] (WB, Human)	WB	Human
Neelam S, Brooks MM, Cammarata PR. Lenticular cytoprotection, part 2: Link between glycogen synthase kinase-3b, epithelial to mesenchymal transition, and mitochondrial depolarization. Molecular Vision. 2014-01-01 [PMID: 25593505] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB on lysates of HLE-B3 cells, a human lens epithelial cell line immortalized by the SV-40 virus, treated or not with HIF-2 alpha translation inhibitor (CAS882268-69-1) at 0.5, 5 and 50 uM concentrations (Figure 11A)	WB	Human
Xiang L, Gilkes DM, Hu H et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014-01-01 [PMID: 25587023] (WB, IP, Chemotaxis, Human)	WB, IP, Chemotaxis	Human
Gong H, Rehman J, Tang H et al. HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest 2015-02-01 [PMID: 25574837]
Yoo S, Takikawa S, Geraghty P et al. Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD PLoS Genet. 2015-01-01 [PMID: 25569234] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for IHC-P on human lung tissues from Chronic Obstructive Pulmonary Disease/COPD and non-COPD patients - antigen retrieval with 10 mM citrate buffer, endogenous peroxidase blocked with 0.3% H2O2-methanol , blocked with 5% goat serum diluted in PBS containing 0.1% Tween-20 for 30 minutes, primary antibody used at 1:100 dilution with 1 hour RT incubation, detection with anti-rabbit-HRP secondary and Vectastain ABC Elite Kit. HIF-2 alpha/EPAS1 protein levels were found to be lower in the lung tissues of COPD patients compared to control subjects.	WB	Human
Tsuboi I, Yamashita T, Nagano M et al. Impaired expression of HIF -2alpha induces compensatory expression of HIF-1alpha for the recovery from anemia J. Cell. Physiol. 2015-01-03 [PMID: 25557133] (WB, Chemotaxis, Mouse)	WB, Chemotaxis	Mouse
Cannito S, Turato C, Paternostro C et al. Hypoxia up-regulates SERPINB3 through HIF-2alpha in human liver cancer cells. Oncotarget. 2015-02-10 [PMID: 25544768] (Chemotaxis, Human)	Chemotaxis	Human
D C Singleton, P Rouhi, C E Zois et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene 2014-12-08 [PMID: 25486436] (WB, Human)	WB	Human
Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014-12-01 [PMID: 25453096] (WB, Human)	WB	Human
Koh MY, Nguyen V, Lemos R et al. Hypoxia-Induced SUMOylation of E3 Ligase HAF Determines Specific Activation of HIF2 in Clear-Cell Renal Cell Carcinoma. Cancer Res. 2014-11-24 [PMID: 25421578] (WB, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB, ChIP, ICC-IF and IHC-P in experiments involving A498, 786-O, PANC-1, MIAPaCa-2, and ACHN cell lines and tumor microarray /TMAs comprising pretreatment nephrectomy specimens of patients with metastatic grade 3/4 CRCC treated with sorafenib or sorafenib plus interferon.	WB	Human
Henze At, Garvalov Bk, Seidel S et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun. 2014-11-25 [PMID: 25420773]
Hou P, Kuo Cy, Cheng Ct et al. Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1Alpha by Inhibiting Prolyl-4-Hydroxylase PHD2. PLoS OnE. 2014-11-25 [PMID: 25420025] (WB, Human)	WB	Human
Qi Y, Liu J, Saadat S et al. PTEn induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2014-11-14 [PMID: 25394489] (WB, Mouse)	WB	Mouse
Chen Sj, Hoffman Ne, Shanmughapriya S et al. A Splice Variant of the Human Ion Channel TRPM2 Modulates neuroblastoma Tumor Growth Through HIF-1/2Alpha. J. Biol. Chem. 2014-11-12 [PMID: 25391657] (WB, Human)	WB	Human
MEsange P, Poindessous V, Sabbah M et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor Oncotarget. 2014-01-19 [PMID: 25015210] (IF/IHC, WB, Mouse)	IF/IHC, WB	Mouse
Gkotinakou I, Kechagia E, Pazaitou Panayiotou K et al. Regulation of Hypoxia Inducible Factors HIF-1 and HIF-2 by Calcidiol in Hepatocellular Carcinoma Cells Under Normoxia and Hypoxia SSRN Electronic Journal 2022-08-20 (WB, Human) Details: Dilution used for WB 1:800	WB	Human
Hu H, Takano N, Xiang L et al. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget 2014-10-15 [PMID: 25326682] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Nagaya Y, Aoyama M, Tamura T et al. Inflammatory cytokine tumor necrosis factor Alpha suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2Alpha. Eur. J. neurosci. 2014-10-04 [PMID: 25283246] (WB)	WB
Petruzzelli R, Christensen DR, Parry KL et al. HIF-2a Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element. PLoS ONE. 2014-10-02 [PMID: 25271810] (ICC/IF, Chemotaxis, Human) Details: HIF-2 alpha/EPAS1 antibody used for ChIP and ICC-IF in experiments involving human embryonic stem cell /hESC.	ICC/IF, Chemotaxis	Human
Lalevee S, Lapaire O, Buhler M. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis. 2014-09-04 [PMID: 25188518]
Fujikuni N, Yamamoto H, Tanabe K et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci 2014-11-01 [PMID: 25174257] (WB)	WB
Asnaghi L, Lin MH, Lim KS et al. Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation. PLoS ONE. 2014-08-28 [PMID: 25166211] (WB, Human)	WB	Human
Li B, Qiu B, Lee DS et al. Fructose-1, 6-bisphosphatase opposes renal carcinoma progression. Nature 2014-09-11 [PMID: 25043030] (IP, WB, Human)	IP, WB	Human
Wong WJ, Richardson T, Seykora JT et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol 2015-02-01 [PMID: 24999590] (WB)	WB
Liu XD, Yao J, Tripathi DN et al. Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis. Oncogene 2014-07-07 [PMID: 24998849] (WB, CoIP, IP, Human) Details: HIF-2 alpha antibody used for WB, IP and CoIP in several experiments involving Caki-I cells, RPE cells, HEK293T stable cell line expressing HIF2a-GFP, 786-O parental cells/ and its over-expression derivatives, and Atg5+/+ or Atg5- / - MEFs stably expressing HIF2a-GFP.	WB, CoIP, IP	Human
Magliulo D, Caserta C, Belluschi S et al. The transcription factor HIF2alpha partakes in the differentiation block of acute myeloid leukemia Research Square 2022-06-15 (Chemotaxis, Human)	Chemotaxis	Human
Muz B, de la Puente P, Azab F et al. Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenstrom's Macroglobulinemia. Mol. Cancer Res. 2014-09-17 [PMID: 25232031] (WB, Mouse)	WB	Mouse
Yoshizawa Sayuri, Brown Andrew, Barchowsky Aaron, Sfeir Charles. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect Tissue Res. 2014-08-01 [PMID: 25158202]
Hubbi ME, Gilkes DM, Hu H et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1alpha to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014-07-28 [PMID: 25071185] (WB, Human)	WB	Human
Zhao B, Li K, Liu G et al. EPAS1 protects fibroblasts from replicative senescence through telomeric stability Research Square Apr 6 2022 (ICC/IF, Bat)	ICC/IF	Bat
Melanson G Computational analysis implicates interferon-stimulated gene 15 in hypoxic ribonucleoprotein dynamics Thesis 2021-01-01 (WB, Human)	WB	Human
Assar Me, Sanchez-Puelles Jm, Royo I et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/enOS pathway, independently of mTOR/HIF-1Alpha activation Br. J. Pharmacol. 2014-11-03 [PMID: 25363469] (WB, Rat) Details: HIF-1 alpha antibody used for WB on lysates of ex vivo FM19G11 treated aortic and mesenteric arteries from control and insulin-resistant rats (Figure 6).	WB	Rat
Su Ej, Xin H, Yin P et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery Doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARnT). J. Clin. Endocrinol. Metab. 2014-10-24 [PMID: 25343232] (WB, Human)	WB	Human
Wu R, Chang Hc, Khechaduri A et al. Cardiac-specific ablation of ARnT leads to lipotoxicity and cardiomyopathy. J. Clin. Invest. 2014-11-03 [PMID: 25329697] (Chemotaxis, Human)	Chemotaxis	Human
Zhou Y, Yuge A, Rajah Am et al. LIMK1 Regulates Human Trophoblast Invasion/Differentiation and Is Down-Regulated in Preeclampsia. Am. J. Pathol. 2014-10-09 [PMID: 25307528] (IF/IHC, Human)	IF/IHC	Human
Bordji K, Grandval A, Cuhna-Alves L et al. Hypoxia-inducible factor-2a (HIF-2a), but not HIF-1a, is essential for hypoxic induction of class III b-tubulin expression in human glioblastoma cells. FEBS J. 2014-09-22 [PMID: 25244496] (WB, GS, Human) Details: HIF-2 alpha/EPAS1 antibody used for WB and EMSA/Gel Super Shift Assay in experiments involving human glioblastoma cell lines - U87MG (p53 wild-type, PTEN mutant) , U251MG (p53 mutant, PTEN mutant) and GL15 (obtained from a frontal lobe tumor biopsy of a 59-year-old man with GBM).	WB, GS	Human
Kurt B, Gerl K, Karger C et al. Chronic Hypoxia-Inducible Transcription Factor-2 Activation Stably Transforms Juxtaglomerular Renin Cells into Fibroblast-Like Cells In Vivo J Am Soc Nephrol. 2014-07-27 [PMID: 25071089] (IF/IHC, Mouse)	IF/IHC	Mouse
Slominski A, Kim TK, Brozyna AA et al. The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1a expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014-07-02 [PMID: 24997364] (WB, Hamster, Human) Details: HIF-1 alpha antibody used for WB on whole cell lysates of Bomirski hamster AbC1 and human SKMEL-188 stable lined (amelanotic /non-pigmented and melanotic /pigmented lines) with Hif1a wild type/WT and knockout /KO mammary tumor epithelial cells (MTECs) derived from the polyoma virus middle T transgenic mouse (MMTV-PyMT) as positive control for HIF-1 alpha. Antibody used at 1:5000 dilution and the data is shown in Fig 1.	WB	Hamster, Human
Kono K, Tamashiro DA, Alarcon VB. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of hippo signaling in the mouse blastocyst. Dev. Biol. 2014-07-02 [PMID: 24997360] (WB, Human, Hamster) Details: HIF-2 alpha antibody used for WB on lysates of Bomirski hamster AbC1 and human SKMEL-188 cell lines (Fig. 1).	WB	Human, Hamster
Takano N, Sarfraz Y, Gilkes DM et al. Decreased Expression of Cystathionine b-Synthase Promotes Glioma Tumorigenesis. Mol Cancer Res. 2014-07-03 [PMID: 24994751] (WB, Human)	WB	Human
Mangiavini L, Merceron C, Araldi E et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development Dev. Biol. 2014-06-24 [PMID: 24972088] (IHC-P, Mouse) Details: HIF-1 alpha antibody used for Western blot at 1:1000 dilution in protein lysate from chondrocytes of CNTRL and VHL mice ( protocol details provided in this article, WB image - Supplemental Fig. 1, Panel B)	IHC-P	Mouse
Rana S, Rajakumar A, Geahchan C et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1alpha pathway. FASEB J. 2014-06-26 [PMID: 24970393] (WB, Human) Details: Used for WB on HIF-2 expression in both normal and pre-eclamptic placental villous explant cultures treated with 500 nM ouabain(Fig. 3F, G).	WB	Human
Furcht CM, Buonato JM, Skuli N et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J. Cell. Sci. 2014-06-20 [PMID: 24951116] (WB, Human) Details: Antibody used for detecting HIF2 alpha by WB in U87MG-M 281 control or SHP2 knockdown cells generated ectopic xenograft tumors in Nu/Nu mice (Fig. 6C, 6D)	WB	Human
Salman Shaima, Holloway Alison C, Nurse Colin A. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2alpha and protein kinase A. Am J Physiol Cell Physiol. 2014-08-01 [PMID: 24898587] (Rat)		Rat
Arreola A, Cowey CL, Coloff JL et al. HIF1alpha and HIF2alpha Exert Distinct Nutrient Preferences in Renal Cells. PLoS ONE. 2014-06-02 [PMID: 24879016] (ICC/IF, Mouse)	ICC/IF	Mouse
Rawluszko-Wieczorek A A, Horbacka K et al. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol Cancer Res 2014-01-08 [PMID: 24825851] (WB, Human)	WB	Human
Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. [PMID: 24799675] (Chemotaxis, Human) Details: Citation using the FITC form of this antibody.	Chemotaxis	Human
Ding Z, German P, Bai S et al. Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein. Cancer Research 2014-03-13 [PMID: 24755468] (WB, Human)	WB	Human
Gerovac BJ, Valencia M, Baumlin N et al. Submersion and Hypoxia Inhibit Ciliated Cell Differentiation in a Notch Dependent Manner.. Am. J. Respir. Cell Mol. Biol. [PMID: 24754775]
Pang M, Liu X, Slagle-Webb B. Role of H-Ferritin in Radiosensitivity of Human Glioma Cells. HSOA Journal of Cancer Biology and Treatment 2016-01-21 [PMID: 24707546] (WB, Human)	WB	Human
Kihira Yoshitaka, Miyake Mariko, HiRata Manami et al. Deletion of hypoxia-inducible factor-1a in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PloS One 2014-01-01 [PMID: 24705496] (WB, Mouse)	WB	Mouse
Qin N, de Cubas AA, Garcia-Martin R et al. Opposing effects of HIF1a and HIF2a on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MAX. Int. J. Cancer 2014-03-27 [PMID: 24676840] (WB, IHC-P, Human, Mouse)	WB, IHC-P	Human, Mouse
Heyboer M, Milovanova TN, Wojcik S et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - Changes with oxygen dosage. Stem Cell Res 2014-03-19 [PMID: 24642336] (FLOW, Human)	FLOW	Human
Zhang J, Ma WY. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet. Mol. Res. 2014-01-24 [PMID: 24615084] (WB, Human)	WB	Human
Huang YH, Lin MH, Wang PC et al. Hypoxia inducible factor 2a/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014-03-23 [PMID: 24598112] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Lian G, Wei C, Wang D et al. Protein Profiling of H. pylori-Associated Gastric Cancer. Am. J. Pathol. 2014-02-28 [PMID: 24589339] (WB, Human)	WB	Human
Fiorito Veronica, Neri Francesco, Pala Valentina et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2alpha and ETS1. Biochim Biophys Acta. 2014-02-24 [PMID: 24576667]
Yoshizawa S, Brown A, Barchowsky A. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater 2014-02-24 [PMID: 24512978] (WB, Human)	WB	Human
Duan LJ, Takeda K, Fong GH. Hematological, Hepatic, and Retinal Phenotypes in Mice Deficient for Prolyl Hydroxylase Domain (PHD) Proteins in the Liver. Am. J. Pathol. 2014-02-19 [PMID: 24508125] (WB, Mouse)	WB	Mouse
Wojciak-Stothard B, Abdul-Salam Vb, Lao Kh et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension Circulation et al. 2014-04-29 [PMID: 24503951] (WB, Mouse) Details: HIF2 alpha antibody used for WB on lysates from lungs of wildtype (WT) and CLIC4 KO mice subjected to normoxic and hypoxic conditions.	WB	Mouse
Weisel FC, Kloepping C, Pichl A et al. Impact of S-Adenosylmethionine Decarboxylase 1 in Pulmonary Vascular Remodeling. Circulation 2014-01-28 [PMID: 24470481] (Chemotaxis, Human, Mouse)	Chemotaxis	Human, Mouse
Chen Z, Liu X, Mei Z, Xiao W. EAF2 Suppresses Hypoxia-Induced Factor 1 alpha Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300. Mol. Cell. Biol. 2014-03-01 [PMID: 24421387] (WB, Human)	WB	Human
Kumar V, Everingham S, Hall C et al. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur J Immunol 2013-12-05 [PMID: 24375267] (WB, Mouse)	WB	Mouse
Place TL, Nauseef JT, Peterson MK et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS One 2013-12-18 [PMID: 24367580] (WB, Human)	WB	Human
Gomes AP, Price NL, Ling AJ et al. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Cell 2013-12-19 [PMID: 24360282] (WB, Mouse)	WB	Mouse
Pasupuleti V, Du W, Gupta Y et al. Dysregulated D-Dopachrome Tautomerase, a Hypoxia Inducible Factor-Dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis. J Biol Chem 2013-12-19 [PMID: 24356968] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Zhu J, Jiang X, Chehab FF. FoxO4 Interacts with the Sterol Regulatory Factor SREBP2 and the Hypoxia Inducible Factor HIF2A at the CYP51 Promoter. J Lipid Res 2013-12-18 [PMID: 24353279] (Chemotaxis, WB, Mouse)	Chemotaxis, WB	Mouse
Razorenova OV, Castellini L, Colavitti R et al. The Apoptosis Repressor with a CARD Domain (ARC) Gene Is a Direct Hypoxia-Inducible Factor 1 Target Gene and Promotes Survival and Proliferation of VHL-Deficient Renal Cancer Cells. Mol Cell Biol 2014-02-01 [PMID: 24344197] (WB, Human)	WB	Human
Takano N, Peng YJ, Kumar GK et al. Hypoxia-inducible factors regulate human and rat cystathionine b-synthase gene expression. Biochem J. 2013-12-12 [PMID: 24328859] (WB, Chemotaxis, Rat, Human)	WB, Chemotaxis	Rat, Human
Bocca C, Ievolella M, Autelli R et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin Ther Targets 2014-02-01 [PMID: 24325753] (IHC-P, Human)	IHC-P	Human
Chen Z, He X, Xia W et al. Prognostic Value and Clinicopathological Differences of HIFs in Colorectal Cancer: Evidence from Meta-Analysis. PLoS One 2013-12-06 [PMID: 24324596] (IF/IHC, Human)	IF/IHC	Human
Gilkes DM, Xiang L, Lee SJ et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A 2014-01-21 [PMID: 24324133] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Chiatar SS, Eze OP, Schoenfeld AR. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation Cell Dev Biol. 2013-08-12 [PMID: 24308012] (WB, Human)	WB	Human
Glover LE, Bowers BE, Saeedi B et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A 2013-12-03 [PMID: 24248342] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Xiang L, Gilkes DM, Chaturvedi P et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2013-11-20 [PMID: 24248265]
Proper SP, Saini Y, Greenwood KK et al. Loss of hypoxia-inducible factor 2 alpha (HIF2alpha) in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci. 2013-11-11 [PMID: 24218148] (IHC-P, Mouse)	IHC-P	Mouse
Xu Z, Zhao L, Zhu LY et al. MicroRNA-17, 20a Regulates the Proangiogenic Function of Tumor-Associated Macrophages via Targeting Hypoxia-Inducible Factor 2alpha. PLoS One. 2013-10-23 [PMID: 24194900] (IHC-Fr, IHC-P, ICC/IF, WB, Human)	IHC-Fr, IHC-P, ICC/IF, WB	Human
Poitz DM, Augstein A, Hesse K et al. Regulation of the HIF-system in Human macrophages - Differential regulation of HIF-alpha subunits under sustained hypoxia. Mol Immunol. 2013-10-28 [PMID: 24176785] (WB, Human)	WB	Human
Scholz CC, Cavadas MA, Tambuwala MM et al. Regulation of IL-1beta-induced NF-kB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A. 2013-11-12 [PMID: 24145445] (WB, Human)	WB	Human
Selvarajah J, Nathawat K, Moumen A et al. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis. 2013-10-17 [PMID: 24136229] (WB, Human)	WB	Human
Nanduri J, Vaddi DR, Khan SA et al. Xanthine oxidase mediates hypoxia-inducible factor-2alpha degradation by intermittent hypoxia. PLoS One. 2013-10-04 [PMID: 24124516] (WB, Rat)	WB	Rat
Cowburn AS, Takeda N, Boutin AT et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013-10-22 [PMID: 24101470] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Eckle T, Brodsky K, Bonney M et al. HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium. PLoS Biol. 2013-09-01 [PMID: 24086109] (WB, Human)	WB	Human
Doedens AL, Phan AT, Stradner MH et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat Immunol. 2013-11-01 [PMID: 24076634] (WB, Mouse)	WB	Mouse
Cowburn AS, Alexander LE, Southwood M et al. Epidermal Deletion of HIF-2alpha Stimulates Wound Closure. J Invest Dermatol. 2013-09-13 [PMID: 24037341] (WB, Human)	WB	Human
Wei K, Piecewicz SM, McGinnis LM et al. A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013-10-01 [PMID: 24037094] (WB, Mouse)	WB	Mouse
Pawlus MR, Wang L, Murakami A. STAT3 or USF2 Contributes to HIF Target Gene Specificity. PLoS One 2013-08-21 [PMID: 23991099] (WB, Chemotaxis, Human) Details: Using the Biotin conjugated version of NB100-134, catalog number NB100-134B.	WB, Chemotaxis	Human
Luo X, Hill M, Johnson A, Latunde-Dada GO. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2alpha in cultured cells. Biochim Biophys Acta. 2013-08-24 [PMID: 23981688] (WB, Human)	WB	Human
Befani C, Mylonis I, Gkotinakou IM et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013-08-16 [PMID: 23958427] (WB, Human)	WB	Human
Hanna C, Hubchak SC, Liang X et al. Hypoxia-inducible factor-2alpha and TGF-beta signaling interact to promote normoxic glomerular fibrogenesis. Am J Physiol Renal Physiol. 2013-11-01 [PMID: 23946285] (WB, Human)	WB	Human
Regan Anderson TM, Peacock DL, Daniel AR et al. Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression. Cancer Res. 2013-09-15 [PMID: 23928995] (WB, Human)	WB	Human
Brackmann FA, Link AS, Jung S et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res 2013-07-31 [PMID: 23916668] (WB, Mouse)	WB	Mouse
Poitz DM, Augstein A, Gradehand C et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol Immunol 2013-07-31 [PMID: 23911400] (WB, Human)	WB	Human
You Q, Holt M, Yin H et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol 2013-07-19 [PMID: 23876342] (WB, Mouse)	WB	Mouse
Kim M, Park HJ, Seol JW et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013-07-12 [PMID: 23853117] (IHC-P, Mouse)	IHC-P	Mouse
Wong WJ, Qiu B, Nakazawa MS et al. MYC Degradation Under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol Cell Biol 2013-07-01 [PMID: 23816886] (WB, Human)	WB	Human
Xie L, Collins JF. Transcription Factors Sp1 and Hif2alpha Mediate Induction of the Copper-Transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells During Hypoxia. J Biol Chem 2013-06-28 [PMID: 23814049] (WB, Chemotaxis, Rat)	WB, Chemotaxis	Rat
Sato Y, Yoshizato T, Shiraishi Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 2013-06-24 [PMID: 23797736] (IF/IHC, Human)	IF/IHC	Human
Goetze O, Schmitt J, Spliethoff K et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology. 2013-06-20 [PMID: 23787477] (IHC-Fr, ICC/IF, Human)	IHC-Fr, ICC/IF	Human
Ikeda J, Ichiki T, Matsuura H et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013-06-18 [PMID: 23778187] (WB, Human)	WB	Human
Wilkinson N, Pantopoulos K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2a mRNA translation. Blood. 2013-08-29 [PMID: 23777768] (WB, Mouse)	WB	Mouse
Kerkela R, Karsikas S, Szabo Z et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol. 2013-08-01 [PMID: 23775121] (WB, Mouse)	WB	Mouse
Hubbi ME, Hu H, Kshitiz et al. Sirtuin-7 Inhibits the Activity of Hypoxia-Inducible Factors. J Biol Chem 2013-07-19 [PMID: 23750001] (WB, Human)	WB	Human
Forristal CE, Christensen DR, Chinnery FE et al. Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells. Plos One 2013-05-06 [PMID: 23671606] (Chemotaxis, Human)	Chemotaxis	Human
Thapa RJ, Chen P, Cheung M et al. NF-kB Inhibition by Bortezomib Permits IFN-y-Activated RIP1 Kinase-Dependent Necrosis in Renal Cell Carcinoma. Mol Cancer Ther. 2013-08-01 [PMID: 23657944] (WB, Human)	WB	Human
Mao XG, Xue XY, Wang L et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro Oncol 2013-05-03 [PMID: 23645533] (Chemotaxis, WB, Human)	Chemotaxis, WB	Human
Pawlus MR, Wang L, Hu CJ. STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013-04-22 [PMID: 23604114] (WB, Human)	WB	Human
Luo B, Jiang M, Yang X et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis Biochim Biophys Acta 2013-04-23 [PMID: 23603807] (WB, Rat)	WB	Rat
Matak P, Zumerle S, Mastrogiannaki M et al. Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2alpha and Altered Expression of Iron Absorption Genes in Mice PLoS One 2013-01-01 [PMID: 23555700] (WB, Mouse)	WB	Mouse
Gilkes DM, Chaturvedi P, Bajpai S et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res 2013-06-01 [PMID: 23539444] (WB, Human)	WB	Human
Mohlin S, Hamidian A, Pahlman S. HIF2A and IGF2 Expression Correlates in Human Neuroblastoma Cells and Normal Immature Sympathetic Neuroblasts Neoplasia 2013-03-01 [PMID: 23479510] (IHC-P, Human)	IHC-P	Human
Parks SK, Mazure NM, Counillon L, Pouyssegur J. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels J Cell Physiol 2013-03-04 [PMID: 23459996] (WB, Human)	WB	Human
Gonzalez-Flores A, Aguilar-Quesada R, Siles E et al. Interaction between PARP-1 and HIF-2alpha in the hypoxic response. Oncogene 2013-03-04 [PMID: 23455322] (WB, IP, Mouse, Human)	WB, IP	Mouse, Human
Fu L, Wang G, Shevchuk MM et al. Activation of HIF2alpha in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis. Cancer Res 2013-05-01 [PMID: 23447580] (IF/IHC, Mouse)	IF/IHC	Mouse
Maruyama T, Miyamoto Y, Yamamoto G et al. Downregulation of Carbonic Anhydrase IX Promotes Col10a1 Expression in Chondrocytes. PLoS One 2013-01-01 [PMID: 23441228] (WB, Mouse)	WB	Mouse
Choi HJ, Sanders TA, Tormos KV et al. ECM-Dependent HIF Induction Directs Trophoblast Stem Cell Fate via LIMK1-Mediated Cytoskeletal Rearrangement. PLoS One 2013-01-01 [PMID: 23437279] (WB, Mouse)	WB	Mouse
Finger EC, Cheng CF, Williams TR et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013-02-25 [PMID: 23435419] (WB, Human)	WB	Human
Gilkes DM, Bajpai S, Chaturvedi P et al. HIF-1 Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J Biol Chem 2013-02-19 [PMID: 23423382] (WB, Human)	WB	Human
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Yeh IJ. HEXIM1 IS AN INHIBITOR OF TWO TRANSCRIPTION FACTORS CRITICAL IN CANCER: THE ANDROGEN RECEPTOR AND HYPOXIA INDUCIBLE FACTOR-1 ALPHA Thesis. 2015-01-01 (WB, Human)	WB	Human
Sasabe E, Tomomura A, Hamada M. Nitric Oxide Attenuates Hypoxia-Induced 5-FU Resistance of Oral Squamous Cell Carcinoma Cells International Journal ofCancer and Clinical Research 2015-01-01 (IHC-P, Human)	IHC-P	Human
Kostyunina D Sex differences in the pulmonary microvascular endothelial responses to hypoxia under physiological shear stress Thesis 2022-01-01
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Gerber MM. The Identification of Colorectal Cancer Susceptibility Genes Using a Cross-Species, Systems Genetics Approach. Thesis. 2015-01-01 (WB, Human)	WB	Human
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Tawari EP. Investigation of chemoresistant mechanisms in triple negative breast. Thesis. 2016-03-01 (WB, ICC/IF, Human)	WB, ICC/IF	Human
Yin H Chronic Hypoxia Impairs Skeletal Muscle Repair via HIF-2? Stabilization https://www.authorea.com/ 2023-10-02 (IHC, Mouse)	IHC	Mouse
Ting KKY Lipid Loading of Macrophages Repurposes NADPH Metabolism to Suppress Glycolysis and Inflammation Thesis 2023-01-01
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Fujimoto TN, Colbert LE, Molkentine JM, Baseler L. EGLN Inhibition Reduces Gastrointestinal Radiation Toxicity and Improves Survival in a Murine Model of Locally Advanced Pancreatic Cancer bioRxiv 2018-07-20 (WB, Mouse)	WB	Mouse
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Asikainen, TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells explants of primate lung. PNAS 102(29): 10212-10217. 2005-01-01 [PMID: 16009933] (WB, Human)	WB	Human
Maltepe E, Krampitz GW, Okazaki KM et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005-08-01 [PMID: 15987772] (WB, Mouse)	WB	Mouse
Smith, K et al. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res;65 (12):5221-30. 2005-06-15 [PMID: 15958567] (WB, Mouse)	WB	Mouse
Temes, E et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J Biol Chem;280(25):24238-44. 2005-06-24 [PMID: 15849364] (WB, Human)	WB	Human
Miller, F et al. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL. J Biol Chem.280(9):7985-96. 2005-03-04 [PMID: 15611064] (WB, Human)	WB	Human
Petrella BL, Lohi J, Brinckerhoff CE. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005-02-03 [PMID: 15592504] (ELISA, Human)	ELISA	Human
Rathmell WK, Hickey MM, Bezman NA, Chmielecki CA, Carraway NC, Simon MC. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res;64(23):8595-603. 2004-12-01 [PMID: 15574766] (IB, IP, Mouse)	IB, IP	Mouse
Tang, N,et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell;6 (5):485-95. 2004-11-01 [PMID: 15542432] (WB, Mouse)	WB	Mouse
Freeburg, P et al. Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. J Am Soc Nephrol;15(10):2569-78. 2004-10-01 [PMID: 15466261] (WB, Mouse)	WB	Mouse
Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol;24(20):9038-47. 2004-10-01 [PMID: 15456877] (WB, Mouse)	WB	Mouse
Rajakumar A, Brandon HM, Daftary A et al. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004-11-01 [PMID: 15451190] (WB, Human)	WB	Human
Takeda, N et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ Res;95(2):146-53. 2004-07-23 [PMID: 15192019] (WB)	WB
Grabmaier, K et al. Strict regulation of CAIXG250/MN by HIF-1 alpha in clear cell renal cell carcinoma. Oncogene;23(33):5624-31. 2004-07-22 [PMID: 15184875] (GS, Human)	GS	Human
Mekhail, K et al. HIF activation by pH-dependent nucleolar sequestration of VHL. Nature Cell Biology. 6: 642-647. 2004-01-01 [PMID: 15181450]
Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene;23(29):4975-83. 2004-06-24 [PMID: 15107830] (WB, Mouse)	WB	Mouse
Sato, M et al. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol;31 (2):209-15. 2004-08-01 [PMID: 15039136]
Welsh, S et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther;3(3):233-44. 2004-03-01 [PMID: 15026543] (IHC-P, Mouse)	IHC-P	Mouse
Mizukami, Y et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res;64 (5):1765-72. 2004-03-01 [PMID: 14996738] (WB, Human)	WB	Human
Zimmer, M et al. Inhibition of Hypoxia-Inducible Factor Is Sufficient for Growth Supression of VHL-/- Tumors. Molecular Cancer Research 2: 89-95. 2004-01-01 [PMID: 14985465] (WB, Human)	WB	Human
Uchida T, Rossignol F, Matthay MA et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 2004-04-09 [PMID: 14744852] (IB, Human)	IB	Human
Martin-Puig S, Temes E, Olmos G, Jones DR, Aragones J, Landazuri MO. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J Biol Chem;279(10):9504-11. 2004-03-05 [PMID: 14681229] (WB, Human)	WB	Human
Hu CJ, Wang LY, Chodosh LA et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003-12-01 [PMID: 14645546] (WB)	WB
Yuan HT, Li XZ, Pitera JE et al. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am J Pathol 2003-12-01 [PMID: 14633603] (IHC-P, WB, Mouse)	IHC-P, WB	Mouse
Cuevas Y, Hernandez-Alcoceba R, Aragones J, Naranjo-Suarez S, Castellanos MC, Esteban MA, Martin-Puig S, Landazuri MO, del Peso L. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res;63(20):6877-84. 2003-10-15 [PMID: 14583486] (WB, Human)	WB	Human
Corn PG, McDonald ER 3rd, Herman JG, El-Deiry WS. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genet;35(3):229-37. 2003-11-01 [PMID: 14556007]
Peso, L et al. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem;278(49):48690-5. 2003-12-05 [PMID: 14506252] (WB, Human)	WB	Human
Staller, P et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature;425(6955):307-11. 2003-09-18 [PMID: 13679920] (WB, Human)	WB	Human
Mohan, S et al. von Hippel-Linau protein complex is regulated by cell density. Oncogene 22: 5270-5280. 2003-01-01 [PMID: 12917628] (WB, Human)	WB	Human
Palayoor, S et al. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res;9 (8):3150-7. 2003-08-01 [PMID: 12912967] (WB, Human)	WB	Human
Mabjeesh, N et al. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res;9(7):2416-25. 2003-07-01 [PMID: 12855613] (WB, Human)	WB	Human
Park, S et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol;23(14):4959-71. 2003-07-01 [PMID: 12832481] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Naranjo-Suarez, S et al. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J Biol Chem;278(34):31895-901. 2003-08-22 [PMID: 12805361] (WB, Rat)	WB	Rat
Liu MY, Poellinger L, Walker CL. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 2003-05-15 [PMID: 12750296] (Rat)		Rat
Baba M, Hirai S, Yamada-Okabe H et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene 2003-05-08 [PMID: 12743597] (WB, Human)	WB	Human
Mabjeesh, N et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell;3(4):363-75. 2003-04-01 [PMID: 12726862] (WB, Human)	WB	Human
Khatua, S et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res;63(8):1865-70. 2003-04-15 [PMID: 12702575] (IHC-P, Human)	IHC-P	Human
Graven,K et al. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim Biophys Acta;1626(1-3):10-8. 2003-04-15 [PMID: 12697324]
Toro, R et al. Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem;278(25):22316-24. 2003-06-20 [PMID: 12679337] (WB, Rat)	WB	Rat
Yuan, Y et al. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem;278(18):15911-6. 2003-05-02 [PMID: 12606543] (WB, Rat)	WB	Rat
Mack, F et al. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell;3(1):75-88. 2003-01-01 [PMID: 12559177] (WB, Mouse)	WB	Mouse
Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem;277(42):40112-7. 2002-10-18 [PMID: 12186875] (WB, Human)	WB	Human
Bernaudin, M et al. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 277(42):39728-38. 2002-10-18 [PMID: 12145288] (WB, Rat)	WB	Rat
Maranchie, J et al. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell;1(3):247-55. 2002-04-01 [PMID: 12086861] (WB, Human)	WB	Human
Kondo, K et al. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell;1(3):237-46. 2002-04-01 [PMID: 12086860] (WB, Human)	WB	Human
Xia G et al. (2002) Positive expression of HIF-2alpha/ EPAS1 in invasive bladder cancer. Urology;59(5):774-8. 2002-05-01 [PMID: 11992927] (WB, Chemotaxis, Human)	WB, Chemotaxis	Human
Liang, Y et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J Biol Chem;277(22):20087-94. 2002-05-31 [PMID: 11912213]
Alvarez-Tejado M, Alfranca A, Aragones J et al. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem;277(16):13508-17. 2002-04-19 [PMID: 11815624] (WB, Human)	WB	Human
Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol;196(2):204-12. 2002-02-01 [PMID: 11793372]
Michenko, A et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem. 277(8):6183-7. 2002-02-22 [PMID: 11744734]
Makino, Y et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature;414(6863):550-4. 2001-11-29 [PMID: 11734856]
Ad N, Snir E, Vidne BA, Golomb E. Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ann Thorac Surg;72(3):688-93. 2001-09-01 [PMID: 11565642] (IHC-P, Human)	IHC-P	Human
Luo JC, Shibuya M. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene;20(12):1435-44. 2001-03-22 [PMID: 11313887]
Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C et al. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem;276(25):22368-74. 2001-06-22 [PMID: 11294857] (WB, Mouse)	WB	Mouse
Haase, VH et al. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A;98(4):1583-8. 2001-02-13 [PMID: 11171994]
de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci U S A;98(4):1387-92. 2001-02-13 [PMID: 11171960] (FLOW, WB, Human)	FLOW, WB	Human
Bonicalzi ME, Groulx I, de Paulsen N, Lee S. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J Biol Chem;276(2):1407-16. 2001-01-12 [PMID: 11024059] (WB, IP, Human)	WB, IP	Human
Rajakumar, A, Conrad, K. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod;63 (2):559-69. 2000-08-01 [PMID: 10906065] (WB, IHC-P, Human)	WB, IHC-P	Human
Ohh, M et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol;2(7):423-7. 2000-07-01 [PMID: 10878807]
Conrad PW, Freeman TL, Beitner-Johnson D et al. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J Biol Chem;274(47):33709-13. 1999-11-19 [PMID: 10559262] (WB, IP, Rat)	WB, IP	Rat
Baba M, Hirai S, Yamada-Okabe H et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene;22(18):2728-38. 2003-05-08 [PMID: 1274359] (WB, Human)	WB	Human
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Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	01/11/2024	View Summary Application Western Blot Sample Tested mouse liver Species Mouse Lot C7 Pub Med ID 38652538 Comments Comments Nuclear extracts using Nuclear and Cytoplasmic Extraction Reagents
	5 reviewed by: Daiana Drehmer	WB	Human	10/05/2022	View Summary Application Western Blot Sample Tested Hep3B human hepatocellular carcinoma cell line Species Human Lot CO-5
Enlarge	5 reviewed by: Verified Customer	WB	Human	03/15/2021	View Summary Application Western Blot Sample Tested Hep3B human hepatocellular carcinoma cell line Species Human Lot CI-3
	5 reviewed by: Verified Customer	WB	Human	07/05/2019	View Summary Application Western Blot Sample Tested Human cancer cell lines Species Human Lot CF
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/16/2019	View Summary Application Western Blot Sample Tested HBE-16 Species Human Lot CD-9
	5 reviewed by: Verified Customer	WB	Human	02/04/2019	View Summary Application Western Blot Sample Tested cultured cells Species Human Lot Bv-02
	4 reviewed by: Verified Customer	WB	Human	02/02/2019	View Summary Application Western Blot Sample Tested 786O cell lysates Species Human Lot BP2
Enlarge	3 reviewed by: Verified Customer	ChIP	Human	12/02/2018	View Summary Application Chromatin Immunoprecipitation Sample Tested MCF7 cell line Species Human Lot CD-13
Enlarge	4 reviewed by: Verified Customer	WB	Human	09/18/2018	View Summary Application Western Blot Sample Tested Human Cancer Cells Species Human Lot N/A
Enlarge	5 reviewed by: Verified Customer	WB	Human	05/11/2018	View Summary Application Western Blot Sample Tested 293T HEK cell lysate Species Human Lot CD-2 Comments Comments Antibody dilution- 1:500 in 5% BSA- overnight 4 degerees
	5 reviewed by: Shanhai Xie	WB	Mouse	01/12/2017	View Summary Application Western Blot Sample Tested transfected U2OS cell lysate Species Mouse Lot BV-2
	5 reviewed by: Verified Customer	WB	Human	01/12/2017	View Summary Application Western Blot Sample Tested cultured cells Species Human Lot BV-2
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	10/18/2016	View Summary Application Western Blot Sample Tested Mouse CD4+ T Cells Species Mouse Lot BP-1 Comments Comments Dilution (1:1000)
Enlarge	5 reviewed by: Helder Andre	WB	Human	07/11/2016	View Summary Application Western Blot Sample Tested Retinal and Choroidal primary endothelia Species Human
Enlarge	5 reviewed by: Verified Customer	WB	Human	03/31/2016	View Summary Application Western Blot Sample Tested HCT116 cell line lysate Species Human Lot BP-2
Enlarge	4 reviewed by: Verified Customer	WB	Human	11/10/2015	View Summary Application Western Blot Sample Tested cytoplasmic and nuclear protein fractions of U266 cells Species Human
Enlarge	4 reviewed by: Verified Customer	WB	Human	08/12/2015	View Summary Application Western Blot Sample Tested Primary Epithelial Cells Species Human
Enlarge	5 reviewed by: Verified Customer	WB	Human	06/01/2015	View Summary Application Western Blot Sample Tested MDA-MB-231 Cell Lysate Species Human Lot BQ1
	4 reviewed by: Verified Customer	WB	Human	03/27/2015	View Summary Application Western Blot Sample Tested 786O cell lysates Species Human
	4 reviewed by: Verified Customer	ChIP	Human	12/12/2014	View Summary Application Chromatin Immunoprecipitation Sample Tested See PMID:24248342 Species Human
	4 reviewed by: Verified Customer	WB	Human	12/12/2014	View Summary Application Western Blot Sample Tested See PMID:24308012 Species Human
Enlarge	4 reviewed by: Xiuquan Luo	WB	Human	09/12/2014	View Summary Application Western Blot Sample Tested HEK293 cell lysate Species Human
Enlarge	4 reviewed by: Pramod Mallikarjuna	WB	Human	08/30/2014	View Summary Application Western Blot Sample Tested Clear cell renal cell carcinoma samples Species Human
	4 reviewed by: Verified Customer	WB	Other	07/26/2014	View Summary Application Western Blot Sample Tested PC12 whole cell lysate Species Other Lot BR-1
	5 reviewed by: Verified Customer	WB	Human	06/30/2014	View Summary Application Western Blot Sample Tested Whole cell lysate Species Human
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/30/2014	View Summary Application Western Blot Sample Tested whole cell lysate U87MG (human glioblastoma cells) Species Human
Enlarge	4 reviewed by: Saori Yoshii	IHC-P	Mouse	04/11/2014	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse Intestine Species Mouse Lot BP-1
	4 reviewed by: Verified Customer	WB	Other	04/04/2014	View Summary Application Western Blot Sample Tested SH-SY5Y whole cell lysate Species Other Lot BP-1
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/03/2014	View Summary Application Western Blot Species Human Lot BP-1
Enlarge	4 reviewed by: Prabir Chakraborty	WB	Human	01/24/2014	View Summary Application Western Blot Sample Tested UNTREATED OVARIAN SURFACE EPITHELIUM CELLS (OSE) AND A2780 CELLS LYSATES 25ug Species Human Lot BB1
Enlarge	4 reviewed by: Verified Customer	WB	Human	11/20/2013	View Summary Application Western Blot Sample Tested Human Glioma cells, whole cell lysates Species Human Lot BN-1
Enlarge	4 reviewed by: Verified Customer	IF	Mouse	04/15/2013	View Summary Application Immunofluorescence Species Mouse
Enlarge	5 reviewed by: Verified Customer	ChIP	Rat	04/02/2013	View Summary Application Chromatin Immunoprecipitation Species Rat
Enlarge	4 reviewed by: Verified Customer	WB		09/19/2012	View Summary Application Western Blot Lot BK-2
	5 reviewed by: Verified Customer	WB	Mouse	12/08/2011	View Summary Application Western Blot Sample Tested Mouse Species Mouse
Enlarge	5 reviewed by: Olga Razorenova	WB	Human	06/15/2011	View Summary Application Western Blot Sample Tested ACHN, SN12C, Caki1 whole cell lysates, Sample Amount: 30ug Species Human Lot BC3
	3 reviewed by: Verified Customer	WB	Other	03/11/2010	View Summary Application Western Blot Sample Tested Colon Cancer Cell llines, Sample Amount: 50ug Species Other Lot AT1
	3 reviewed by: Verified Customer	WB	Other	02/09/2009	View Summary Application Western Blot Sample Tested head and neck squamous cell carcinoma cells, Sample Amount: 35 ug Species Other
	3 reviewed by: Verified Customer	IHC-P	Human	02/02/2009	View Summary Application Immunohistochemistry-Paraffin Sample Tested human melanoma Species Human Lot AI