Mouse Erythropoietin/EPO Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Erythropoietin (Epo) is a 34-39 kDa secreted glycoprotein that is a member of the type I cytokine superfamily. The mouse Epo gene encodes a 192 amino acid (aa) residue precursor that contains a 26 aa signal peptide and a 166 aa mature protein containing three potential N-linked glycosylation sites (1-4). Mouse Epo lacks the O-linked glycosylation site found in human Epo. Although carbohydrate chains are not required for in vitro receptor binding, they are required for in vivo Epo bioactivity. Depending on the cell source, different Epo isoforms are produced that differ in their glycan compositions and sialic acid contents (5-8). Mature mouse and rat Epo share 94% aa sequence identity. They also share from 80%-82% aa identity with mature human, porcine, rhesus monkey and feline Epo (2, 3). Epo is primarily produced by cells in the kidney (interstitial peritubular renal fibroblasts) and liver (hepatocytes and Ito cells), where its production is up-regulated by hypoxia. Other tissues and cells, including neural tissues (astrocytes and neurons), testis (Sertoli cells), uterus, placenta, and erythroid progenitors, have also been shown to produce Epo (9-14). 

We have publications tested in 3 confirmed species: Mouse, Rat, Transgenic Mouse.

Showing Publications 1 - 10 of 105. Show All 105 Publications. Collapse Publications.

Publications using MEP00B	Applications	Species
An, W;Feola, M;Levy, M;Aluri, S;Ruiz-Martinez, M;Sridharan, A;Fibach, E;Zhu, X;Verma, A;Ginzburg, Y; Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice eLife 2023-12-28 [PMID: 38153418] (Mouse)		Mouse
Duarte, TL;Lopes, M;Oliveira, M;Santos, AG;Vasco, C;Reis, JP;Antunes, AR;Gonçalves, A;Chacim, S;Oliveira, C;Porto, B;Teles, MJ;Moreira, AC;Silva, AMN;Schwessinger, R;Drakesmith, H;Henrique, R;Porto, G;Duarte, D; Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice Leukemia 2023-10-19 [PMID: 37857886] (Mouse)		Mouse
Holmes-Hampton, GP;Kumar, VP;Biswas, S;Stone, S;Sharma, NK;Legesse, B;Vercellino, J;Guha, C;Eichenbaum, G;Ghosh, SP; PEGylated thrombopoietin mimetic, JNJ?26366821 a novel prophylactic radiation countermeasure for acute radiation injury Scientific reports 2023-09-14 [PMID: 37709916] (Mouse)		Mouse
Matte, A;Wilson, AB;Gevi, F;Federti, E;Recchiuti, A;Ferri, G;Brunati, AM;Pagano, MA;Russo, R;Leboeuf, C;Janin, A;Timperio, AM;Iolascon, A;Gremese, E;Dang, L;Mohandas, N;Brugnara, C;De Franceschi, L; Mitapivat reprograms red cell metabolome and improves anemia in a mouse model of hereditary spherocytosis JCI insight 2023-09-07 [PMID: 37676741] (Transgenic Mouse, Mouse)		Transgenic Mouse, Mouse
Pegka, F;Ben-Califa, N;Neumann, D;Jäkel, H;Hengst, L; EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27Kip1 Cells 2023-06-23 [PMID: 37443738] (Mouse)		Mouse
M Subramania, J McIninch, I Zlatev, MK Schlegel, C Kaittanis, T Nguyen, S Agarwal, T Racie, MA Alvarado, K Wassarman, TS Collins, T Chickering, CR Brown, K Schmidt, AB Castoreno, S Shulga-Mor, E Stamenova, K Buckowing, D Berman, JD Barry, A Bisbe, MA Maier, K Fitzgerald, V Jadhav RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes Nature Communications, 2023-04-08;14(1):1970. 2023-04-08 [PMID: 37031257] (Mouse)		Mouse
E Hamza, M Vallejo-Mu, H Ouled-Hadd, C García-Cab, M Guerrero-H, L Santier, S Rayego-Mat, IA Larabi, JC Alvarez, L Garçon, ZA Massy, G Choukroun, JA Moreno, L Metzinger, VM Meuth Indoxyl sulfate impairs erythropoiesis at BFU-E stage in chronic kidney disease Cellular Signalling, 2022-12-31;0(0):110583. 2022-12-31 [PMID: 36596353] (Mouse)		Mouse
J Yang, Y Ruan, D Wang, J Fan, N Luo, H Chen, X Li, W Chen, X Wang VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2alpha Cell & bioscience, 2022-12-19;12(1):203. 2022-12-19 [PMID: 36536448] (Mouse)		Mouse
VP Kumar, S Biswas, GP Holmes-Ham, M Sheleg, S Stone, B Legesse, R Ofir, SP Ghosh Pre-Administration of PLX-R18 Cells Protects Mice from Radiation-Induced Hematopoietic Failure and Lethality Genes, 2022-09-28;13(10):. 2022-09-28 [PMID: 36292639] (Mouse)		Mouse
J Tapio, R Halmetoja, EY Dimova, JM Mäki, A Laitala, G Walkinshaw, J Myllyharju, R Serpi, P Koivunen Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism The Journal of Biological Chemistry, 2022-07-01;0(0):102222. 2022-07-01 [PMID: 35787374] (Mouse)		Mouse
N Sissala, E Myllymäki, F Mohr, R Halmetoja, P Kuvaja, EY Dimova, P Koivunen Hypoxia ameliorates maternal diet-induced insulin resistance during pregnancy while having a detrimental effect on the placenta Physiological Reports, 2022-05-01;10(9):e15302. 2022-05-01 [PMID: 35535947] (Mouse)		Mouse
MR Hanudel, B Czaya, S Wong, G Jung, K Chua, B Qiao, V Gabayan, T Ganz Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease Scientific Reports, 2022-04-23;12(1):6695. 2022-04-23 [PMID: 35461329] (Mouse)		Mouse
D Zhang, X Gao, H Li, DK Borger, Q Wei, E Yang, C Xu, S Pinho, PS Frenette The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow Cell Stem Cell, 2022-01-21;0(0):. 2022-01-21 [PMID: 35065706] (Mouse)		Mouse
J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation Nature Communications, 2021-11-29;12(1):6963. 2021-11-29 [PMID: 34845225] (Mouse)		Mouse
HM Shih, SY Pan, CJ Wu, YH Chou, CY Chen, FC Chang, YT Chen, WC Chiang, HC Tsai, YM Chen, SL Lin Transforming growth factor-beta1 decreases erythropoietin production through repressing hypoxia-inducible factor 2alpha in erythropoietin-producing cells Journal of Biomedical Science, 2021-11-02;28(1):73. 2021-11-02 [PMID: 34724959] (Mouse)		Mouse
R Torosyan, S Huang, PV Bommi, R Tiwari, SY An, M Schonfeld, G Rajendran, MA Kavanaugh, B Gibbs, AD Truax, S Bohney, MW Calcutt, EW Kerr, R Leonardi, P Gao, NS Chandel, PP Kapitsinou Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway Cell Reports, 2021-08-17;36(7):109547. 2021-08-17 [PMID: 34407414] (Mouse)		Mouse
A Mattebo, T Sen, M Jassinskaj, K Pimková, I Prieto Gon, AG Alattar, R Ramakrishn, S Lang, M Järås, J Hansson, S Soneji, S Singbrant, E van den Ak, J Flygare Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity Scientific Reports, 2021-08-05;11(1):15898. 2021-08-05 [PMID: 34354145] (Mouse)		Mouse
AM Monteys, AA Hundley, PT Ranum, L Tecedor, A Muehlmatt, E Lim, D Lukashev, R Sivasankar, BL Davidson Regulated control of gene therapies by drug-induced splicing Nature, 2021-07-28;0(0):. 2021-07-28 [PMID: 34321659] (Mouse)		Mouse
YD Pettway, TH Neder, DH Ho, BM Fox, M Burch, J Colson, X Liu, CE Kellum, KA Hyndman, JS Pollock Early life stress induces dysregulation of the heme pathway in adult mice Physiological Reports, 2021-05-01;9(10):e14844. 2021-05-01 [PMID: 34042301] (Mouse)		Mouse
I Bandach, Y Segev, D Landau Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia Scientific Reports, 2021-03-18;11(1):6288. 2021-03-18 [PMID: 33737665] (Mouse)		Mouse
AK Persaud, S Nair, MF Rahman, R Raj, B Weadick, D Nayak, C McElroy, M Shanmugam, S Knoblaugh, X Cheng, R Govindaraj Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors Nature Communications, 2021-02-23;12(1):1248. 2021-02-23 [PMID: 33623001] (Mouse)		Mouse
R Maekawa, H Muto, M Hatayama, J Aruga Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice PLoS ONE, 2021-01-22;16(1):e0245624. 2021-01-22 [PMID: 33481887] (Mouse)		Mouse
G Xu, R van Brugge, CO Gualtieri, N Moradin, A Fois, D Vallerand, M De Sa Tava, A Bassenden, W Lu, M Tam, S Lesage, H Girouard, DZ Avizonis, G Deblois, JT Prchal, M Stevenson, A Berghuis, T Muir, J Rabinowitz, SM Vidal, N Fodil, P Gros Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia Cell Rep, 2020-09-22;32(12):108170. 2020-09-22 [PMID: 32966787] (Mouse)		Mouse
J Varghese, JV James, R Anand, M Narayanasa, G Rebekah, B Ramakrishn, AJ Nellickal, M Jacob Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet J. Nutr. Biochem., 2020-06-02;84(0):108441. 2020-06-02 [PMID: 32629238] (Mouse)		Mouse
ML Noonan, EL Clinkenbea, P Ni, EA Swallow, SP Tippen, R Agoro, MR Allen, KE White Erythropoietin and a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHDi) lowers FGF23 in a model of chronic kidney disease (CKD) Physiol Rep, 2020-06-01;8(11):e14434. 2020-06-01 [PMID: 32476270] (Mouse)		Mouse
N Chakrabort, A Gautam, GP Holmes-Ham, VP Kumar, S Biswas, R Kumar, D Hamad, G Dimitrov, AO Olabisi, R Hammamieh, SP Ghosh microRNA and Metabolite Signatures Linked to Early Consequences of Lethal Radiation Sci Rep, 2020-03-25;10(1):5424. 2020-03-25 [PMID: 32214144] (Mouse)		Mouse
R Agoro, MY Park, C Le Henaff, S Jankauskas, A Gaias, G Chen, M Mohammadi, D Sitara C-FGF23 peptide alleviates hypoferremia during acute inflammation Haematologica, 2021-02-01;0(0):. 2021-02-01 [PMID: 32193252] (Mouse)		Mouse
S Shibuya, T Toda, Y Ozawa, MJV Yata, T Shimizu Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice Nutrients, 2020-02-19;12(2):. 2020-02-19 [PMID: 32092924] (Mouse)		Mouse
EM Buhl, S Djudjaj, BM Klinkhamme, K Ermert, VG Puelles, MT Lindenmeye, CD Cohen, C He, E Borkham-Ka, R Weiskirche, B Denecke, P Trairatphi, J Saez-Rodri, TB Huber, LE Olson, J Floege, P Boor Dysregulated mesenchymal PDGFR-&beta drives kidney fibrosis EMBO Mol Med, 2020-01-14;0(0):e11021. 2020-01-14 [PMID: 31943786] (Mouse)		Mouse
Nagati J, Xu M, Garcia T, Comerford S, Hammer R, Garcia J A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling. PLoS ONE, 2019-11-14;14(11):e0225105. 2019-11-14 [PMID: 31725783] (Mouse)		Mouse
C Casu, R Chessa, A Liu, R Gupta, H Drakesmith, R Fleming, YZ Ginzburg, B MacDonald, S Rivella Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult beta-thalassemia major Haematologica, 2019-10-03;0(0):. 2019-10-03 [PMID: 31582543] (Mouse)		Mouse
S Altamura, NM Vegi, PS Hoppe, T Schroeder, M Aichler, A Walch, K Okreglicka, L Hültner, M Schneider, C Ladinig, C Kuklik-Roo, J Mysliwietz, D Janik, F Neff, B Rathkolb, M Hrabé de A, C Buske, AR da Silva, K Muedder, M Conrad, T Ganz, M Kopf, MU Muckenthal, GW Bornkamm Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248967] (Mouse)		Mouse
K Itoh, S Masumori, D Mukai, H Sakakibara, M Yasuda, K Shimoi Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin J Toxicol Sci, 2019-01-01;44(4):273-282. 2019-01-01 [PMID: 30944280] (Mouse)		Mouse
X Wang, M Zhang, SRL Flores, RR Woloshun, C Yang, L Yin, P Xiang, X Xu, MD Garrick, S Vidyasagar, D Merlin, JF Collins Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis Mol. Ther., 2019-01-12;0(0):. 2019-01-12 [PMID: 30713087] (Mouse)		Mouse
S Carvalho, M Ferrini, L Herritt, A Holian, Z Jaffar, K Roberts Multi-Walled Carbon Nanotubes Augment Allergic Airway Eosinophilic Inflammation by Promoting Cysteinyl Leukotriene Production Front Pharmacol, 2018-06-05;9(0):585. 2018-06-05 [PMID: 29922162] (Mouse)		Mouse
TL Chen, YW Chiang, GL Lin, HH Chang, TS Lien, MH Sheh, DS Sun Different effects of granulocyte colony-stimulating factor and erythropoietin on erythropoiesis Stem Cell Res Ther, 2018-05-02;9(1):119. 2018-05-02 [PMID: 29720275] (Mouse)		Mouse
R Agoro, A Montagna, R Goetz, O Aligbe, G Singh, LM Coe, M Mohammadi, S Rivella, D Sitara Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia FASEB J., 2018-02-26;0(0):fj201700667R. 2018-02-26 [PMID: 29481308] (Mouse)		Mouse
I Flamme, P Ellinghaus, D Urrego, T Krüger FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase PLoS ONE, 2017-10-26;12(10):e0186979. 2017-10-26 [PMID: 29073196] (Rat)		Rat
T Takagishi, M Takehara, S Seike, K Miyamoto, K Kobayashi, M Nagahama Clostridium perfringens ?-toxin impairs erythropoiesis by inhibition of erythroid differentiation Sci Rep, 2017-07-12;7(1):5217. 2017-07-12 [PMID: 28701754] (Mouse)		Mouse
S Guo, X Jiang, Y Wang, L Chen, H Li, X Li, Y Jia The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis Cell. Signal., 2017-07-08;38(0):106-115. 2017-07-08 [PMID: 28697999] (Mouse)		Mouse
K Gerl, D Steppan, M Fuchs, C Wagner, C Willam, A Kurtz, B Kurt Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development Am. J. Pathol., 2017-05-17;0(0):. 2017-05-17 [PMID: 28527294] (Mouse)		Mouse
H Shima, K Sasaki, T Suzuki, C Mukawa, T Obara, Y Oba, A Matsuo, T Kobayashi, E Mishima, S Watanabe, Y Akiyama, K Kikuchi, T Matsuhashi, Y Oikawa, F Nanto, Y Akiyama, HJ Ho, C Suzuki, D Saigusa, A Masamune, Y Tomioka, T Masaki, S Ito, KI Hayashi, T Abe A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-? and TGF-?1 pathways Sci Rep, 2017-05-15;7(1):1884. 2017-05-15 [PMID: 28507324] (Mouse)		Mouse
L Wang, H Yu, H Cheng, K He, Z Fang, L Ge, T Cheng, Y Jin Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver Cell Death Dis, 2017-03-30;8(3):e2722. 2017-03-30 [PMID: 28358362] (Mouse)		Mouse
TW Seeley, MD Sternlicht, SJ Klaus, TB Neff, DY Liu Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer Hypoxia (Auckl), 2017-03-10;5(0):1-9. 2017-03-10 [PMID: 28331872] (Mouse)		Mouse
K Oshima, Y Ikeda, Y Horinouchi, H Watanabe, H Hamano, Y Kihira, S Kishi, Y Izawa-Ishi, L Miyamoto, T Hirayama, H Nagasawa, K Ishizawa, K Tsuchiya, T Tamaki Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation Lab. Invest, 2017-03-06;0(0):. 2017-03-06 [PMID: 28263291] (Mouse)		Mouse
S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth Sci Rep, 2017-02-14;7(0):42301. 2017-02-14 [PMID: 28195189] (Rat)		Rat
Hypoxia sensing through ?-adrenergic receptors JCI Insight, 2016-12-22;1(21):e90240. 2016-12-22 [PMID: 28018974] (Mouse)		Mouse
Renal Anemia Model Mouse Established by Transgenic Rescue with Erythropoietin Gene Lacking Kidney-specific Regulatory Elements Mol. Cell. Biol, 2017-02-01;0(0):. 2017-02-01 [PMID: 27920250] (Mouse)		Mouse
Human CD133(+) Renal Progenitor Cells Induce Erythropoietin Production and Limit Fibrosis After Acute Tubular Injury Sci Rep, 2016-11-17;6(0):37270. 2016-11-17 [PMID: 27853265] (Mouse)		Mouse
Notch downregulation and extramedullary erythrocytosis in HIF prolyl 4-hydroxylase-2-deficient mice Mol. Cell. Biol., 2017-01-04;0(0):. 2017-01-04 [PMID: 27821476] (Mouse)		Mouse
Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice Stem Cell Reports, 2016-09-08;0(0):. 2016-09-08 [PMID: 27618723] (Mouse)		Mouse
Salmonella infection enhances erythropoietin production by the kidney and liver correlating with elevated bacterial burdens Infect Immun, 2016-09-19;0(0):. 2016-09-19 [PMID: 27456828] (Mouse)		Mouse
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution Nat Commun, 2016-07-11;7(0):12177. 2016-07-11 [PMID: 27397585] (Mouse)		Mouse
Patrick R Arsenault The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 is Essential for Efficient Hydroxylation of Hypoxia Inducible Factor-? Mol Cell Biol, 2016-08-26;0(0):. 2016-08-26 [PMID: 27325674] (Mouse)		Mouse
G Hoppe, S Yoon, B Gopalan, AR Savage, R Brown, K Case, A Vasanji, ER Chan, RB Silver, JE Sears Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity Proc Natl Acad Sci USA, 2016-04-18;0(0):. 2016-04-18 [PMID: 27091985] (Mouse)		Mouse
RB Hamanaka, SE Weinberg, CR Reczek, NS Chandel The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia Cell Rep, 2016-04-07;15(3):451-9. 2016-04-07 [PMID: 27068470] (Mouse)		Mouse
AC Selfridge, MA Cavadas, CC Scholz, EL Campbell, LC Welch, E Lecuona, SP Colgan, KE Barrett, PH Sporn, JI Sznajder, EP Cummins, CT Taylor Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia J Biol Chem, 2016-04-04;0(0):. 2016-04-04 [PMID: 27044749] (Mouse)		Mouse
T Kamio, BW Gu, TS Olson, Y Zhang, PJ Mason, M Bessler Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis PLoS ONE, 2016-04-04;11(4):e0152263. 2016-04-04 [PMID: 27042854] (Mouse)		Mouse
Canli O, Alankus Y, Grootjans S, Vegi N, Hultner L, Hoppe P, Schroeder T, Vandenabeele P, Bornkamm G, Greten F Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood, 2015-10-13;127(1):139-48. 2015-10-13 [PMID: 26463424] (Mouse)		Mouse
Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS ONE, 2014-11-13;9(11):e111838. 2014-11-13 [PMID: 25392999] (Rat)		Rat
Le Guiner C, Stieger K, Toromanoff A, Guilbaud M, Mendes-Madeira A, Devaux M, Guigand L, Cherel Y, Moullier P, Rolling F, Adjali O Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates. PLoS ONE, 2014-09-23;9(9):e102538. 2014-09-23 [PMID: 25248159] (Mouse)		Mouse
Molina-Ortiz P, Polizzi S, Ramery E, Gayral S, Delierneux C, Oury C, Iwashita S, Schurmans S Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet. PLoS Genet, 2014-06-26;10(6):e1004420. 2014-06-26 [PMID: 24967784] (Mouse)		Mouse
Cheng S, Xing W, Pourteymoor S, Mohan S Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development. J Bone Miner Res, 2014-10-01;29(10):2276-86. 2014-10-01 [PMID: 24753072] (Mouse)		Mouse
Hoppe G, Lee T, Yoon S, Yu M, Peachey N, Rayborn M, Zutel M, Trichonas G, Au J, Sears J Inducing a visceral organ to protect a peripheral capillary bed: stabilizing hepatic HIF-1alpha prevents oxygen-induced retinopathy. Am J Pathol, 2014-04-13;184(6):1890-9. 2014-04-13 [PMID: 24731446] (Mouse)		Mouse
Nai A, Pellegrino R, Rausa M, Pagani A, Boero M, Silvestri L, Saglio G, Roetto A, Camaschella C The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice. Haematologica, 2014-03-21;99(6):1016-21. 2014-03-21 [PMID: 24658816] (Mouse)		Mouse
Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil J, Arlet J, Cote F, Courtois G, Ginzburg Y, Daniel T, Chopra R, Sung V, Hermine O, Moura I An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia. Nat Med, 2014-03-23;20(4):398-407. 2014-03-23 [PMID: 24658077] (Mouse)		Mouse
Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, Raymon H, Heise C, Daniel T, Chopra R, Sung V An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol, 2014-03-18;165(6):870-82. 2014-03-18 [PMID: 24635723] (Mouse)		Mouse
Fukumoto R, Burns T, Kiang J Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma. PLoS ONE, 2014-02-28;9(2):e90448. 2014-02-28 [PMID: 24587369] (Mouse)		Mouse
Coe , Lindsay, Madathil , Sangeeth, Casu , Carla, Lanske , Beate, Rivella , Stefano, Sitara , Despina FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis. J Biol Chem, 2014-02-07;289(14):9795-810. 2014-02-07 [PMID: 24509850] (Mouse)		Mouse
Grover , Amit, Mancini , Elena, Moore , Susan, Mead , Adam J, Atkinson , Deborah, Rasmussen , Kasper D, O'Carroll , Donal, Jacobsen , Sten Eir, Nerlov , Claus Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. J Exp Med, 2014-02-03;211(2):181-8. 2014-02-03 [PMID: 24493804] (Mouse)		Mouse
Vadakke Madathil S, Coe L, Casu C, Sitara D Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis. Am J Pathol, 2014-01-08;184(3):827-41. 2014-01-08 [PMID: 24412515] (Mouse)		Mouse
Vignjevic S, Budec M, Markovic D, Dikic D, Mitrovic O, Mojsilovic S, Duric S, Koko V, Cokic B, Cokic V, Jovcic G Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. J Cell Mol Med, 2013-11-27;18(1):91-103. 2013-11-27 [PMID: 24283209] (Mouse)		Mouse
Arsenault , Patrick, Pei , Fei, Lee , Rebecca, Kerestes , Heddy, Percy , Melanie, Keith , Brian, Simon , M Celest, Lappin , Terence, Khurana , Tejvir S, Lee , Frank S A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem, 2013-10-11;288(47):33571-84. 2013-10-11 [PMID: 24121508] (Mouse)		Mouse
Ferreira R, Spensberger D, Silber Y, Dimond A, Li J, Green A, Gottgens B Impaired in vitro erythropoiesis following deletion of the Scl (Tal1) +40 enhancer is largely compensated for in vivo despite a significant reduction in expression. Mol Cell Biol, 2013-01-14;33(6):1254-66. 2013-01-14 [PMID: 23319051] (Mouse)		Mouse
Peslak , Scott A, Wenger , Jesse, Bemis , Jeffrey, Kingsley , Paul D, Koniski , Anne D, McGrath , Kathleen, Palis , James EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress. Blood, 2012-08-13;120(12):2501-11. 2012-08-13 [PMID: 22889760] (Mouse)		Mouse
Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea. BMC Neurosci, 2012-07-03;13(0):77. 2012-07-03 [PMID: 22759774] (Mouse)		Mouse
Querbes , William, Bogorad , Roman L, Moslehi , Javid, Wong , Jamie, Chan , Amy Y, Bulgakova , Elena, Kuchimanchi , Satya, Akinc , Akin, Fitzgerald , Kevin, Koteliansky , Victor, Kaelin , William Treatment of erythropoietin deficiency in mice with systemically administered siRNA. Blood, 2012-05-18;120(9):1916-22. 2012-05-18 [PMID: 22611156] (Mouse)		Mouse
Tanaka T, Kai S, Koyama T, Daijo H, Adachi T, Fukuda K, Hirota K General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain. PLoS ONE, 2011-12-27;6(12):e29378. 2011-12-27 [PMID: 22216265] (Mouse)		Mouse
Talbot AL, Bullock GC, Delehanty LL Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling. PLoS ONE, 2011-08-22;6(8):e23850. 2011-08-22 [PMID: 21887333] (Mouse)		Mouse
Ikeda K, Mason PJ, Bessler M 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice. Blood, 2011-04-01;117(22):5860-9. 2011-04-01 [PMID: 21460244] (Mouse)		Mouse
Salojin KV, Cabrera RM, Sun W A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood, 2011-02-23;117(18):4895-904. 2011-02-23 [PMID: 21346251] (Mouse)		Mouse
Hegde NV, Jensen GL, Unger EL A postweaning iron-adequate diet following neonatal iron deficiency affects iron homeostasis and growth in young rats. J. Nutr., 2011-01-05;141(3):386-90. 2011-01-05 [PMID: 21209256] (Rat)		Rat
Jackson A, Nanton MR, O'Donnell H Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly. J. Immunol., 2010-10-15;185(10):6198-204. 2010-10-15 [PMID: 20952675] (Mouse)		Mouse
Kosovac D, Wild J, Ludwig C, Meissner S, Bauer AP, Wagner R Minimal doses of a sequence-optimized transgene mediate high-level and long-term EPO expression in vivo: challenging CpG-free gene design. Gene Ther., 2010-10-14;18(2):189-98. 2010-10-14 [PMID: 20944679] (Mouse)		Mouse
Li J, Spensberger D, Ahn JS JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood, 2010-05-20;116(9):1528-38. 2010-05-20 [PMID: 20489053] (Mouse)		Mouse
Ramadori P, Ahmad G, Ramadori G Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acute-phase response: a role for IL-6. Lab. Invest., 2010-05-10;90(9):1306-24. 2010-05-10 [PMID: 20458283] (Mouse)		Mouse
Gothelf A, Hojman P, Gehl J Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice. Gene Ther., 2010-04-22;17(9):1077-84. 2010-04-22 [PMID: 20410932] (Mouse)		Mouse
Wang S, Dale GL, Song P AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J. Biol. Chem., 2010-04-14;285(26):19976-85. 2010-04-14 [PMID: 20392689] (Mouse)		Mouse
Morrison LJ, McLellan S, Sweeney L, Chan CN, MacLeod A, Tait A, Turner CM Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection. Infect. Immun., 2010-01-19;78(3):1096-108. 2010-01-19 [PMID: 20086091] (Mouse)		Mouse
Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J. Clin. Invest., 2009-10-05;119(11):3373-83. 2009-10-05 [PMID: 19809162] (Mouse)		Mouse
Meza NW, Alonso-Ferrero ME, Navarro S, Quintana-Bustamante O, Valeri A, Garcia-Gomez M, Bueren JA, Bautista JM, Segovia JC Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. Mol. Ther., 2009-09-15;17(12):2000-9. 2009-09-15 [PMID: 19755962] (Mouse)		Mouse
Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-09-04;297(6):L1160-9. 2009-09-04 [PMID: 19734318] (Mouse)		Mouse
Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain. Brain Res., 2009-05-18;1280(0):43-51. 2009-05-18 [PMID: 19450570] (Mouse)		Mouse
Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J. Clin. Invest., 2009-04-06;119(5):1159-66. 2009-04-06 [PMID: 19352007] (Mouse)		Mouse
Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood, 2008-08-11;112(9):3878-88. 2008-08-11 [PMID: 18694996] (Mouse)		Mouse
Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell, 2008-04-18;133(2):223-34. 2008-04-18 [PMID: 18423195] (Mouse)		Mouse
Xing S, Wanting TH, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood, 2008-03-11;111(10):5109-17. 2008-03-11 [PMID: 18334677] (Mouse)		Mouse
Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood, 2007-12-26;111(8):3931-40. 2007-12-26 [PMID: 18160670] (Mouse)		Mouse
Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. Biochem. J., 2008-04-01;411(1):97-105. 2008-04-01 [PMID: 18047470] (Mouse)		Mouse
Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest., 2007-12-01;117(12):3879-3889. 2007-12-01 [PMID: 17992257] (Mouse)		Mouse
Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation. Exp. Cell Res., 2007-09-20;313(20):4120-9. 2007-09-20 [PMID: 17950726] (Mouse)		Mouse
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)		Mouse
Geny B, Khun H, Fitting C, Zarantonelli L, Mazuet C, Cayet N, Szatanik M, Prevost MC, Cavaillon JM, Huerre M, Popoff MR Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability. Am. J. Pathol., 2007-03-01;170(3):1003-17. 2007-03-01 [PMID: 17322384] (Mouse)		Mouse
Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S Suppression of hepcidin during anemia requires erythropoietic activity. Blood, 2006-08-01;108(12):3730-5. 2006-08-01 [PMID: 16882706] (Mouse)		Mouse
Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006-05-23;108(6):2041-4. 2006-05-23 [PMID: 16720837] (Mouse)		Mouse
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