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Glut4 Antibody - BSA Free

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Western Blot: Glut4 Antibody [NBP1-49533] - Glycolysis-related genes and proteins were upregulated in differentiated podocytes. Representative blot images of glycolysis-related proteins (n =3). d All proteins were ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, PlSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml
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Glut4 Antibody - BSA Free Summary

Immunogen
A synthetic peptide from the human Glucose Transporter GLUT4 protein [UniProt P14672]
Localization
Endomembrane system; Multi-pass membrane protein. Cytoplasm - perinuclear region. Note: Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC2A4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Flow (Intracellular)
  • Flow Cytometry reported by customer review
  • Immunocytochemistry/ Immunofluorescence 1:100
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin reported in scientific literature (PMID 24339864)
  • Knockdown Validated reported in scientific literature (PMID 31555030)
  • Western Blot 0.5ug/ml
Control
MCF-7 Whole Cell Lysate
Control Peptide
Glut4 Peptide (NBP1-49533PEP)
Reviewed Applications
Read 4 Reviews rated 4
using
NBP1-49533 in the following applications:

Publications
Read Publications using
NBP1-49533 in the following applications:

Reactivity Notes

Plant reactivity reported in scientific literature (PMID: 31555030).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Glut4 Antibody - BSA Free

  • Glut4
  • GLUT-4
  • GLUT4Glucose transporter type 4, insulin-responsive
  • insulin-responsive glucose transporter type 4
  • SLC2A4
  • solute carrier family 2 (facilitated glucose transporter), member 4
  • solute carrier family 2, facilitated glucose transporter member 4

Background

Glucose Transporter GLUT4 (SLC2A4 or GLUT4) is an insulin-sensitive glucose transporter which facilitate insulin-stimulated glucose uptake in adipose tissue, skeletal muscle and cardiac tissues (that specifically express GLUT4). GLUT4 is a 12-transmembrane domain/ multi-pass membrane protein localized in endomembrane system as well as cytoplasm near perinuclear region, and facilitates glucose transport in the direction of glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation via TBC1D4 phosphorylation. Transgenic mice lacking or overexpressing GLUT4 respectively decrease or increase whole-body insulin sensitivity, suggesting its role in maintenance of glucose homeostasis, and accordingly, under obesity conditions, reduction of GLUT4 gene expression is directly related to insulin resistance development. Inflammatory cytokines produced by the adipose tissue including TNF-alpha, IL-6 etc have been related to reduce GLUT4 expression and defective GLUT4 is an underlying cause of NIDDM.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Recent Reviews

4
5
1
4
2
3
1
2
0
1
0

Verified Customer
04/23/2019
Application: WB
Species: Mouse

Verified Customer
03/27/2018
Application: WB
Species: Mouse

Frances Bell
03/28/2017
Application: WB
Species: Mouse

Bioinformatics

Gene Symbol SLC2A4
Entrez
Uniprot