IRS1 Antibody

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Porcine.

We have publications tested in 3 applications: IHC, Simple Western, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-82001	Applications	Species
Aamir K, Sethi G, Afrin MR et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats Life sciences 2023-08-15 [PMID: 37307966] (Simple Western, IHC, Rat)	Simple Western, IHC	Rat
Fernandez-de Frutos M, Galan-Chilet I, Goedeke L et al. MiR-7 impairs insulin signaling and regulates A beta levels through posttranscriptional regulation of the IRS-2, INSR, IDE and LXR pathway Mol. Cell. Biol. [PMID: 31501273]
Ratai, O;Hermainski, J;Ravichandran, K;Pongs, O; NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice Front Mol Neurosci 2019-04-03 [PMID: 31001084] (WB, Mouse)	WB	Mouse
Dickson MJ, Hager CL, Al-Shaibi A et al. Impact of heat stress during the follicular phase on porcine ovarian steroidogenic and phosphatidylinositol-3 signaling. J Anim Sci 2018-06-04 [PMID: 29684161] (Porcine)		Porcine

Array NB100-82001

• IRS1 Antibodies
• IRS1 ELISA Kits
• IRS1 Proteins