Will you please recommend me antibodies to insulin, the most suitable for immunohistochemistry in the pancreas of guinea pigs? Desirable to be conjugated with some pigment and there was no need for secondary antibodies.

Name: Insulin Antibody (182410) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB1417
Price: 479 USD

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Accepted Answer

I have carried out a search and the best antibody I recommend is  NB600-1488. This is a primary unconjugated antibody however and you will need a secondary. If you click on the product link and then click on related products, a list of all recommended secondary antibodies will appear.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, BvSpecies Glossary
Applications	IHC, CyTOF-ready, Flow, ICC/IF
Clone	182410
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB1417U

Alexa Fluor 350 IC1417U-100UG

Alexa Fluor 405 IC1417V-100UG

Alexa Fluor 405 FAB1417V

Alexa Fluor 488 IC1417G-100UG

Alexa Fluor 488 FAB1417G

Alexa Fluor 532 FAB1417X

Alexa Fluor 594 IC1417T-100UG

Alexa Fluor 594 FAB1417T

Alexa Fluor 647 IC1417R-100UG

Alexa Fluor 647 FAB1417R

Alexa Fluor 700 FAB1417N

Alexa Fluor 700 IC1417N-100UG

Alexa Fluor 750 FAB1417S

Alexa Fluor 750 IC1417S-100UG

Allophycocyanin IC1417A

Allophycocyanin FAB1417A

Biotin FAB1417B

DyLight 350 FAB1417D

DyLight 405 FAB1417E

DyLight 488 FAB1417K

DyLight 550 FAB1417L

DyLight 594 FAB1417M

DyLight 650 FAB1417W

DyLight 680 FAB1417Y

DyLight 755 FAB1417Z

FITC FAB1417F

HRP FAB1417H

Janelia Fluor 549 FAB1417I

Janelia Fluor 646 FAB1417J

PE FAB1417P

PerCP FAB1417C

mFluor Violet 450 SE FAB1417MFV450

mFluor Violet 500 SE FAB1417MFV500

mFluor Violet 610 SE FAB1417MFV610

Catalog# & Formulation	Size	Price
Carrier Free IC1417A

Carrier Free MAB1417-SP

Carrier Free IC1417V-100UG

Carrier Free IC1417U-100UG

Carrier Free IC1417T-100UG

Carrier Free IC1417S-100UG

Carrier Free IC1417R-100UG

Carrier Free IC1417N-100UG

Carrier Free IC1417G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB1417U
Alexa Fluor 350	IC1417U-100UG
Alexa Fluor 405	IC1417V-100UG
Alexa Fluor 405	FAB1417V
Alexa Fluor 488	IC1417G-100UG
Alexa Fluor 488	FAB1417G
Alexa Fluor 532	FAB1417X
Alexa Fluor 594	IC1417T-100UG
Alexa Fluor 594	FAB1417T
Alexa Fluor 647	IC1417R-100UG
Alexa Fluor 647	FAB1417R
Alexa Fluor 700	FAB1417N
Alexa Fluor 700	IC1417N-100UG
Alexa Fluor 750	FAB1417S
Alexa Fluor 750	IC1417S-100UG
Allophycocyanin	IC1417A
Allophycocyanin	FAB1417A
Biotin	FAB1417B
DyLight 350	FAB1417D
DyLight 405	FAB1417E
DyLight 488	FAB1417K
DyLight 550	FAB1417L
DyLight 594	FAB1417M
DyLight 650	FAB1417W
DyLight 680	FAB1417Y
DyLight 755	FAB1417Z
FITC	FAB1417F
HRP	FAB1417H
Janelia Fluor 549	FAB1417I
Janelia Fluor 646	FAB1417J
PE	FAB1417P
PerCP	FAB1417C
mFluor Violet 450 SE	FAB1417MFV450
mFluor Violet 500 SE	FAB1417MFV500
mFluor Violet 610 SE	FAB1417MFV610

Insulin Antibody (182410) [Unconjugated]

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Publications for Insulin Antibody (MAB1417)(24)

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Immunogen	E. coli-derived recombinant human Insulin
Specificity	Detects bovine, human, and mouse insulin.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Rat
Gene	INS
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB1417	Applications	Species
Terry, TT;Gigante, ED;Alexandre, CM;Brewer, KM;Engle, SE;Yue, X;Berbari, NF;Vaisse, C;Caspary, T; Ciliary ARL13B prevents obesity in mice bioRxiv : the preprint server for biology 2023-08-04 [PMID: 37577625] (IHC, Mouse)	IHC	Mouse
Y Wakabayash, T Miyatsuka, M Miura, M Himuro, T Taguchi, H Iida, Y Nishida, Y Fujitani, H Watada STAT3 suppression and beta-cell ablation enhance alpha-to-beta reprogramming mediated by Pdx1 Scientific Reports, 2022-12-10;12(1):21419. 2022-12-10 [PMID: 36496541] (IHC, Mouse)	IHC	Mouse
M. Jimenez-Gonzalez, R. Li, L. E. Pomeranz, A. Alvarsson, R. Marongiu, R. F. Hampton et al. Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism Nature Biomedical Engineering 7/14/2022 [PMID: 35835995]
Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li et al. IL18 signaling causes islet beta cell development and insulin secretion via different receptors on acinar and beta cells Developmental Cell 6/6/2022 [PMID: 35675813]
L Lei, Y Huan, Q Liu, C Li, H Cao, W Ji, X Gao, Y Fu, P Li, R Zhang, Z Abliz, Y Liu, S Liu, Z Shen Morus alba L. (Sangzhi) Alkaloids Promote Insulin Secretion, Restore Diabetic beta-Cell Function by Preventing Dedifferentiation and Apoptosis Frontiers in Pharmacology, 2022-03-03;13(0):841981. 2022-03-03 [PMID: 35308210] (IHC, Mouse)	IHC	Mouse
MR Brown, SK Sen, A Mazzone, TK Her, Y Xiong, JH Lee, N Javeed, CS Colwell, K Rakshit, NK LeBrasseur, A Gaspar-Mai, T Ordog, AV Matveyenko Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of beta cell function Science Advances, 2021-12-15;7(51):eabg6856. 2021-12-15 [PMID: 34910509] (ICC, Mouse)	ICC	Mouse
J Rui, S Deng, AL Perdigoto, G Ponath, R Kursawe, N Lawlor, T Sumida, M Levine-Rit, ML Stitzel, D Pitt, J Lu, KC Herold Tet2 Controls the Responses of beta cells to Inflammation in Autoimmune Diabetes Nature Communications, 2021-08-20;12(1):5074. 2021-08-20 [PMID: 34417463] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Sharon Lee, Jing Zhang, Supraja Saravanakumar, Marcus F. Flisher, David R. Grimm, Talitha van der Meulen et al. Virgin beta -Cells at the Neogenic Niche Proliferate Normally and Mature Slowly Diabetes 5/1/2021 [PMID: 33563657]
Hui Cao, Caina Li, Lei Lei, Xing Wang, Shuainan Liu, Quan Liu et al. Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice Frontiers in Pharmacology 10/22/2020 [PMID: 33192521]
M Kojima, H Takahashi, T Kuwashiro, K Tanaka, H Mori, I Ozaki, Y Kitajima, Y Matsuda, K Ashida, Y Eguchi, K Anzai Glucagon-Like Peptide-1 Receptor Agonist Prevented the Progression of Hepatocellular Carcinoma in a Mouse Model of Nonalcoholic Steatohepatitis Int J Mol Sci, 2020-08-10;21(16):. 2020-08-10 [PMID: 32785012] (IHC, Mouse)	IHC	Mouse
DM Elizondo, NZD Brandy, RLL da Silva, TR de Moura, J Ali, D Yang, MW Lipscomb Pancreatic islets seeded in a novel bioscaffold forms an organoid to rescue insulin production and reverse hyperglycemia in models of type 1 diabetes Sci Rep, 2020-03-09;10(1):4362. 2020-03-09 [PMID: 32152396] (IHC, Mouse)	IHC	Mouse
DG Alleva, M Rezaee, L Yip, G Ren, J Rosenberg, W Concepcion, A Escher, S Shabahang, AS Thakor Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapyï¿½ (ADiï¿½), ADi-100 Biomedicines, 2020-03-04;8(3):. 2020-03-04 [PMID: 32143316] (IHC-P, Mouse)	IHC-P	Mouse
FC Ning, N Jensen, J Mi, W Lindström, M Balan, L Muhl, U Eriksson, I Nilsson, D Nyqvist VEGF-B ablation in pancreatic beta-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake Sci Rep, 2020-01-22;10(1):923. 2020-01-22 [PMID: 31969592] (IHC, Mouse)	IHC	Mouse
Luca De Toni, Diego Guidolin, Vincenzo De Filippis, Daniele Peterle, Maria Santa Rocca, Andrea Di Nisio et al. SHBG141–161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and beta -Langerhans cell lines Scientific Reports 12/19/2019 [PMID: 31857654]
Z Fang, C Weng, H Li, R Tao, W Mai, X Liu, L Lu, S Lai, Q Duan, C Alvarez, P Arvan, A Wynshaw-Bo, Y Li, Y Pei, F Jin, Y Li Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key ?-Cell-Specific Disease Genes Cell Rep, 2019-03-12;26(11):3132-3144.e7. 2019-03-12 [PMID: 30865899] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström et al. The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass EJNMMI Research 12/27/2018 [PMID: 30588560]
Danielle J. Borg, Felicia Y. T. Yap, Sahar Keshvari, David G. Simmons, Linda A. Gallo, Amelia K. Fotheringham et al. Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction Islets 1/2/2018 [PMID: 29157116]
M. Bahrebar, M. Soleimani, M. H. Karimi, A. Vahdati, R. Yaghobi Generation of Islet-like Cell Aggregates from Human Adipose Tissue-derived Stem Cells by Lentiviral Overexpression of PDX-1 Int J Organ Transplant Med 6/18/2015 [PMID: 26082830]
Cucak H, Mayer C, Tonnesen M, Thomsen L, Grunnet L, Rosendahl A Macrophage contact dependent and independent TLR4 mechanisms induce beta-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. PLoS ONE, 2014-03-03;9(3):e90685. 2014-03-03 [PMID: 24594974] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Cucak H, Grunnet L, Rosendahl A Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. J Leukoc Biol, 2013-09-05;95(1):149-60. 2013-09-05 [PMID: 24009176] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Hagberg C, Mehlem A, Falkevall A, Muhl L, Fam B, Ortsater H, Scotney P, Nyqvist D, Samen E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjoholm A, Nash A, Eriksson U Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature, 2012-09-26;490(7420):426-30. 2012-09-26 [PMID: 23023133] (IHC-P, Mouse)	IHC-P	Mouse
Kalis M, Bolmeson C, Esguerra JL, Gupta S, Edlund A, Tormo-Badia N, Speidel D, Holmberg D, Mayans S, Khoo NK, Wendt A, Eliasson L, Cilio CM Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS ONE, 2011-12-27;6(12):e29166. 2011-12-27 [PMID: 22216196] (ICC, Mouse)	ICC	Mouse
Jin CX, Li WL, Xu F, Geng ZH, He ZY, Su J, Tao XR, Ding XY, Wang X, Hu YP Conversion of immortal liver progenitor cells into pancreatic endocrine progenitor cells by persistent expression of Pdx-1. J. Cell. Biochem., 2008-05-01;104(1):224-36. 2008-05-01 [PMID: 17979180] (ICC, IHC-Fr, Mouse)	ICC, IHC-Fr	Mouse
Dowling P, O&apos;Driscoll L, O&apos;Sullivan F, Dowd A, Henry M, Jeppesen PB, Meleady P, Clynes M Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress. Proteomics, 2006-12-01;6(24):6578-87. 2006-12-01 [PMID: 17163442] (ICC, Mouse)	ICC	Mouse
Show All 24 Publications. Collapse Publications.