XRCC3 Antibody - BSA Free

XRCC3 (X-ray repair cross-complementing group 3) belongs to RecA family and participates in HRR/homologous recombination repair pathway which is an "error free" DNA repair mechanism that utilizes information encoded by homologous sequence to repair double-strand breaks (DSBs), chromosomal fragmentation, translocations and deletions. XRCC3 is required for Rad51 assembly/stabilization and in HRR pathway, XRCC3 protein interacts with Rad51 protein for contributing to chromosome integrity maintainance, thereby preventing mutations which can lead to carcinogenesis. In addition to repairing DSBs, XRCC3 also plays a role repairing wide range of DNA damage arising from carcinogens. Moreover, XRCC3 can control mtDNA copy number under conditions of oxidative stress in the presence of RAD51 as well as RAD51C. It forms a part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, and has been suggested to forms complex with FANCD2, BRCA2 and phosphorylated FANCG. XRCC3 also interacts with SWSAP1 and ZSWIM7 for executing homologous recombination repair and defective XRCC3 have been linked to susceptibility to breast cancer as well as cutaneous malignant melanoma type 6 (CMM6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Drosophila, Hamster.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using NB100-165	Applications	Species
Girard PM, Francesconi S, Pozzebon M et al. UVA-induced damage to DNA and proteins: direct versus indirect photochemical processes. J. Phys.: Conf. Ser. 2011-01-01
Longo MA, Roy S, Chen Y et al. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles Nature communications 2023-07-24 [PMID: 37488098] (WB, IP)	WB, IP
Shafi AA, McNair CM, McCann JJ, et al. The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair Nature communications 2021-01-15 [PMID: 33452241] (WB, Human)	WB	Human
Pae J, Cinalli RM, Marzio A et al. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK Dev. Cell 2017-07-24 [PMID: 28743001] (Drosophila)		Drosophila
Ermilov A, Kumari A, Li L Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling PLoS Genet, 2016-11-28;12(11):e1006442. 2016-11-28 [PMID: 27893742]
Parplys AC, Zhao W, Sharma N et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015-08-31 [PMID: 26323318] (WB, Human)	WB	Human
Kumari A, Ermilov An, Allen Bl et al. Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation. J. neurophysiol. 2014-11-12 [PMID: 25392175]
Sterle I, Zupancic D, Romih R. Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder. Biomed Res Int. 2014-05-28 [PMID: 24868547]
Park JY, Singh TR, Nassar N et al. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene. 2013-10-21 [PMID: 24141787] (WB, Human)	WB	Human
Girard PM, Graindorge D, Smirnova V et al. Oxidative Stress in Mammalian Cells Impinges on the Cysteines Redox State of Human XRCC3 Protein and on Its Cellular Localization. PLoS One. 2013-10-08 [PMID: 24116071] (WB, Hamster)	WB	Hamster
Huang JW, Wang Y, Dhillon KK et al. Systematic Screen Identifies miRNAs That Target RAD51 and RAD51D to Enhance Chemosensitivity. Mol Cancer Res 2013-12-01 [PMID: 24088786] (WB, Human)	WB	Human
Nicolay NH, Carter R, Hatch SB et al. Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta Carcinogenesis 2012-09-03 [PMID: 22822095] (WB, Human)	WB	Human
Al-Minawi AZ, Lee Y-F, Hakansson D et al. The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-str cross-links. Nucleic Acids Res:gkp705. 2009-01-01 [PMID: 19713438]
Katsura M, Tsuruga T, Date O et al. The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Nucleic Acids Res;37(12):3959-3968. 2009-01-01 [PMID: 19403737]
Compton, SA et al. Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Cancer Res;67(4):1513-9. 2007-02-15 [PMID: 17308089]
Nagaraju, G et al. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol;26(21):8075-86. 2006-11-01 [PMID: 16954385] (WB, Human)	WB	Human
Szuts, D et al. Role for RAD18 in homologous recombination in DT40 cells. Mol Cell Biol;26(21):8032-41. 2006-11-01 [PMID: 16923963] (WB, Human)	WB	Human
Yoshihara T, Ishida M, Kinomura A et al. XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. EMBO J 2004-02-01 [PMID: 14749735] (IP, Human)	IP	Human
Show All 18 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	01/08/2014	View Summary Application Western Blot Sample Tested Human transformed fibroblasts whole cell extract Species Human

Array NB100-165

• XRCC3 Antibodies
• XRCC3 Lysates
• XRCC3 Proteins