XRCC3 Products

Description

XRCC3, also known as DNA repair protein XRCC3, X-ray repair cross-complementing protein 3, and CMM6, belongs to the RecA family and the RAD51 subfamily. XRCC3 plays a role in the homologous recombination repair (HRR) pathway of double-stranded DNA. The pathway is responsible for repairing chromosomal fragmentation, translocations, and deletions. Additionally, XRCC3 is also involved in regulating the mitochondrial DNA copy number in the presence of oxidative stress in the presence of RAD51 and RAD51C. XRCC3 is a functional compliment to Chinese hamster irs1SF. Rare microsatellite polymorphisms in the XRCC3 gene have been associated with cancer in patients with radiosensitivity. Defects of the XRCC3 gene have also been linked to breast cancer and cutaneous malignant melanoma type 6 (CMM6).

Bioinformatics

Entrez	314463 Rat 74335 Mouse 7517 Human
Uniprot	AAH01036.1 Human AAH11725 Human NM_005432 Human NP_001093588 Human NP_001093589 Human NP_005423.1 Human O43542 Human
Product By Gene ID	7517
Alternate Names	CMM6 DNA repair protein XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 X-ray repair cross-complementing protein 3

Research Areas for XRCC3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chemokine Research
DNA Repair
Genes Sensitive to DNA Damaging Agents
Homologous Recombination
Tumor Suppressors