ATM Antibody (2C1)

ATM (ataxia telangiectasia mutated kinase) is the master regulator of the DNA double-strand break (DSB) repair pathway. This ubiquitously expressed serine/threonine protein kinase belongs to the PI3K-like family of proteins and responds to DSBs caused by oxidative and other genotoxic stresses (1). In addition to regulating the DNA damage response, ATM participates in vesicle and protein transport, T-cell development, gonads/neurological function, pre-B cell allelic exclusion, cell cycle control, and acts as a tumor suppressor (2,3). Defects in ATM are associated with ataxia telangiectasia (AT), T-cell acute lymphoblastic leukemia (TALL), T-prolymphocytic leukemia (TPLL), and B-cell non-Hodgkin lymphomas (BNHL) including mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia (BCLL) (4).

The theoretical molecular weight of ATM is 350 kDa and it has 3 main domains: a FAT (focal adhesion targeting) domain (aa 1960-2566), a PI-3/PI-4 kinase catalytic domain (aa 2712-2962), and a C-terminal FAT domain (aa 3024-3056). ATM exists as a dimer or tetramer in its inactive state. Upon sensing DNA damage, the MRE11-RAD50-NBS1 (MRN) complex recruits ATM. The intricate process of ATM activation involves acetylation by KAT5/TIP60, autophosphorylation at Ser-1981, and dissociation into catalytically active monomers (5). Following activation, ATM phosphorylates multiple substrates such as p53/TP53 and Chk2 involved in DNA repair, checkpoint signaling, and the apoptosis pathway.

References

1. Paull TT. (2015) Mechanisms of ATM Activation. Annu Rev Biochem. 84:711-38. PMID: 25580527

2. Chaudhary MW and Al-Baradie RS. (2014) Ataxia-telangiectasia: future prospects. Appl Clin Genet. 7:159-167. PMID: 25258552

3. Stagni V, Cirotti C, and Barila D. (2018) Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra. Front Oncol. 8:73. PMID: 29616191

4. Gumy-Pause F, Wacker P, and Sappino AP. (2004) ATM gene and lymphoid malignancies. Leukemia. 18(2):238-42. PMID: 14628072

5. Adamowicz M. (2018) Breaking up with ATM. J Immunol Sci. 2(1):26-31. PMID: 29652413

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Chinese Hamster.

We have publications tested in 9 applications: Block/Neutralize, ELISA, FLOW, ICC/IF, IHC-P, IP, SDS-Page, WB, Western Blot.

Showing Publications 1 - 10 of 131. Show All 131 Publications. Collapse Publications.

Publications using NB100-309	Applications	Species
Maeda J, Haskins JS, Kato TA XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency Mutation research 2023-02-13 [PMID: 36812659] (WB, Chinese Hamster)	WB	Chinese Hamster
Osma-Garcia IC, Capitan-Sobrino D, Mouysset M et al. The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis Cell reports 2022-12-20 [PMID: 36543128] (FLOW, Mouse)	FLOW	Mouse
Osma-Garcia IC, Capitan-Sobrino D, Mouysset M et al. The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis Cell reports 2022-12-20 [PMID: 36543128] (FLOW, Mouse)	FLOW	Mouse
Cui WW, Ye C, Wang KX et al. Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction Frontiers in Cardiovascular Medicine 2022-04-18 [PMID: 35509278] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Yang Y, Lu H, Chen C et al. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia Nature communications 2022-01-14 [PMID: 35031618] (WB)	WB
Wang S, Luke CJ, Pak SC et al. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation Communications Biology 2022-01-12 [PMID: 35022555] (Block/Neutralize)	Block/Neutralize
Fu X, Duan Z, Lu X et al. SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response Cancer biotherapy & radiopharmaceuticals 2022-03-10 [PMID: 35271349] (WB, Human)	WB	Human
Kirtay M, Sell J, Marx C Et Al. ATR regulates neuronal activity by modulating presynaptic firing Nature communications 2021-07-01 [PMID: 34210973] (WB, SDS-Page)	WB, SDS-Page
Blakemore D, Vilaplana-Lopera N, Almaghrabi R et al. MYBL2 and ATM suppress replication stress in pluripotent stem cells EMBO reports 2021-03-28 [PMID: 33779025] (WB, Mouse)	WB	Mouse
T Affandi, AM Ohm, D Gaillard, A Haas, ME Reyland Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair The Journal of Biological Chemistry, 2021-02-09;0(0):100401. 2021-02-09 [PMID: 33571522]
Bensimon A, Koch J P et al. Deciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics. Mol Oncol 2020-01-06 [PMID: 32336009] (WB, Human)	WB	Human
El Hajjar J, Chatoo W, Hanna R, Nkanza P. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1 +/- mice Sci Rep 2019-01-26 [PMID: 30679733]
Beluzic L, Grbesa I, Beluzic R et al. Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest. Sci Rep 2018-09-18 [PMID: 30228286] (WB, Human)	WB	Human
Goder A, Emmerich C, Nikolova T, Kiweler N. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun. 2018-02-22 [PMID: 29472538] (WB)	WB
Fu X, Zhang C, Meng H, Zhang K. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018-02-19 [PMID: 29459768] (WB)	WB
Park SJ, Kong HK, Kim YS et al. Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest. Am J Cancer Res 2015-01-01 [PMID: 26328244] (WB)	WB
Muraki K, Han L, Miller D, Murnane JP et al. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks Nucleic Acids Res. 2015-07-23 [PMID: 26209132] (WB, Human)	WB	Human
Simoes M, Martins C, Ferreira F et al. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus Virus Res. 2015-07-13 [PMID: 26183880]
Vermezovic J, Adamowicz M, Santarpia L et al. Notch is a direct negative regulator of the DNA-damage response Nat. Struct. Mol. Biol. 2015-04-20 [PMID: 25895060] (IHC-P, WB, Human)	IHC-P, WB	Human
Batenburg NL, Thompson EL, Hendrickson EA, Zhu XD. Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J. 2015-03-27 [PMID: 25820262] (WB, Mouse)	WB	Mouse
Palazzo, L, Della Monica, R Et al. ATM controls proper mitotic spindle structure. Cell Cycle 2014-02-21 [PMID: 24553124] (WB, Human)	WB	Human
Min W, Bruhn C, Grigaravicius et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun 2013-12-20 [PMID: 24356582] (WB, Mouse)	WB	Mouse
Simoes M, Martins C, Ferreira F. Host DNA Damage Response facilitates African Swine Fever Virus infection. Vet Microbiol 2013-01-23 [PMID: 23398667]
Gutierrez-Gonzalez A, Belda-Iniesta C, Bargiela-Iparraguirre J et al. Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair Apoptosis 2012-12-28 [PMID: 23271172] (WB, Human)	WB	Human
Shi Y, Felley-Bosco E, Marti TM et al. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer 2012-12-01 [PMID: 23211021] (WB, Human)	WB	Human
Murad NA, Cullen JK, McKenzie M et al. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion 2012-11-01 [PMID: 23178371] (WB, Human)	WB	Human
Sakasai R, Sakai A, Iimori M et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells 2012-12-01 [PMID: 23157317] (WB, Human)	WB	Human
Shi Y, Felley-Bosco E, Marti TM et al. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS One 2012-01-01 [PMID: 23028957] (WB, Human)	WB	Human
Baritaud M, Cabon L, Delavallee L et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-Pk-induced histone H2AX Ser139 phosphorylation. Cell Death Dis 2012-09-01 [PMID: 22972376] (WB)	WB
Hardee ME, Marciscano AE, Medina-Ramirez CM et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-B. Cancer Res 2012-08-01 [PMID: 22693253] (WB, Human)	WB	Human
Mahajan K, Coppola D, Rawal B et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem 2012-06-01 [PMID: 22566699] (WB, Human)	WB	Human
Hsu CC, Lee YC, Yeh SH et al. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem 2012-06-01 [PMID: 22563078] (WB, Human)	WB	Human
Dellago H, Khan A, Nussbacher M et al. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging (Albany NY) 2012-04-01 [PMID: 22529335]
Yan Y, Greer PM, Cao PT, Kolb RH, Cowan KH. RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation. Breast Cancer Res;14(2):R60. 2012-04-11 [PMID: 22494620] (WB, Human)	WB	Human
Ai L, Skehan RR, Saydi J et al. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor k light chain enhancer of activated B cells (NFkB) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem 2012-05-01 [PMID: 22493284] (ELISA, Human)	ELISA	Human
Zhang J, de Toledo SM, Pandey BN et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci USA 2012-04-01 [PMID: 22451927]
Kang MA, So EY, Ouchi T et al. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem 2012-05-01 [PMID: 22431734] (WB)	WB
Hao Z, Duncan GS, Su YW et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med 2012-01-01 [PMID: 22213803]
Xu Y, Parmar K, Du F et al. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol 2011-01-01 [PMID: 22187663] (WB, Human)	WB	Human
Assaily W, Rubinger DA, Wheaton K et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell 2011-11-01 [PMID: 22055193] (WB, Mouse)	WB	Mouse
Sugimoto N, Yugawa T, Iizuka M et al. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem 2011-11-01 [PMID: 21937426]
Brown JA, Roberts TL, Richards R et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol 2011-11-01 [PMID: 21911475] (WB)	WB
Hada M, Huff JL, Patel ZS et al. AT cells are not radiosensitive for simple chromosomal exchanges at low dose. Mutat Res 2011-11-01 [PMID: 21889946] (WB, Human)	WB	Human
Serrano-Tejero D, Bleau A-M, Fernandez-Garcia I et al. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer 910(1):96. 2011-08-01 [PMID: 21827695]
Luo K, Yuan J, Lou Z et al. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem 2011-08-01 [PMID: 21705321] (IP, Human)	IP	Human
Bouquet F, Ousset M, Biard D et al. A DNA-dependent stress response involving DNA-Pk occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci 2011-06-01 [PMID: 21576354] (WB, Human)	WB	Human
Shouse GP, Nobumori Y, Panowicz MJ et al. ATM-mediated phosphorylation activates the tumor-suppressive function of B56Y-PP2A. Oncogene 2011-09-01 [PMID: 21460856] (WB, Human)	WB	Human
Cherubini G, Naim V, Caruso P et al. The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res 2011-07-01 [PMID: 21421559] (WB, Human)	WB	Human
Chen Y, Chen CF, Riley DJ et al. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle 2011-02-01 [PMID: 21301226] (WB, Human)	WB	Human
Matsumoto Y, Miyamoto T, Sakamoto H et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst) 2011-03-01 [PMID: 21227757] (WB, Human)	WB	Human
Urquhart AJ, Gatei M, Richard DJ et al. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr 2011-01-01 [PMID: 21219611] (WB, Human)	WB	Human
Ruiz Z, Mihaylov IS, Cotmore SF et al. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology 2011-02-01 [PMID: 21193212]
Guo Z, Deshpande R, Paull TT et al. ATM activation in the presence of oxidative stress. Cell Cycle 2010-12-01 [PMID: 21150274] (WB)	WB
Kozlov SV, Graham ME, Jakob B et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem 2011-03-01 [PMID: 21149446] (WB, Human)	WB	Human
Powell MD, Manandhar G, Spate L et al. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl 2010-03-01 [PMID: 21137054] (ICC/IF)	ICC/IF
Xu Y, Sun Y, Jiang X et al. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol 2010-10-01 [PMID: 20876283] (WB, Human)	WB	Human
Huang QM, Tomida S, Masuda Y et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res 2010-11-01 [PMID: 20861182] (WB)	WB
Shanware NP, Zhan L, Hutchinson JA et al. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS One 2010-08-01 [PMID: 20730097] (WB, Human)	WB	Human
Lee JH, Choy ML, Ngo L et al. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci USA 2010-08-01 [PMID: 20679231] (WB, Human)	WB	Human
Fang Z, Kozlov S, McKay MJ et al. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr 2010-06-01 [PMID: 20678261] (IP, Human)	IP	Human
Ousset M, Bouquet F, Fallone F et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle 2010-07-01 [PMID: 20676049] (WB, Human)	WB	Human
Storch K, Eke I, Borgmann K et al. Three-dimensional cell growth confers radioresistance by chromatin density modification. Cancer Res 2010-05-01 [PMID: 20442295] (WB, Human)	WB	Human
Bowen C, Gelmann EP. NkX3.1 activates cellular response to DNA damage. Cancer Res 2010-04-01 [PMID: 20395202] (ICC/IF, Human)	ICC/IF	Human
Kongruttanachok N, Phuangphairoj C, Thongnak A et al. Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer 2010-03-01 [PMID: 20356374] (WB, Human)	WB	Human
Sakasai R, Teraoka H, Takagi M et al. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem 2010-05-01 [PMID: 20304914] (WB, Human)	WB	Human
Wilhelm MT, Rufini A, Wetzel MK et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010-03-15 [PMID: 20194434] (WB, Human)	WB	Human
Kodama M, Otsubo C, Hirota T et al. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol 2010-04-01 [PMID: 20123963] (WB, Human)	WB	Human
Hu H, Du L, Nagabayashi G et al. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci USA 2010-01-01 [PMID: 20080624] (ELISA, Human)	ELISA	Human
Yoshida K, Sugimoto N, Iwahori S et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci 2010-01-01 [PMID: 20048340] (WB, Human)	WB	Human
So S, Davis AJ, Chen DJ et al. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol 2009-12-01 [PMID: 20026654] (WB, Human)	WB	Human
Bolderson E, Tomimatsu N, Richard DJ et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res 2010-04-01 [PMID: 20019063] (WB, Human)	WB	Human
Sakasai R, Teraoka H, Tibbetts RS et al. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst) 2010-01-01 [PMID: 19959400] (WB, Human)	WB	Human
Britton S, Frit P, Biard D et al. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res 2009-10-01 [PMID: 19808974] (WB)	WB
Papp LV, Lu J, Bolderson E et al. SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal 2010-04-01 [PMID: 19803747] (WB, Human)	WB	Human
Sun Y, Jiang X, Xu Y et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol 2009-11-01 [PMID: 19783983] (IP, Human)	IP	Human
Sugimoto N, Yoshida K, Tatsumi Y et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci 2009-04-01 [PMID: 19339550] (WB, Human)	WB	Human
Cui B, Johnson SP, Bullock N et al. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol 2009-06-01 [PMID: 19261750] (WB, Human)	WB	Human
Heffernan TP, Kawasumi M, Blasina A et al. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol 2009-07-01 [PMID: 19242509] (WB, Human)	WB	Human
Nahas SA, Butch AW, Du L et al. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem 2009-03-01 [PMID: 19147735] (ELISA, Human)	ELISA	Human
Chou WC, Wang HC, Wong FH et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008-12-03 [PMID: 18971944] (WB, Human)	WB	Human
Hein J, Boichuk S, Wu J et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol 2009-01-01 [PMID: 18922873] (WB, Human)	WB	Human
Meulle A, Salles B, Daviaud D et al. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS One 2008-01-01 [PMID: 18846213]
Martin LJ, Liu Z, Pipino J et al. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex. 2009-06-01 [PMID: 18820287] (WB) Details: WB (mouse cortical neuron cultures), Figs. 3A, 6A.	WB
Ariumi Y, Kuroki M, Dansako H et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol 2008-10-01 [PMID: 18667510] (IP, Human)	IP	Human
Stohr BA, Blackburn EH. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res 2008-07-01 [PMID: 18593932]
Yalcin S, Zhang X, Luciano JP et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem 2008-09-01 [PMID: 18424439]
RiPrimateus SA, Katzenberger RJ, Trinh AT et al. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev 2008-05-01 [PMID: 18408079]
Wei G, DeFeo K, Hayes CS et al. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res 2008-04-01 [PMID: 18381427] (ICC/IF, Mouse)	ICC/IF	Mouse
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem 2008-05-01 [PMID: 18337245]
Sugimoto N, Kitabayashi I, Osano S et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell 2008-03-01 [PMID: 18162579] (WB, Human)	WB	Human
Wood JL, Singh N, Mer G et al. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 2007-11-01 [PMID: 17925396] (WB, Human)	WB	Human
Sun Y, Xu Y, Roy K et al. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol 2007-12-01 [PMID: 17923702] (WB, Human)	WB	Human
Hong X, Lei L, Kunert B et al. Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors. Cancer Res 2007-08-01 [PMID: 17671184] (WB, Human)	WB	Human
Iwahori S, Shirata N, Kawaguchi Y et al. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol 2007-09-01 [PMID: 17609267]
Fernandes ND, Sun Y, Price BD. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem 2007-06-01 [PMID: 17426037] (WB, Human)	WB	Human
Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J 2007-04-01 [PMID: 17380128] (WB, Human)	WB	Human
Stauffer D, Chang B, Huang J et al. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem 2007-03-01 [PMID: 17272271] (WB, Human)	WB	Human
Shi Y, Dodson GE, Mukhopadhyay PS et al. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem 2007-03-01 [PMID: 17244605] (WB, Human)	WB	Human
Geng L, Zhang X, Zheng S et al. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol 2007-04-01 [PMID: 17242184]
Ahmed KM, Dong S, Fan M et al. Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res 2006-12-01 [PMID: 17189385] (IP, Human)	IP	Human
Shreeram S, Hee WK, Demidov ON et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006-12-01 [PMID: 17158963]
Kirshner J, Jobling MF, Pajares MJ et al. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res 2006-11-01 [PMID: 17090522]
Henderson MJ, Munoz MA, Saunders DN et al. EDD mediates DNA damage-induced activation of CHk2. J Biol Chem 2006-12-01 [PMID: 17074762]
Liu Y, Rusinol A, Sinensky M et al. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci 2006-11-01 [PMID: 17062639] (ICC/IF, Human)	ICC/IF	Human
Shreeram S, Demidov ON, Hee WK et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 2006-09-01 [PMID: 16949371] (IP, Human)	IP	Human
Wu X, Shell SM, Liu Y et al. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene 2007-02-01 [PMID: 16862173] (WB, Human)	WB	Human
Kozlov SV, Graham ME, Peng C et al. Involvement of novel autophosphorylation sites in ATM activation. EMBO J 2006-08-09 [PMID: 16858402] (WB, Human)	WB	Human
Tatsumi Y, Sugimoto N, Yugawa T et al. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci 2006-08-01 [PMID: 16835273] (WB, Human)	WB	Human
Jiang X, Sun Y, Chen S et al. The FATC domains of PIkk proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-Pkcs and ATM. J Biol Chem 2006-06-01 [PMID: 16603769] (WB, Human)	WB	Human
Gueven N, Becherel OJ, Birrell G et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res 2006-03-01 [PMID: 16540636]
Shiotani B, Kobayashi M, Watanabe M et al. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res 2006-02-01 [PMID: 16513843] (WB, Human)	WB	Human
Freiberg RA, Hammond EM, Dorie MJ et al. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol 2006-03-01 [PMID: 16478982] (WB, Human)	WB	Human
Aglipay JA, Martin SA, Tawara H et al. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem 2006-04-01 [PMID: 16452482] (WB, Human)	WB	Human
Wang HC, Chou WC, Shieh SY et al. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res 2006-02-01 [PMID: 16452194]
Pusapati RV, Rounbehler RJ, Hong S et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci USA 2006-01-01 [PMID: 16432227]
Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res 2005-12-01 [PMID: 16322218] (WB, Human)	WB	Human
Shi Y, Dodson GE, Shaikh S et al. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem 2005-12-01 [PMID: 16221684]
Sun Y, Jiang X, Chen S et al. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci USA 2005-09-01 [PMID: 16141325] (IP, Human)	IP	Human
Kim JS, Krasieva TB, Kurumizaka H et al. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol 2005-08-01 [PMID: 16061690] (ICC/IF, Human)	ICC/IF	Human
Young DB, Jonnalagadda J, Gatei M et al. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem 2005-07-01 [PMID: 15929992] (ELISA, Human)	ELISA	Human
Wang J, Pluth JM, Cooper PK et al. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) 2005-05-01 [PMID: 15811628]
Peng Y, Woods RG, Beamish H et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005-03-01 [PMID: 15753361]
Li J, Stern DF. Regulation of CHk2 by DNA-dependent protein kinase. J Biol Chem 2005-03-01 [PMID: 15668230] (WB, Human)	WB	Human
Kudoh A, Fujita M, Zhang L et al. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem 2005-03-01 [PMID: 15611093]
Xu X, Lee J, Stern DF et al. Microcephalin is a DNA damage response protein involved in regulation of CHk1 and BRCA1. J Biol Chem 2004-08-01 [PMID: 15220350]
Dodson GE, Shi Y, Tibbetts RS. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem 2004-08-01 [PMID: 15197179] (FLOW, Human)	FLOW	Human
Dork T, Bendix-Waltes R, Wegner RD et al. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A 2004-04-01 [PMID: 15054841] (WB, Human)	WB	Human
Naka K, Tachibana A, Ikeda K et al. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem 2004-01-01 [PMID: 14570874]
Vemuri MC, Schiller E, Naegele JR. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ;8(3):245-55. 2001-03-01 [PMID: 11319607]
Scherthan H, Jerratsch M, Dhar S et al. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol 2000-10-01 [PMID: 11003672] (ICC/IF)	ICC/IF
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Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Yongkang Yang	IP	Human	10/28/2020	View Summary Application Immunoprecipitation Sample Tested MDA-MB-231 Species Human Lot 43444
Enlarge	5 reviewed by: Verified Customer	WB	Human	04/28/2015	View Summary Application Western Blot Species Human
	4 reviewed by: Takeshi Shi	WB	Human	11/02/2014	View Summary Application Western Blot Sample Tested U2OS whole cell lysate Species Human

Array NB100-309

• ATM Antibodies
• ATM ELISA Kits
• ATM Proteins