USP9x Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

USP9x (ubiquitin-specific protease 9, X chromosome) is one of the largest deubiquitinases (DUBs) belonging to the Ub-specific protease family and implicates in processing of ubiquitin precursors as well as of ubiquitinated proteins, thereby playing a key regulatory role at protein turnover level by preventing degradation of proteins through conjugated ubiquitin removal. USP9X substrates include AF-6, beta-catenin, NUAK1, MARK4, ErbB2, EFA6, Smad4, Mcl1, ASK1, and survivin, and USP9X has been involved in several biological processes that include: protein trafficking and tight junction biogenesis in epithelial cells; regulation of the TGF-beta pathway; chromosome alignment and segregation; component of PEX5-mediated peroxisomal protein import pathway. Moreover, USP9X modulates the proteins levels of: alpha-synuclein, a protein involved in the pathogenesis of Parkinson disease; MCL1, an anti-apoptotic protein generally found overexpressed in cancers; some protein kinases involved in stress responses and cellular energy homeostasis; and some ubiquitin-ligases, such as MARCH7 and Itch.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-48321	Applications	Species
Bodiga Vl, Vemuri Pk, Nimmagadda G, Bodiga S Zinc-dependent changes in oxidative and endoplasmic reticulum stress during cardiomyocyte hypoxia/reoxygenation Biol. Chem. 2020-06-01 [PMID: 32549180] (WB)	WB
Asahina, M, Fujinawa, R Et al. Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems. Hum Mol Genet 2020-06-27 [PMID: 32259258] (WB, Mouse)	WB	Mouse
Dietachmayr M, Rathakrishnan A, Karpiuk O et Al. Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival Nat Commun 2020-03-09 [PMID: 32152317] (WB, Human)	WB	Human
Perez-Mancera PA, Rust AG, van der Weyden L et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 2012-04-01 [PMID: 22699621] (IF/IHC, Human)	IF/IHC	Human
Tian R, Cheng H-YM, Figeys D. Uncovering the proteome response of the master circadian clock to light using an AutoProteome system. Mol Cell Proteomics. 2011-08-22 [PMID: 21859948] (ICC/IF, Mouse)	ICC/IF	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Andrea Cerase	IF	Mouse	08/15/2011	View Summary Application Immunofluorescence Sample Tested Mouse ES cell line (129) Species Mouse Lot A1

Array NBP1-48321

• USP9x Antibodies