POMC Antibody

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Mouse, Rat, Porcine, Sheep.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-1533	Applications	Species
Wang Z, Khor S, Cai D. Age-dependent decline of hypothalamic HIF2a in response to insulin and its contribution to advanced age-associated metabolic disorders in mice J. Biol. Chem. 2019-02-01 [PMID: 30709906] (ICC/IF, Mouse)	ICC/IF	Mouse
Mandal SK, Briski KP. Hindbrain Dorsal Vagal Complex AMPK Controls Hypothalamic Gluco-regulatory Transmitter and Counter-Regulatory Hormone Responses to Hypoglycemia. Brain Res. Bull. 2018-11-24 [PMID: 30481553] (WB, Rat)	WB	Rat
Shakya M, Shrestha PK, Briski KP et al. Hindbrain 5'-adenosine monophosphate-activated protein kinase Mediates Short-Term Food Deprivation Inhibition of the Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide Neuroscience. 2018-05-06 [PMID: 29746990] (WB, Rat)	WB	Rat
Kim GH, Shi G, Somlo DR, Haataja L. Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. J. Clin. Invest. 2018-02-19 [PMID: 29457782] (IF/IHC, Mouse)	IF/IHC	Mouse
Klasvogt S, Zuschratter W, Schmidt A et al. Air-liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2. Cell Death Discov. 2017-03-02 [PMID: 28250970] (WB, Porcine)	WB	Porcine
Trebak F, Dubuc I, Arabo A et al. A Potential Role for the Secretogranin II-Derived Peptide EM66 in the Hypothalamic Regulation of Feeding Behavior. J. Neuroendocrinol. 2017-02-06 [PMID: 28166374]
Evans JF, Rodriguez S, Ragolia L. ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling. Cell Tissue Res 2013-01-29 [PMID: 23358747] (WB, Rat)	WB	Rat
Evans JF, Fernando A, Ragolia. Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells Mol Cell Endocrinol 2012-05-15 [PMID: 22306084] (WB, Mouse)	WB	Mouse
Kaushik S, Arias E, Kwon H et al. Loss of autophagy in hypothalamic POMC neurons impairs lipolysis EMBO Rep 2012-03-01 [PMID: 22249165] (ICC/IF, IF/IHC, WB, Mouse)	ICC/IF, IF/IHC, WB	Mouse
Muhlhausler B, Adam C, Marrocco E et al. Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. J Physiol. 2005-05-15 [PMID: 15661821] (Sheep)		Sheep

Array NB100-1533

• POMC Antibodies
• POMC ELISA Kits
• POMC Lysate
• POMC Proteins