Smad7 Antibody

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily (1). SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD5, SMAD8 and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature. Human SMAD1 is a 465 amino acid protein; GenBank Accession No. AAP36050.1. Human SMAD2 is a 467 amino acid protein; GenBank Accession No. AAC51918.1 Human SMAD3 is a 425 amino acid protein; GenBank Accession No. NP_005893.1 Human SMAD4 is a 552 amino acid protein GenBank Accession No. NP_005350.1. Human SMAD5 is a 465 amino acid protein; GenBank Accession No. AAC50791.1. Human SMAD6 is a 496 amino acid protein; GenBank Accession No. AAH12986.1 Human SMAD7 is a 426 amino acid protein; GenBank Accession No. AAB81354.1 Mouse SMAD8 is a 430 amino acid protein; GenBank Accession No. AAN85445.1 Human SMAD9 is a 430 amino acid protein; GenBank Accession No. NP_005896.1

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Sheep.

We have publications tested in 3 applications: ELISA, IF/IHC, WB.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using NBP2-24710	Applications	Species
Takafumi Shichijo, Jun-ichirou Yasunaga, Kei Sato, Kisato Nosaka, Kosuke Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L. Murphy, Roberta L. Bruhn, Ki-Ryang Koh, Hirofumi Akari, Terumasa Ikeda, Reuben S. Harris, Patrick L. Green, Masao Matsuoka Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses Proceedings of the National Academy of Sciences of the United States of America 2024-03-19 [PMID: 38502701]
Tang Y, Du E, Wang G et al. A negative feedback loop centered on SMAD3 expression in transforming growth factor ?1-induced corneal myofibroblast differentiation Experimental eye research 2023-09-19 [PMID: 37734427] (WB, Human)	WB	Human
Shrestha R, Mohankumar K, Safe S Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGF beta-induced invasion of embryonal rhabdomyosarcoma cells American journal of cancer research 2020-08-01 [PMID: 32905449] (WB, Human)	WB	Human
Yang P, Dong X, Zhang Y MicroRNA profiles in plasma samples from young metabolically healthy obese patients and miRNA-21 are associated with diastolic dysfunction via TGF- beta 1/Smad pathway J. Clin. Lab. Anal. 2020-02-28 [PMID: 32108968] (ELISA, Human)	ELISA	Human
Tang Y, Reissig S, Glasmacher E et al. Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis Gastroenterology 2019-02-01 [PMID: 30315770] (WB, Mouse)	WB	Mouse
Singha PK, Pandeswara S, Geng H et al. TGF-b induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer. Genes Cancer. 2014-09-01 [PMID: 25352949] (WB, Human)	WB	Human
Chang W, Wei K, Ho L et al. A Critical Role for the mTORC2 Pathway in Lung Fibrosis PLoS ONE 2014-08-28 [PMID: 25162417] (WB, Human) Details: SMAD7 antibody used for WB on lysates of fibroblasts (isolated from the surgical lung explants 0 Idiopathic Pulmonary Fibrosis /IPF) stimulated with TGF beta and treated or not with inhibitors MLN0128 (0.2 uM), PP242 (2 uM), or rapamycin (0.02 uM).	WB	Human
Kayalar O, Oztay F. Retinoic acid induced repair in the lung of adult hyperoxic mice, reducing transforming growth factor-B1 (TGF-B1) mediated abnormal alterations. Acta Histochem. [PMID: 24576683] (WB, Mouse) Details: Citation using the Azide Free form of this antibody.	WB	Mouse
L0nn P, Vanlandewijck M, Raja E et al. Transcriptional induction of salt-inducible kinase 1 by transforming growth factor B leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase. J Biol Chem. 2012-04-13 [PMID: 22378783]
Hogg K, Etherington SL, Young JM et al. Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family. Endocrinology [PMID: 20032053] (IF/IHC, Sheep) Details: Used the Azide Free form of this antibody.	IF/IHC	Sheep
Wang Q, Wang Y, Minto AW et al. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008-12-01 [PMID: 18716028] (WB, Human) Details: WB (human mesangial cells), Fig. 3A.	WB	Human
Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes. Osteoarthritis Cartilage. 2007-12-01 [PMID: 17604656]
Kleiter Ingo, Pedre Xiomara, Mueller Andre M et al. Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis. J Neuroimmunol. 2007-07-01 [PMID: 17553571]
Kidd M, Modlin IM, Pfragner R et al. Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1. Cancer. 2007-06-15 [PMID: 17469181] Details: WB: SMAD4 (IMG-565) and B-actin (IMG-531). Neoplastic kRJ-I enterochromaffin (EC) cells stimulated with growth factor-B1 (TGFB1), Fig 4.
Show All 14 Publications. Collapse Publications.

Array NBP2-24710

• Smad7 Antibodies
• Smad7 ELISA Kits
• Smad7 Lysate
• Smad7 Proteins