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CTGF/CCN2 Antibody [Unconjugated] - C-terminus

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CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL ...read more
CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human pancreas array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL ...read more
Effect of KIAA1199 knock-down and over-expression on the expression of PLXNB3, SEMA5A and CTGF in fibroblast-like synoviocyte (FLS) cells. (A). Real-time PCR of KIAA1199, PLXNB3, SEMA5A and CTGF transfected with ...read more
Overview of Multi-dimensional Microscopic Molecular Profiling (MMMP).The overall MMMP approach is depicted using an example tissue section from normal human duodenum (sample #1.9.7). (a) Slides were subjected to ...read more
Effect of KIAA1199 knock-down and over-expression on the expression of PLXNB3, SEMA5A and CTGF in fibroblast-like synoviocyte (FLS) cells. (A). Real-time PCR of KIAA1199, PLXNB3, SEMA5A and CTGF transfected with ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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CTGF/CCN2 Antibody [Unconjugated] - C-terminus Summary

Immunogen
E. coli-derived recombinant human CTGF/CCN2 C-Terminus
Glu247-Ala349
Accession # P29279
Specificity
Detects human CTGF/CCN2 C-Terminus in direct ELISAs. In direct ELISAs, approximately 15% cross‑reactivity with recombinant rat CTGF is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
CTGF
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL
Application Notes
Use in FLOW application reported in PMID: 22493011
Publications
Read Publications using
AF660 in the following applications:

Reactivity Notes

Reactivity with Mouse is reported in PMIDs: 22493011 and 21602472

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CTGF/CCN2 Antibody [Unconjugated] - C-terminus

  • CCN2
  • CCN2IGFBP-8
  • connective tissue growth factor
  • CTGF
  • CTGRP
  • Fisp12
  • HCS24
  • Hypertrophic chondrocyte-specific protein 24
  • IBP-8
  • IGF-binding protein 8
  • IGFBP-8
  • IGFBP8CCN family member 2
  • Insulin-like growth factor-binding protein 8
  • MGC102839
  • NOV2

Background

CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CTGF/CCN2 Antibody (AF660)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC-P, Western Blot.


Filter By Application
IHC-P
(2)
Western Blot
(1)
All Applications
Filter By Species
Human
(1)
Mouse
(1)
Rat
(1)
All Species
Showing Publications 1 - 7 of 7.
Publications using AF660 Applications Species
Zhaoping Qin, Tianyuan He, Chunfang Guo, Taihao Quan Age-Related Downregulation of CCN2 Is Regulated by Cell Size in a YAP/TAZ-Dependent Manner in Human Dermal Fibroblasts: Impact on Dermal Aging JID Innovations 5/1/2022 [PMID: 35480397]
Jun Yoshino, Bruce W. Patterson, Samuel Klein Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans Obesity (Silver Spring) 6/1/2019 [PMID: 31004409]
Riordan D, Varma S, West R, Brown P Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PLoS ONE, 2015-07-15;10(7):e0128975. 2015-07-15 [PMID: 26176839] (IHC-P, Human) IHC-P Human
Yang X, Qiu PC, Chen BB et al. KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis. Arthritis Research & Therapy. 1/1/2015 [PMID: 26022278]
Finger EC, Cheng CF, Williams TR et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2/25/2013 [PMID: 23435419]
McCurdy S, Dai Q, Zhang J, Zamilpa R, Ramirez T, Dayah T, Nguyen N, Jin Y, Bradshaw A, Lindsey M SPARC mediates early extracellular matrix remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol, 2011-05-20;301(2):H497-505. 2011-05-20 [PMID: 21602472] (Western Blot, Mouse) Western Blot Mouse
Inkinen K, Wolff H, Lindroos P, Ahonen J Connective tissue growth factor and its correlation to other growth factors in experimental granulation tissue. Connect. Tissue Res., 2003-01-01;44(1):19-29. 2003-01-01 [PMID: 12945801] (IHC-P, Rat) IHC-P Rat

Reviews for CTGF/CCN2 Antibody (AF660) (0)

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FAQs for CTGF/CCN2 Antibody (AF660). (Showing 1 - 1 of 1 FAQs).

  1. We are looking for a pair of mouse CTGF antibody for ELISA, we prefer no azide and/or glycerol, and in carrier free form (no EDTA, no Tris, no BSA). For the validation, we need approximately 100ug. If it works, we'll order more later.
    • Unfortunately we do not carry any CTGF antibodies that suit your specifications. We do carry AbSelect antibody purification kits that will remove BSA, Tris and azide from antibody formulations which may be an option for you.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol CTGF
Uniprot