Human Serpin E1/PAI-1 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

We have publications tested in 2 confirmed species: Human, Primate - Chlorocebus aethiops (African Green Monkey).

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using DSE100	Applications	Species
Domingo, JC;Battistini, F;Cordobilla, B;Zaragozá, MC;Sanmartin-Sentañes, R;Alegre-Martin, J;Cambras, T;Castro-Marrero, J; Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study Journal of translational medicine 2024-04-10 [PMID: 38600563] (Human)		Human
Richards, A;Khalil, A;Friesen, M;Whitfield, TW;Lungjangwa, T;Gehrke, L;Mooney, D;Jaenisch, R; SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection bioRxiv : the preprint server for biology 2023-08-07 [PMID: 37609322] (Human)		Human
E Wo?nica-Ni, P Le?nik, J Janc, M Zalewska, L ?ysenko The Role of Plasminogen Activator Inhibitor 1 in Predicting Sepsis-Associated Liver Dysfunction: An Observational Study International Journal of Environmental Research and Public Health, 2023-03-09;20(6):. 2023-03-09 [PMID: 36981754] (Human)		Human
P Poplawski, S Alseekh, U Jankowska, B Skupien-Ra, R Iwanicka-N, H Kossowska, A Fogtman, B Rybicka, J Bogus?awsk, A Adamiok-Os, K Hanusek, J Hanusek, M Koblowska, AR Fernie, A Piekie?ko- Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration Cancer Cell International, 2023-01-05;23(1):2. 2023-01-05 [PMID: 36604669] (Human)		Human
AD Ruggiero, R Vemuri, M Block, D DeStephani, M Davis, J Chou, A Williams, A Brock, SK Das, K Kavanagh Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity International Journal of Molecular Sciences, 2022-10-21;23(20):. 2022-10-21 [PMID: 36293536] (Primate - Chlorocebus aethiops (African Green Monkey))		Primate - Chlorocebus aethiops (African Green Monkey)
BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot Human iPSC co-culture model to investigate the interaction between microglia and motor neurons Scientific Reports, 2022-07-23;12(1):12606. 2022-07-23 [PMID: 35871163] (Human)		Human
E Schapkaitz, E Libhaber, BF Jacobson, M Toman, A Gerber, HR Büller Evaluation of markers of fibrinolysis and coagulation in pregnant women with human immunodeficiency virus Thrombosis Research, 2022-07-07;217(0):1-8. 2022-07-07 [PMID: 35810616] (Human)		Human
KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19 JCI Insight, 2022-05-09;7(9):. 2022-05-09 [PMID: 35298440] (Human)		Human
Y Qin, J Zhang, S Babapoor-F, B Applewhite, M Deshpande, H Megarity, M Flores-Bel, S Aparicio-D, T Ma, Y Rui, SY Tzeng, JJ Green, MV Canto-Sole, S Montaner, A Sodhi PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients Science Advances, 2022-03-02;8(9):eabm1896. 2022-03-02 [PMID: 35235351] (Human)		Human
C Cohen, O Le Goff, F Soysouvanh, F Vasseur, M Tanou, C Nguyen, L Amrouche, J Le Guen, O Saltel-Ful, T Meunier, T Nguyen-Kho, M Rabant, D Nochy, C Legendre, G Friedlande, BG Childs, DJ Baker, B Knebelmann, D Anglicheau, F Milliat, F Terzi Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1 Embo Molecular Medicine, 2021-11-02;13(11):e14146. 2021-11-02 [PMID: 34725920] (Human)		Human
M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients Molecular and Cellular Biology, 2021-11-01;0(0):MCB0046721. 2021-11-01 [PMID: 34723652] (Human)		Human
SH Cho, JH Kim, HJ An, YR Kim, EH Ahn, JR Lee, JO Kim, JJ Ko, NK Kim Genetic Polymorphisms in miR-604A>G, miR-938G>A, miR-1302-3C>T and the Risk of Idiopathic Recurrent Pregnancy Loss International Journal of Molecular Sciences, 2021-06-07;22(11):. 2021-06-07 [PMID: 34200157] (Human)		Human
C Voukalis, GYH Lip, E Shantsila Effects of antithrombotic drugs on the prothrombotic state in patients with atrial fibrillation: The west Birmingham atrial fibrillation project Thrombosis Research, 2021-02-09;200(0):149-155. 2021-02-09 [PMID: 33610887] (Human)		Human
YY Wang, HD Chen, S Lo, YK Chen, YC Huang, SC Hu, YC Hsieh, AC Hung, MF Hou, SF Yuan Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages Cancers, 2020-11-26;12(12):. 2020-11-26 [PMID: 33256011] (Human)		Human
L Peng, Y Ye, H Mullikin, L Lin, C Kuhn, M Rahmeh, S Mahner, U Jeschke, V von Schönf Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines J Reprod Immunol, 2020-10-01;142(0):103210. 2020-10-01 [PMID: 33011635] (Human)		Human
K Zmajkovico, Y Bauer, K Menyhart, M Schnoebele, D Freti, M Boucher, B Renault, R Studer, M Birker-Rob, A Klenk, O Nayler, J Gatfield GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFbeta1 PLoS ONE, 2020-02-13;15(2):e0228195. 2020-02-13 [PMID: 32053631] (Human)		Human
N Hao, TT Chiou, CH Wu, YY Lei, PL Liang, MC Chao, H Yang, JB Chen Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients Biomed Res Int, 2019-05-05;2019(0):2152584. 2019-05-05 [PMID: 31192253] (Human)		Human
Y Ye, C Kuhn, M Kösters, GJ Arnold, H Ishikawa-A, C Schulz, N Rogenhofer, CJ Thaler, S Mahner, T Fröhlich, U Jeschke, V von Schönf Anti ?-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages EBioMedicine, 2019-03-01;0(0):. 2019-03-01 [PMID: 30827932] (Human)		Human
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, SK Hashmi, L Prata, MM Masternak, SB Kritchevsk, N Musi, JL Kirkland Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study EBioMedicine, 2019-01-05;0(0):. 2019-01-05 [PMID: 30616998] (Human)		Human
Y Ye, A Vattai, N Ditsch, C Kuhn, M Rahmeh, S Mahner, M Ripphahn, R Immler, M Sperandio, U Jeschke, V von Schoen Prostaglandin E2 receptor 3 (EP3) signaling is induced in placentas with unexplained recurrent pregnancy losses (uRPL) Endocr Connect, 2018-04-26;0(0):. 2018-04-26 [PMID: 29700097] (Human)		Human
M Jakubowski, J D?bski, E Szahidewic, A Turek-Jaku, J Gawry?, K Gawry?, R Skomro, A Derkacz, A Doroszko Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance Oxid Med Cell Longev, 2017-09-27;2017(0):3132063. 2017-09-27 [PMID: 29090039] (Human)		Human
S Chen, H Jiang, Y Liu, Z Hou, Y Yue, Y Zhang, F Zhao, Z Xu, Y Li, X Mou, L Li, T Wang, J Zhao, C Han, Y Sui, M Wang, Z Yang, Y Lu, Y Zhu, J Li, X Shen, F Sun, Q Chen, H Chen, Y Yuan Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders Sci Rep, 2017-07-31;7(1):6871. 2017-07-31 [PMID: 28761093] (Human)		Human
Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies Sci Rep, 2016-07-26;6(0):30464. 2016-07-26 [PMID: 27456456] (Human)		Human
Rolandsson Enes S, Andersson Sjoland A, Skog I, Hansson L, Larsson H, Le Blanc K, Eriksson L, Bjermer L, Scheding S, Westergren-Thorsson G MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC. Sci Rep, 2016-07-06;6(0):29160. 2016-07-06 [PMID: 27381039] (Human)		Human
MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis PLoS ONE, 2016-05-04;11(5):e0154874. 2016-05-04 [PMID: 27144281] (Human)		Human
Circadian misalignment increases cardiovascular disease risk factors in humans Proc. Natl. Acad. Sci. U.S.A., 2016-02-08;113(10):E1402-11. 2016-02-08 [PMID: 26858430] (Human)		Human
Chang M, Chang H, Chan C, Yeung S, Hsien H, Lin B, Yeh C, Tseng W, Tseng S, Jeng J p-Cresol affects reactive oxygen species generation, cell cycle arrest, cytotoxicity and inflammation/atherosclerosis-related modulators production in endothelial cells and mononuclear cells. PLoS ONE, 2014-12-17;9(12):e114446. 2014-12-17 [PMID: 25517907] (Human)		Human
Masia M, Robledano C, Ortiz de la Tabla V, Antequera P, Lumbreras B, Hernandez I, Gutierrez F Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients. PLoS ONE, 2014-08-18;9(8):e105442. 2014-08-18 [PMID: 25133669] (Human)		Human
Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling. FEBS Open Bio, 2014-04-01;4(0):353-61. 2014-04-01 [PMID: 24918049] (Human)		Human
Portilla J, Moreno-Perez O, Serna-Candel C, Escoin C, Alfayate R, Reus S, Merino E, Boix V, Giner L, Sanchez-Paya J, Pico A Vitamin D insufficiency and subclinical atherosclerosis in non-diabetic males living with HIV. J Int AIDS Soc, 2014-05-13;17(0):18945. 2014-05-13 [PMID: 24836607] (Human)		Human
Hernandez S, Gong J, Chen L, Wu I, Sun J, Keenan H, King G Characterization of circulating and endothelial progenitor cells in patients with extreme-duration type 1 diabetes. Diabetes Care, 2014-04-29;37(8):2193-201. 2014-04-29 [PMID: 24780357] (Human)		Human
Fujimura K, Wakino S, Minakuchi H, Hasegawa K, Hosoya K, Komatsu M, Kaneko Y, Shinozuka K, Washida N, Kanda T, Tokuyama H, Hayashi K, Itoh H Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice. PLoS ONE, 2014-04-18;9(4):e94373. 2014-04-18 [PMID: 24747517] (Human)		Human
Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLoS ONE, 2014-01-23;9(1):e86426. 2014-01-23 [PMID: 24466087] (Human)		Human
Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. Thromb Haemost, 2012-12-13;109(2):280-9. 2012-12-13 [PMID: 23238437] (Human)		Human
Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis. BMC Infect Dis, 2012-06-25;12(0):144. 2012-06-25 [PMID: 22731696] (Human)		Human
Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wornle M, Ribeiro A, Himmelein S, Sitter T, Nelson PJ Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. PLoS ONE, 2012-04-27;7(4):e33963. 2012-04-27 [PMID: 22558080] (Human)		Human
Lira FS, Pimentel GD, Santos RV, Oyama LM, Damaso AR, Oller do Nascimento CM, Viana VA, Boscolo RA, Grassmann V, Santana MG, Esteves AM, Tufik S, de Mello MT Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner. Lipids Health Dis, 2011-07-06;10(0):113. 2011-07-06 [PMID: 21733182] (Human)		Human
Zhang P, Moudgill N, Hager E, Tarola N, Dimatteo C, McIlhenny S, Tulenko T, DiMuzio PJ Endothelial differentiation of adipose-derived stem cells from elderly patients with cardiovascular disease. Stem Cells Dev., 2010-11-01;20(6):977-88. 2010-11-01 [PMID: 20879833] (Human)		Human
Ma Z, Kwong KY, Tovar JP, Paek D Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells. Biochem. Biophys. Res. Commun., 2010-09-08;400(4):569-74. 2010-09-08 [PMID: 20816667] (Human)		Human
Patel N, Sundaram N, Yang M Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J. Biol. Chem., 2010-03-29;285(22):16713-22. 2010-03-29 [PMID: 20351105] (Human)		Human
Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ Human CD4- 8- T cells are a distinctive immunoregulatory subset. FASEB J, 2010-02-12;24(7):2558-66. 2010-02-12 [PMID: 20154266] (Human)		Human
Chang W, Wei K, Jacobs SS, Upadhyay D, Weill D, Rosen GD SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin. J. Biol. Chem., 2010-01-08;285(11):8196-206. 2010-01-08 [PMID: 20061390] (Human)		Human
Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J. Pathol., 2009-05-01;218(1):131-42. 2009-05-01 [PMID: 19224541] (Human)		Human
Tkachuk N, Kiyan J, Tkachuk S, Kiyan R, Shushakova N, Haller H, Dumler I Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus. Biochem. J., 2008-10-15;415(2):265-73. 2008-10-15 [PMID: 18564064] (Human)		Human
Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest., 2008-05-01;118(5):1645-56. 2008-05-01 [PMID: 18431508] (Human)		Human
Show All 45 Publications. Collapse Publications.

Array DSE100

• Serpin E1/PAI-1 Antibodies
• Serpin E1/PAI-1 Antibody Pair
• Serpin E1/PAI-1 ELISA Kits
• Serpin E1/PAI-1 Lysate
• Serpin E1/PAI-1 Proteins
• Serpin E1/PAI-1 ELISAs
• Serpin E1/PAI-1 Proteins and Enzyme