SIGIRR Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL1RAPL1), and TIGIRR-1 (IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Five of the IL-1 R family members (1, 2, 4, 5, and 6) are clustered and localized to chromosome 2. SIGIRR (single Ig domain containing IL-1 receptor-related molecule) is a subtype of the IL-1 R family that differs from the other nine members by having only one Ig domain in its extracellular region. The sequence of human SIGIRR predicts a 410 amino acid (aa) residue transmembrane glycoprotein that lacks signal peptide and contains a 118 aa single Ig extracellular domain, a transmembrane region and a 268 aa cytoplasmic tail with a TIR domain. The cytoplasmic tail of SIGIRR contains a C-terminal extention beyond the TIR domain which is also found in IL1RAPL1, IL-1 R9, and Toll-like receptor family members but absent in other IL-1 receptor family members. SIGIRR is widely expressed and is present in all cells and tissues examined. Mouse and human SIGIRR share 82% amino acid sequence identity. The ligand and signaling mechanism for SIGIRR has not been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Goat.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC-Fr, IHC-P, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF990	Applications	Species
K Ueno-Shuto, S Kamei, M Hayashi, A Fukuyama, Y Uchida, N Tokutomi, MA Suico, H Kai, T Shuto A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells International Journal of Molecular Sciences, 2022-07-13;23(14):. 2022-07-13 [PMID: 35887095] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
J Filipe, V Bronzo, G Curone, B Castiglion, D Vigo, B Smith, V Herrera, P Roccabianc, P Moroni, F Riva Staphylococcus aureus intra-mammary infection affects the expression pattern of IL-R8 in goat Comp. Immunol. Microbiol. Infect. Dis., 2019-07-30;66(0):101339. 2019-07-30 [PMID: 31437679] (IHC-P, Goat)	IHC-P	Goat
Ueno-Shuto K, Kato K, Tasaki Y, Sato M, Sato K, Uchida Y, Sakai H, Ono T, Suico M, Mitsutake K, Tokutomi N, Kai H, Shuto T Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils. J Biol Chem, 2014-05-12;289(26):18097-109. 2014-05-12 [PMID: 24821721] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Khan MA, Steiner TS, Sham HP, Bergstrom KS, Huang JT, Assi K, Salh B, Tai IT, Li X, Vallance BA The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. J. Immunol., 2010-02-03;184(5):2305-13. 2010-02-03 [PMID: 20130217] (ICC, IHC-Fr, Human)	ICC, IHC-Fr	Human

Array AF990

• SIGIRR Antibodies
• SIGIRR Lysates
• SIGIRR Proteins
• SIGIRR Proteins and Enzymes