SIGIRR Products

Description

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Bioinformatics

Entrez	24058 Mouse 59307 Human
Uniprot	AAH03591 Human CAG33619 Human NM_021805 Human NP_001128525 Human NP_001128526 Human Q6IA17 Human Q9JLZ8 Mouse
Product By Gene ID	59307
Alternate Names	single Ig IL-1-related receptor Single Ig IL-1R-related molecule single immunoglobulin and toll-interleukin 1 receptor (TIR) domain single immunoglobulin domain IL1R1 related Single immunoglobulin domain-containing IL1R-related protein TIR8MGC110992 Toll/interleukin-1 receptor 8