RUNX3/CBFA3 Antibody (527327) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

RUNX3, also called CBFA3, AML-2 or PEBP2-alpha C, is a member of the Runt domain family of nuclear transcriptional regulators. All of the RUNX proteins form dimers with CBF-beta . The runt domain (aa 54-186) is required for DNA binding, while a pro/ser/thr-rich region (aa 191-415) transcriptionally activates target genes. Isoform 2 has an alternate 19 aa in place of the N-terminal 5 aa of isoform 1. The 415 aa Human RUNX3 shares 91% aa identity with mouse or rat RUNX3. RUNX3 is necessary for growth control of gastric epithelium, neurogenesis of dorsal root ganglia, and T cell differentiation. RUNX3 expression is frequently mutated in tumors and appears to be silenced by methylation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Flow Cytometry, ICC, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB3765	Applications	Species
Wenjun Yang, Yaqi Wang, Yuanyuan Du, Jiyong Li, Minzhi Jia, Sheng Li et al. Chemical reprogramming of melanocytes to skeletal muscle cells Journal of Cachexia, Sarcopenia and Muscle 4/1/2023 [PMID: 36726338]
F Facciotti, P Larghi, R Bosotti, C Vasco, N Gagliani, C Cordiglier, S Mazzara, V Ranzani, E Rottoli, S Curti, A Penatti, B Karnani, Y Kobayashi, M Crosti, M Bombaci, JP van Hambur, G Rossetti, R Gualtierot, M Gerosa, S Gatti, S Torretta, L Pignataro, SW Tas, S Abrignani, M Pagani, F Grassi, PL Meroni, RA Flavell, J Geginat Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus Proc. Natl. Acad. Sci. U.S.A., 2020-03-17;117(13):7305-7316. 2020-03-17 [PMID: 32184325] (Flow Cytometry, Human)	Flow Cytometry	Human
P Balogh, ER Adelman, JV Pluvinage, BJ Capaldo, KC Freeman, S Singh, KE Elagib, Y Nakamura, R Kurita, G Sashida, ER Zunder, H Li, AA Gru, EA Price, SL Schrier, IL Weissman, ME Figueroa, WW Pang, AN Goldfarb RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance Haematologica, 2019-06-06;0(0):. 2019-06-06 [PMID: 31171641] (ICC, Human)	ICC	Human
AHyun Choi, Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica Tesell, Jun Yu et al. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia Blood 10/12/2017 [PMID: 28790107]
Chopin M, Seillet C, Chevrier S, Wu L, Wang H, Morse H, Belz G, Nutt S Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. J Exp Med, 2013-11-18;210(13):2967-80. 2013-11-18 [PMID: 24249112] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-theta and reactive oxygen species. Nat Med, 2012-10-21;18(11):1693-8. 2012-10-21 [PMID: 23086478] (Western Blot, Mouse)	Western Blot	Mouse

Array MAB3765

• RUNX3/CBFA3 Antibodies
• RUNX3/CBFA3 Lysate
• RUNX3/CBFA3 Proteins