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Coagulation Factor XIV/Protein C Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
Biotin
BAF4885
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF4885-SP
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Coagulation Factor XIV/Protein C Antibody Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant mouse Coagulation Factor XIV/Protein C
Ile19-Leu460
Accession # P33587
Specificity
Detects mouse Coagulation Factor XIV/Protein C in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human Protein C is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
PROC
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF4885 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Coagulation Factor XIV/Protein C Antibody

  • Anticoagulant protein C
  • APC
  • Autoprothrombin IIA
  • Blood coagulation factor XIV
  • Coagulation Factor XIV
  • EC 3.4.21
  • EC 3.4.21.69
  • PC
  • PROC
  • PROC1
  • protein C (inactivator of coagulation factors Va and VIIIa)
  • Protein C
  • vitamin K-dependent protein C

Background

Protein C is a vitamin K-dependent serine protease synthesized in the liver as a single-chain precursor, which is then proteolytically processed to two disulfide-linked chains (1). The light chain consists of a Gla (gamma-carboxy-glutamate) domain and two EGF-like domains. The heavy chain consists of an activation peptide (aa 199‑212) and serine protease domain (aa 213‑449). Physiologically, Protein C is converted to the active form by thrombin, which releases the activation peptide. Protein C plays a key role in anticoagulation, cleaving factors VIIIa and Va to inactivate them. This anticoagulation activity can be enhanced by a presence of a cofactor such as protein S. In hereditary thrombophilia, Protein C deficiency is caused by a genetic mutation that affects Protein C activity. A severe recessive form may result in massive thrombosis fatal to patient.

  1. Shen, L. and Dahlbäck, B. (2004) in Handbook of Proteolytic Enzymes, Barrett, A.J. et al. eds. pp.
    1673.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Coagulation Factor
XIV/Protein C Antibod ...
AF4885
Coagulation Factor XIV/Protein C Antibody
Species: Mu
Applications: WB, IP

Publications for Coagulation Factor XIV/Protein C Antibody (AF4885)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC-P, Immunohistochemistry.


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(1)
Immunohistochemistry
(1)
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Bioinformatics

Gene Symbol PROC
Uniprot