Human peripheral blood mononuclear cells (PBMC) lymphocytes either (A) untreated or (B) treated with PMA were stained with Mouse Anti-Human/Mouse RUNX3/CBFA3 APC-conjugated Monoclonal Antibody (Catalog # IC3765A, filled ...read more
12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for RUNX3/CBFA3 Antibody (527327) [Allophycocyanin]
Acute myeloid leukemia 2 protein
AML2
AML2SL3/AKV core-binding factor alpha C subunit
CBFA3
CBFA3MGC16070
CBF-alpha-3
PEA2 alpha C
PEA2-alpha C
PEBP2 alpha C
PEBP2A3
PEBP2A3FLJ34510
PEBP2AC
PEBP2-alpha C
runt domain, alpha subunit 3
runt-related transcription factor 3
RUNX3
SL3-3 enhancer factor 1 alpha C subunit
transcription factor AML2
Background
RUNX3, also known as CBFA3, AML-2 or PEBP2-alpha C, is a member of the Runt domain family of nuclear transcriptional regulators. All of the RUNX proteins form dimers with CBF-beta . The Runt domain, amino acids (aa) 54-186, is required for DNA binding, while a pro/ser/thr-rich region (aa 191-415) transcriptionally activates target genes. Isoform 2 has an alternate 19 aa in place of the N-terminal 5 aa of isoform 1. The 415 aa Human RUNX3 shares 91% aa identity with mouse or rat RUNX3. RUNX3 is necessary for growth control of gastric epithelium, neurogenesis of dorsal root ganglia, and T cell differentiation. RUNX3 expression is frequently mutated in tumors and appears to be silenced by methylation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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