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RUNX3/CBFA3 Antibody (527327) [Allophycocyanin]

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Product Details

Summary
Applications Flow
Clone
527327
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC3765U-100UG
Alexa Fluor 350
FAB3765U
Alexa Fluor 405
IC3765V-100UG
Alexa Fluor 405
FAB3765V
Alexa Fluor 488
FAB3765G
Alexa Fluor 488
IC3765G-100UG
Alexa Fluor 532
FAB3765X
Alexa Fluor 594
IC3765T-100UG
Alexa Fluor 594
FAB3765T
Alexa Fluor 647
FAB3765R
Alexa Fluor 647
IC3765R-100UG
Alexa Fluor 700
FAB3765N
Alexa Fluor 700
IC3765N-100UG
Alexa Fluor 750
FAB3765S
Alexa Fluor 750
IC3765S-100UG
Allophycocyanin
FAB3765A
Biotin
FAB3765B
DyLight 350
FAB3765D
DyLight 405
FAB3765E
DyLight 488
FAB3765K
DyLight 550
FAB3765L
DyLight 594
FAB3765M
DyLight 650
FAB3765W
DyLight 680
FAB3765Y
DyLight 755
FAB3765Z
FITC
FAB3765F
HRP
FAB3765H
Janelia Fluor 549
FAB3765I
Janelia Fluor 646
FAB3765J
PE
FAB3765P
PerCP
FAB3765C
Unconjugated
MAB3765
mFluor Violet 450 SE
FAB3765MFV450
mFluor Violet 500 SE
FAB3765MFV500
mFluor Violet 610 SE
FAB3765MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB3765
Carrier Free
MAB3765
Carrier Free
MAB3765-SP
Carrier Free
IC3765S-100UG
Carrier Free
IC3765R-100UG
Carrier Free
IC3765N-100UG
Carrier Free
IC3765G-100UG
Carrier Free
IC3765V-100UG
Carrier Free
IC3765U-100UG
Carrier Free
IC3765T-100UG
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RUNX3/CBFA3 Antibody (527327) [Allophycocyanin] Summary

Immunogen
E. coli-derived recombinant human RUNX3/CBFA3
Lys186-Tyr415
Accession # Q13761
Specificity
Detects human and mouse RUNX3/CBFA3 in Western blots.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
RUNX3
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

RUNX3, also known as CBFA3, AML-2 or PEBP2-alpha C, is a member of the Runt domain family of nuclear transcriptional regulators. All of the RUNX proteins form dimers with CBF-beta . The Runt domain, amino acids (aa) 54-186, is required for DNA binding, while a pro/ser/thr-rich region (aa 191-415) transcriptionally activates target genes. Isoform 2 has an alternate 19 aa in place of the N-terminal 5 aa of isoform 1. The 415 aa Human RUNX3 shares 91% aa identity with mouse or rat RUNX3. RUNX3 is necessary for growth control of gastric epithelium, neurogenesis of dorsal root ganglia, and T cell differentiation. RUNX3 expression is frequently mutated in tumors and appears to be silenced by methylation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RUNX3