Recombinant Human IGF-II/IGF2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Insulin-like growth factor I (also known as somatomedin C and somatomedin A) and insulin-like growth factor II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved (100% identity between human, bovine and porcine proteins) and exhibit cross-species activity.

IGF-II is a potent mitogenic growth factor. However, unlike IGF-I which has important postnatal roles, the growth-promoting function of IGF-II is limited to embryonic development.

Two specific cell surface receptors that bind IGF-I and IGF-II have been identified. The type I IGF receptor that participates in IGF signaling is structurally related to the insulin receptor. It is a disulfide-linked heterotetrameric transmembrane glycoprotein with an intracellular tyrosine kinase domain. Type I IGF receptor binds IGF-I with higher affinity than IGF-II. The type II IGF receptor which binds IGF-II with much higher affinity than IGF-I is also the cation-independent mannose 6-phosphate receptor. At the present time, it is not known if the type II IGF receptor participates in the IGF signaling pathway. An additional unknown receptor which mediates IGF‑II signaling has also been proposed. Circulating IGFs exist in complexes bound to IGF binding proteins. Currently, at least six high affinity binding proteins have been identified.

We have publications tested in 7 confirmed species: Human, Mouse, Rat, Bovine, Chicken, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca nemestrina (Southern Pig-tailed Macaque).

We have publications tested in 10 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Capture), ELISA (Standard), ELISA Capture, Enzyme Assay Substrate, In Vivo, Library Screening, Western Blot.

Showing Publications 1 - 10 of 48. Show All 48 Publications. Collapse Publications.

Publications using 292-G2	Applications	Species
Abello, J;Yin, Y;Zhao, Y;Maurer, J;Lee, J;Bodell, C;Clevenger, AJ;Burton, Z;Goeckel, ME;Lin, M;Grainger, S;Halabi, CM;Raghavan, SA;Sah, R;Stratman, AN; Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries bioRxiv : the preprint server for biology 2024-06-12 [PMID: 38915529] (Bioassay, Human)	Bioassay	Human
Johnson, D;Colijn, S;Richee, J;Yano, J;Burns, M;Davis, AE;Pham, VN;Saric, A;Jain, A;Yin, Y;Castranova, D;Melani, M;Fujita, M;Grainger, S;Bonifacino, JS;Weinstein, BM;Stratman, AN; Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1 bioRxiv : the preprint server for biology 2024-04-01 [PMID: 38903077] (Bioassay, Human)	Bioassay	Human
Majlessipour, F;Zhu, G;Baca, N;Kumbaji, M;Hwa, V;Danielpour, M; Skeletal overgrowth in a pre-pubescent child treated with pan-FGFR inhibitor Heliyon 2024-06-15 [PMID: 38841436] (Bioassay, Human)	Bioassay	Human
Goeckel, ME;Lee, J;Levitas, A;Colijn, S;Mun, G;Burton, Z;Chintalapati, B;Yin, Y;Abello, J;Stratman, A; CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment bioRxiv : the preprint server for biology 2023-09-17 [PMID: 37745440] (Cell Culture, Human)	Cell Culture	Human
Waldrep, KM;Rodgers, JI;Garrett, SM;Wolf, BJ;Feghali-Bostwick, CA; The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis International journal of molecular sciences 2023-07-08 [PMID: 37510994] (Bioassay, Human)	Bioassay	Human
CA Conover, LK Bale Senescence induces proteolytically-active PAPP-A secretion and association with extracellular vesicles in human pre-adipocytes Experimental gerontology, 2022-12-20;172(0):112070. 2022-12-20 [PMID: 36549546] (Bioassay, Human)	Bioassay	Human
JS Lee, MW Lero, J Mercado-Ma, S Zhu, M Jo, CE Tocheny, JS Morgan, LM Shaw The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC Cell Reports, 2022-12-06;41(10):111759. 2022-12-06 [PMID: 36476848] (Bioassay, Human)	Bioassay	Human
S Funakoshi, I Fernandes, O Mastikhina, D Wilkinson, T Tran, W Dhahri, A Mazine, D Yang, B Burnett, J Lee, S Protze, GD Bader, SS Nunes, M Laflamme, G Keller Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells Nature Communications, 2021-05-26;12(1):3155. 2021-05-26 [PMID: 34039977] (Bioassay, Human)	Bioassay	Human
CM Hammerle, I Sandovici, GV Brierley, NM Smith, WE Zimmer, I Zvetkova, HM Prosser, Y Sekita, BYH Lam, M Ma, WN Cooper, A Vidal-Puig, SE Ozanne, G Medina-Góm, M Constância Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function PLoS Genet, 2020-10-15;16(10):e1009069. 2020-10-15 [PMID: 33057429] (Western Blot, Mouse)	Western Blot	Mouse
L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21 Aging (Albany NY), 2020-04-17;12(8):6823-6851. 2020-04-17 [PMID: 32302288] (Cell Culture, Human)	Cell Culture	Human
R Wang, X Qi, P Schmiege, E Coutavas, X Li Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 2020-02-12;6(7):eaaz1466. 2020-02-12 [PMID: 32095534] (Binding Assay, Human)	Binding Assay	Human
I Rooda, K Hensen, B Kaselt, S Kasvandik, M Pook, A Kurg, A Salumets, A Velthut-Me Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells Sci Rep, 2020-02-10;10(1):2300. 2020-02-10 [PMID: 32042028] (Bioassay, Human)	Bioassay	Human
SM Garrett, E Hsu, JM Thomas, JM Pilewski, C Feghali-Bo Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions PLoS ONE, 2019-11-25;14(11):e0225422. 2019-11-25 [PMID: 31765403] (Bioassay, Human)	Bioassay	Human
C Fredolini, S Byström, L Sanchez-Ri, M Ioannou, D Tamburro, F Pontén, RM Branca, P Nilsson, J Lehtiö, JM Schwenk Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles Sci Rep, 2019-06-06;9(1):8324. 2019-06-06 [PMID: 31171813] (ELISA Capture, Human)	ELISA Capture	Human
CA Conover, LK Bale, RL Frye, HV Schaff Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes Physiol Rep, 2019-02-01;7(4):e14006. 2019-02-01 [PMID: 30809969] (Bioassay, Human)	Bioassay	Human
C De Giovann, P Nanni, L Landuzzi, ML Ianzano, G Nicoletti, S Croci, A Palladini, PL Lollini Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis BMC Cancer, 2019-02-07;19(1):126. 2019-02-07 [PMID: 30732578] (ELISA (Capture), Western Blot, Human)	ELISA (Capture), Western Blot	Human
Z Chen, J Liu, D Chu, Y Shan, G Ma, H Zhang, XD Zhang, P Wang, Q Chen, C Deng, W Chen, DS Dimitrov, Q Zhao A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells Int. J. Biol. Sci., 2018-05-21;14(7):799-806. 2018-05-21 [PMID: 29910690] (Library Screening, Human)	Library Screening	Human
R Sambathkum, R Akkerman, S Dastidar, P Roelandt, M Kumar, M Bajaj, AR Mestre Ros, N Helsen, V Vanslembro, E Kalo, S Khurana, J Laureys, C Gysemans, MM Faas, P de Vos, CM Verfaillie Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells PLoS ONE, 2018-05-11;13(5):e0197046. 2018-05-11 [PMID: 29750821] (Bioassay, Human)	Bioassay	Human
R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339495] (Bioassay)	Bioassay
SP Guan, ATL Lam, JP Newman, KLM Chua, CYL Kok, ST Chong, MLK Chua, PYP Lam Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2/IGFBP2 complex FEBS Open Bio, 2017-11-23;8(1):15-26. 2017-11-23 [PMID: 29321953] (Bioassay, Human)	Bioassay	Human
Y Liu, C Yu, Y Wu, X Sun, Q Su, C You, H Xin CD44(+) fibroblasts increases breast cancer cell survival and drug resistance via IGF2BP3-CD44-IGF2 signalling J. Cell. Mol. Med., 2017-05-18;0(0):. 2017-05-18 [PMID: 28523716] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
Amber N Stratman Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta Development, 2016-12-02;0(0):. 2016-12-02 [PMID: 27913637] (Bioassay, Human)	Bioassay	Human
Tong Wu TGF? signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells Mol. Carcinog., 2016-11-25;0(0):. 2016-11-25 [PMID: 27862334] (Bioassay, Human)	Bioassay	Human
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells Oncogene, 2016-08-22;0(0):. 2016-08-22 [PMID: 27546618] (Bioassay, Human)	Bioassay	Human
G Cassinelli, E Favini, L Dal Bo, M Tortoreto, M De Maglie, G Dagrada, S Pilotti, F Zunino, N Zaffaroni, C Lanzi Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases Oncotarget, 2016-07-26;7(30):47848-47863. 2016-07-26 [PMID: 27374103]
Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS Sci Rep, 2016-05-16;6(0):25960. 2016-05-16 [PMID: 27180807] (Bioassay, Human)	Bioassay	Human
Gomez D, O'Driscoll M, Sheets T, Hruban R, Oberholzer J, McGarrigle J, Shamblott M Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS ONE, 2015-08-19;10(8):e0133862. 2015-08-19 [PMID: 26288179] (Bioassay, Human)	Bioassay	Human
Shahmoradi A, Radyushkin K, Rossner M Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A, 2015-06-22;112(27):E3582-9. 2015-06-22 [PMID: 26100875] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest, 2015-02-09;125(3):1243-54. 2015-02-09 [PMID: 25664855] (Bioassay, Primate - Macaca nemestrina (Southern Pig-tailed Macaque))	Bioassay	Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
Crosley , Erin J, Dunk , Caroline, Beristain , Alexande, Christians , Julian K IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Reprod Biol Endocrinol, 2014-12-04;12(0):123. 2014-12-04 [PMID: 25475528] (Bioassay, Human)	Bioassay	Human
Bambah-Mukku D, Travaglia A, Chen D, Pollonini G, Alberini C A positive autoregulatory BDNF feedback loop via C/EBPbeta mediates hippocampal memory consolidation. J Neurosci, 2014-09-10;34(37):12547-59. 2014-09-10 [PMID: 25209292] (In Vivo, Rat)	In Vivo	Rat
Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. Br J Cancer, 2014-05-22;110(12):2865-73. 2014-05-22 [PMID: 24853185] (Bioassay, Human)	Bioassay	Human
Laggai S, Kessler S, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq I, Mueller R, Hartmann R, Haybaeck J, Kiemer A The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res, 2014-04-22;55(6):1087-1097. 2014-04-22 [PMID: 24755648] (Bioassay, Human)	Bioassay	Human
Yang G, Geng X, Song J, Wu Y, Yan H, Zhan Z, Yang L, He W, Liu Z, Qiu S, Liu Z, Yang P Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol, 2014-04-01;133(6):1702-8.e5. 2014-04-01 [PMID: 24698315] (Bioassay, Human)	Bioassay	Human
Cai , Qing, Bonfanti , Paola, Sambathkumar , Rangaraj, Vanuytsel , Kim, Vanhove , Jolien, Gysemans , Conny, Debiec-Rychter , Maria, Raitano , Susanna, Heimberg , Harry, Ordovas , Laura, Verfaillie , Catherin Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem Cells Transl Med, 2014-02-03;3(4):489-99. 2014-02-03 [PMID: 24493854] (Bioassay, Human)	Bioassay	Human
Kan S, Troitskaya L, Sinow C, Haitz K, Todd A, Di Stefano A, Le S, Dickson P, Tippin B Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of alpha-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts. Biochem J, 2014-03-01;458(2):281-9. 2014-03-01 [PMID: 24266751] (Bioassay, Human)	Bioassay	Human
Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. Leukemia, 2011-10-18;26(5):1001-11. 2011-10-18 [PMID: 22005787] (Bioassay, Human)	Bioassay	Human
Guillon-Munos A, Oikonomopoulou K, Michel N, Smith CR, Petit-Courty A, Canepa S, Reverdiau P, Heuzé-Vourc'h N, Diamandis EP, Courty Y Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors. J. Biol. Chem., 2011-05-31;286(29):25505-18. 2011-05-31 [PMID: 21628462] (Enzyme Assay Substrate)	Enzyme Assay Substrate
Fischer AJ, Scott MA, Zelinka C, Sherwood P A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia. Glia, 2010-04-15;58(6):633-49. 2010-04-15 [PMID: 19941335] (In Vivo, Chicken)	In Vivo	Chicken
Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis. Exp. Cell Res., 2009-09-19;315(19):3301-11. 2009-09-19 [PMID: 19769965] (Bioassay, Human)	Bioassay	Human
Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30. 2009-05-29 [PMID: 19482945] (Bioassay, Human)	Bioassay	Human
Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol. Cancer Ther., 2008-06-01;7(6):1483-93. 2008-06-01 [PMID: 18566219] (Bioassay, Human)	Bioassay	Human
Hsu E, Feghali-Bostwick CA Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways. Am. J. Pathol., 2008-05-08;172(6):1580-90. 2008-05-08 [PMID: 18467708] (Bioassay, Human)	Bioassay	Human
Adkins RM, Fain JN, Krushkal J Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. Pediatr. Res., 2007-10-01;62(4):451-5. 2007-10-01 [PMID: 17667841] (ELISA (Standard))	ELISA (Standard)
Spicer LJ, Aad PY Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol. Reprod., 2007-03-14;77(1):18-27. 2007-03-14 [PMID: 17360960] (Bioassay, Bovine)	Bioassay	Bovine
Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
McCaig C, Duval C, Hemers E, Steele I, Pritchard DM, Przemeck S, Dimaline R, Ahmed S, Bodger K, Kerrigan DD, Wang TC, Dockray GJ, Varro A The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology, 2006-03-06;130(6):1754-63. 2006-03-06 [PMID: 16697739] (Bioassay, Human)	Bioassay	Human
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, Asaka M, Ochiai A Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem. Biophys. Res. Commun., 2005-08-05;333(3):1011-6. 2005-08-05 [PMID: 15964556] (Bioassay, Human)	Bioassay	Human
Show All 48 Publications. Collapse Publications.

Array 292-G2

• IGF-II/IGF2 Antibodies
• IGF-II/IGF2 ELISA Kit
• IGF-II/IGF2 Lysates
• IGF-II/IGF2 Proteins
• IGF-II/IGF2 ELISAs
• IGF-II/IGF2 Proteins and Enzymes