Name: CXCL2/GRO beta/MIP-2/CINC-3 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-452-NA
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	IHC, B/N, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF452

Immunogen	E. coli-derived recombinant mouse CXCL2/MIP-2 Ala28-Asn100 Accession # P10889
Specificity	Detects mouse CXCL2/MIP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) GRO beta , recombinant mouse (rm) GRO gamma , rmKC and rmLIX is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	CXCL2
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

CXCL2/GRO beta/MIP-2/CINC-3 Antibody [Unconjugated]

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CXCL2/GRO beta/MIP-2/CINC-3 Antibody [Unconjugated] Summary

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Publications for CXCL2/GRO beta/MIP-2/CINC-3 Antibody (AF-452-NA)(29)

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Bioinformatics

Publications using AF-452-NA	Applications	Species
Chung, KP;Cheng, CN;Chen, YJ;Hsu, CL;Huang, YL;Hsieh, MS;Kuo, HC;Lin, YT;Juan, YH;Nakahira, K;Chen, YF;Liu, WL;Ruan, SY;Chien, JY;Plataki, M;Cloonan, SM;Carmeliet, P;Choi, AMK;Kuo, CH;Yu, CJ; Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation Nature communications 2024-08-22 [PMID: 39174557] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse
Bénard, A;Mittelstädt, A;Klösch, B;Glanz, K;Müller, J;Schoen, J;Nüse, B;Brunner, M;Naschberger, E;Stürzl, M;Mattner, J;Muñoz, LE;Sohn, K;Grützmann, R;Weber, GF; IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils Cell reports 2023-06-08 [PMID: 37300834] (In Vivo, Mouse)	In Vivo	Mouse
X Dong, Q Zhang, X Yu, D Wang, J Ma, J Ma, SH Shi Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex Nature Neuroscience, 2022-06-20;0(0):. 2022-06-20 [PMID: 35726058] (IHC, Mouse)	IHC	Mouse
MH Mursalin, PS Coburn, FC Miller, ET Livingston, R Astley, MC Callegan C-X-C Chemokines Influence Intraocular Inflammation During Bacillus Endophthalmitis Investigative Ophthalmology & Visual Science, 2021-11-01;62(14):14. 2021-11-01 [PMID: 34784411] (Neutralization, Mouse)	Neutralization	Mouse
RM Urbantat, C Jelgersma, S Brandenbur, M Nieminen-K, I Kremenetsk, J Zollfrank, S Mueller, K Rubarth, A Koch, P Vajkoczy, G Acker Tumor-Associated Microglia/Macrophages as a Predictor for Survival in Glioblastoma and Temozolomide-Induced Changes in CXCR2 Signaling with New Resistance Overcoming Strategy by Combination Therapy International Journal of Molecular Sciences, 2021-10-16;22(20):. 2021-10-16 [PMID: 34681839] (IHC, Mouse)	IHC	Mouse
Y Makino, K Fujikawa, M Matsuki-Fu, S Inoue, M Nakamura Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption Dentistry journal, 2021-01-12;9(1):. 2021-01-12 [PMID: 33445432] (IHC, Mouse)	IHC	Mouse
Min Song, Lu Chen, Lusha Zhang, Chunxiao Li, Joel Wake Coffie, Zhirui Fang et al. Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling Pharmaceutical Biology 9/2/2020 [PMID: 32870741]
K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice Dis Model Mech, 2019-11-12;0(0):. 2019-11-12 [PMID: 31562139] (IHC, Mouse)	IHC	Mouse
WL Hwang, HY Lan, WC Cheng, SC Huang, MH Yang Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer J Hematol Oncol, 2019-01-25;12(1):10. 1/25/2019 [PMID: 30683126]
Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot et al. Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis Immunity 12/18/2018 [PMID: 30446388]
J Zhou, J Li, Y Yu, Y Liu, H Li, Y Liu, J Wang, L Zhang, X Lu, Z Chen, D Zuo Mannan-binding lectin deficiency exacerbates sterile liver injury in mice through enhancing hepatic neutrophil recruitment J. Leukoc. Biol., 2018-10-23;0(0):. 2018-10-23 [PMID: 30351498] (Neutralization, Western Blot, Mouse)	Neutralization, Western Blot	Mouse
Pratik P. Vikhe, Tom Purnell, Steve D.M. Brown, Derek W. Hood Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear Cellular Microbiology 1/1/2019 [PMID: 30265765]
JS Stoolman, PC Duncker, AK Huber, DA Giles, JM Washnock-S, AM Soulika, BM Segal An IFN?/CXCL2 regulatory pathway determines lesion localization during EAE J Neuroinflammation, 2018-07-16;15(1):208. 2018-07-16 [PMID: 30012158] (IHC, Mouse)	IHC	Mouse
T Tsubaki, T Kadonosono, S Sakurai, T Shiozawa, T Goto, S Sakai, T Kuchimaru, T Sakamoto, H Watanabe, G Kondoh, S Kizaka-Kon Novel adherent CD11b+Gr-1+tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment Oncotarget, 2018-01-29;9(13):11209-11226. 2018-01-29 [PMID: 29541408] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Monoranjan Boro, Kithiganahalli Narayanaswamy Balaji CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2 The Journal of Immunology 9/1/2017 [PMID: 28739876]
Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shetty Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells American Journal of Physiology-Lung Cellular and Molecular Physiology 6/1/2017 [PMID: 28385810]
TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression Sci Rep, 2016-12-20;6(0):38684. 2016-12-20 [PMID: 27995997] (Bioassay, Mouse)	Bioassay	Mouse
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses Sci Rep, 2016-11-24;6(0):37695. 2016-11-24 [PMID: 27883091] (Neutralization, Mouse)	Neutralization	Mouse
Huebener , Peter, Pradere , Jean-Phi, Hernandez , Celine, Gwak , Geum-You, Caviglia , Jorge Ma, Mu , Xueru, Loike , John D, Jenkins , Rosalind, Antoine , Daniel J, Schwabe , Robert F The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest, 2014-12-22;125(2):539-50. 2014-12-22 [PMID: 25562324] (Neutralization, Mouse)	Neutralization	Mouse
Mizugishi K, Inoue T, Hatayama H, Bielawski J, Pierce J, Sato Y, Takaori-Kondo A, Konishi I, Yamashita K Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy. J Biol Chem, 2014-12-11;290(4):2053-68. 2014-12-11 [PMID: 25505239] (IHC, Mouse)	IHC	Mouse
Tatsuya Nagano, Hironori Edamatsu, Kazuyuki Kobayashi, Nobuyuki Takenaka, Masatsugu Yamamoto, Naoto Sasaki et al. Phospholipase C epsilon , an Effector of Ras and Rap Small GTPases, Is Required for Airway Inflammatory Response in a Mouse Model of Bronchial Asthma PLoS ONE 9/30/2014 [PMID: 25269075]
Stock A, Smith J, Carbone F Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection. J Exp Med, 2014-04-21;211(5):751-9. 2014-04-21 [PMID: 24752295] (ICC, Mouse)	ICC	Mouse
Baluk P, Phillips K, Yao L, Adams A, Nitschke M, McDonald D Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol, 2014-04-13;184(6):1877-89. 2014-04-13 [PMID: 24726646] (IHC, Mouse)	IHC	Mouse
Jablonska J, Wu C, Andzinski L, Leschner S, Weiss S CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-beta. Int J Cancer, 2013-10-31;134(6):1346-58. 2013-10-31 [PMID: 24154944] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. Infect. Immun., 2008-04-14;76(7):3001-10. 2008-04-14 [PMID: 18411294] (Functional Assay, IHC-Fr, Mouse)	Functional Assay, IHC-Fr	Mouse
Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, Singbartl K The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation. Crit. Care Med., 2007-09-01;35(9):2156-63. 2007-09-01 [PMID: 17855830] (Neutralization, Mouse)	Neutralization	Mouse
Cardona AE, Gonzalez PA, Teale JM CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response. Infect. Immun., 2003-05-01;71(5):2634-42. 2003-05-01 [PMID: 12704138] (ICC, Mouse)	ICC	Mouse
Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, Jung S, Littman DR, Ley K The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J. Clin. Invest., 2001-11-01;108(9):1307-14. 2001-11-01 [PMID: 11696575] (ICC, IHC-P, Mouse)	ICC, IHC-P	Mouse
Show All 29 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free AF-452-SP

Gene Symbol	CXCL2
Uniprot	P10889()