Name: CD3 Antibody (17A2) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB4841
Price: 479 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	Flow, IHC, IP, CyTOF-ready, Func, ICC/IF
Clone	17A2
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB4841U-100UG

Alexa Fluor 405 FAB4841V-025

Alexa Fluor 488 FAB4841G-025

Alexa Fluor 488 FAB4841G-100

Alexa Fluor 532 FAB4841X

Alexa Fluor 594 FAB4841T-100

Alexa Fluor 594 FAB4841T-025

Alexa Fluor 647 FAB4841R-100UG

Alexa Fluor 700 FAB4841N-100

Alexa Fluor 750 FAB4841S-025

Allophycocyanin FAB4841A-100

Allophycocyanin FAB4841A-025

Allophycocyanin/Cy7 FAB4841APCCY7

Biotin BAM4841

CoraFluor 1 FAB4841CL1

DyLight 350 FAB4841D

DyLight 405 FAB4841E

DyLight 488 FAB4841K

DyLight 550 FAB4841L

DyLight 594 FAB4841M

DyLight 650 FAB4841W

DyLight 680 FAB4841Y

DyLight 755 FAB4841Z

Fluorescein FAB4841F-025

Fluorescein FAB4841F-100

HRP FAB4841H

Janelia Fluor 525 FAB4841JF525

Janelia Fluor 549 FAB4841I

Janelia Fluor 585 FAB4841JF585

Janelia Fluor 635 FAB4841JF635

Janelia Fluor 646 FAB4841J

Janelia Fluor 669 FAB4841JF669

PE/Atto594 FAB4841PEATT594

PE/Cy5.5 FAB4841PECY55

PE/Cy7 FAB4841PECY7

PerCP (Peridinin-chlorophyll Protein Complex) FAB4841C-025

PerCP (Peridinin-chlorophyll Protein Complex) FAB4841C-100

Phycoerythrin FAB4841P-025

Phycoerythrin FAB4841P-100

mFluor Violet 450 SE FAB4841MFV450

mFluor Violet 500 SE FAB4841MFV500

mFluor Violet 610 SE FAB4841MFV610

Catalog# & Formulation	Size	Price
Carrier Free FAB4841G-025

Carrier Free MAB4841-500

Carrier Free FAB4841V-025

Carrier Free FAB4841S-025

Carrier Free MAB4841-SP

Carrier Free FAB4841T-100

Carrier Free FAB4841T-025

Carrier Free FAB4841P-025

Carrier Free FAB4841F-025

Carrier Free FAB4841R-100UG

Carrier Free FAB4841C-025

Carrier Free FAB4841A-025

Carrier Free FAB4841P-100

Carrier Free FAB4841N-100

Carrier Free FAB4841G-100

Carrier Free FAB4841F-100

Carrier Free FAB4841C-100

Carrier Free FAB4841A-100

Carrier Free FAB4841U-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB4841U-100UG
Alexa Fluor 405	FAB4841V-025
Alexa Fluor 488	FAB4841G-025
Alexa Fluor 488	FAB4841G-100
Alexa Fluor 532	FAB4841X
Alexa Fluor 594	FAB4841T-100
Alexa Fluor 594	FAB4841T-025
Alexa Fluor 647	FAB4841R-100UG
Alexa Fluor 700	FAB4841N-100
Alexa Fluor 750	FAB4841S-025
Allophycocyanin	FAB4841A-100
Allophycocyanin	FAB4841A-025
Allophycocyanin/Cy7	FAB4841APCCY7
Biotin	BAM4841
CoraFluor 1	FAB4841CL1
DyLight 350	FAB4841D
DyLight 405	FAB4841E
DyLight 488	FAB4841K
DyLight 550	FAB4841L
DyLight 594	FAB4841M
DyLight 650	FAB4841W
DyLight 680	FAB4841Y
DyLight 755	FAB4841Z
Fluorescein	FAB4841F-025
Fluorescein	FAB4841F-100
HRP	FAB4841H
Janelia Fluor 525	FAB4841JF525
Janelia Fluor 549	FAB4841I
Janelia Fluor 585	FAB4841JF585
Janelia Fluor 635	FAB4841JF635
Janelia Fluor 646	FAB4841J
Janelia Fluor 669	FAB4841JF669
PE/Atto594	FAB4841PEATT594
PE/Cy5.5	FAB4841PECY55
PE/Cy7	FAB4841PECY7
PerCP (Peridinin-chlorophyll Protein Complex)	FAB4841C-025
PerCP (Peridinin-chlorophyll Protein Complex)	FAB4841C-100
Phycoerythrin	FAB4841P-025
Phycoerythrin	FAB4841P-100
mFluor Violet 450 SE	FAB4841MFV450
mFluor Violet 500 SE	FAB4841MFV500
mFluor Violet 610 SE	FAB4841MFV610

CD3 Antibody (17A2) [Unconjugated]

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CD3 Antibody (17A2) [Unconjugated] Summary

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Publications for CD3 Antibody (MAB4841)(42)

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Immunogen	T cell hybridoma D1
Specificity	Reacts with mouse TCR-associated CD3 complex that occurs on thymocytes and mature T cells.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Rat
Gene	CD3E
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB4841	Applications	Species
Balakrishnan, B;Luckey, D;Wright, K;Davis, JM;Chen, J;Taneja, V; Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis Science advances 2023-09-01 [PMID: 37656793] (Flow Cytometry, Transgenic Mouse)	Flow Cytometry	Transgenic Mouse
O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Neutralization, Mouse)	Neutralization	Mouse
Marco Busnelli, Stefano Manzini, Alice Colombo, Elsa Franchi, Fabrizia Bonacina, Matteo Chiara et al. Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia Arteriosclerosis, Thrombosis, and Vascular Biology 2022-07-01 [PMID: 35587694]
Choong-kun Lee, Bo-Yoon Park, Taehee Jo, Cheol-Heum Park, Ju-Hee Kim, Kyu-Jin Chung et al. Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells Stem Cells Translational Medicine 2022-07-20 [PMID: 35579982]
JH Cha, LC Chan, YN Wang, YY Chu, CH Wang, HH Lee, W Xia, WC Shyu, SP Liu, J Yao, CW Chang, FR Cheng, J Liu, SO Lim, JL Hsu, WH Yang, GN Hortobagyi, C Lin, L Yang, D Yu, LB Jeng, MC Hung Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer The Journal of Biological Chemistry, 2022-03-10;0(0):101817. 2022-03-10 [PMID: 35278434] (IHC, Mouse)	IHC	Mouse
Chun-Chi Chou, Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang et al. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6R alpha to inhibit IL-6/ IL-6R alpha /gp130 hexameric signaling complex formation mAbs 12/31/2022 [PMID: 35133941]
Z Zhang, H Na, Q Gan, Q Tao, Y Alekseyev, J Hu, Z Yan, JB Yang, H Tian, S Zhu, Q Li, IM Rajab, JK Blusztajn, B Wolozin, A Emili, X Zhang, T Stein, LA Potempa, WQ Qiu Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell, 2021-10-23;0(0):e13501. 2021-10-23 [PMID: 34687487] (IF, Mouse)	IF	Mouse
Yutaka Matsubara (松原裕), Luis Gonzalez, Gathe Kiwan, Jia Liu (刘佳), John Langford, Mingjie Gao (高明杰) et al. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling Arteriosclerosis, Thrombosis, and Vascular Biology 2021-12-01 [PMID: 34670406]
Stephan A. Ramos, John J. Morton, Prabha Yadav, Brendan Reed, Sheila I. Alizadeh, Ali H. Shilleh et al. Generation of functional human thymic cells from induced pluripotent stem cells Journal of Allergy and Clinical Immunology 2022-02-01 [PMID: 34331993]
J Zhou, N Zhang, W Zhang, C Lu, F Xu The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation Cell & bioscience, 2021-05-12;11(1):84. 2021-05-12 [PMID: 33980319] (Neutralization, Mouse)	Neutralization	Mouse
D Li, J Peng, T Li, Y Liu, M Chen, X Shi Itgb3-integrin-deficient mice may not be a sufficientï¿½model for patients with Glanzmann thrombasthenia Molecular Medicine Reports, 2021-04-21;23(6):. 2021-04-21 [PMID: 33880575] (IHC, Mouse)	IHC	Mouse
Yutaka Matsubara (松原裕), Gathe Kiwan, Jia Liu (刘佳), Luis Gonzalez, John Langford, Mingjie Gao (高明杰) et al. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation Arteriosclerosis, Thrombosis, and Vascular Biology 2021-03-01 [PMID: 33472405]
Y Kim, S Gautam, KR Aseer, J Kim, P Chandrasek, CH Mazucanti, P Ghosh, JF O'Connell, ME Doyle, A Appleton, E Lehrmann, QR Liu, JM Egan Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-&kappaB signaling Cell Death & Disease, 2020-12-09;11(12):1044. 2020-12-09 [PMID: 33298885] (IHC, Mouse)	IHC	Mouse
Marisa A. Jeffries, Alison E. Obr, Kelly Urbanek, Sharyl L. Fyffe-Maricich, Teresa L. Wood Cnp Promoter-Driven Sustained ERK1/2 Activation Increases B-Cell Activation and Suppresses Experimental Autoimmune Encephalomyelitis ASN Neuro 2020-11-24 [PMID: 33228381]
C Alvarez, S Suliman, R Almarhoumi, ME Vega, C Rojas, G Monasterio, M Galindo, R Vernal, A Kantarci Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis Sci Rep, 2020-11-04;10(1):19018. 2020-11-04 [PMID: 33149125] (Functional Assay, Mouse)	Functional Assay	Mouse
Jassim, A H, Cavanaugh, M Et al. Transcorneal Electrical Stimulation Reduces Neurodegenerative Process in a Mouse Model of Glaucoma. Ann Biomed Eng 2/1/2021 [PMID: 32974756]
Xiaoyan Lan, Dorota A. Kedziorek, Chengyan Chu, Anna Jablonska, Shen Li, Mihoko Kai et al. Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockade OncoImmunology 2020-09-14 [PMID: 32923139]
J Chida, H Hara, K Uchiyama, E Takahashi, H Miyata, H Kosako, Y Tomioka, T Ito, H Horiuchi, H Matsuda, H Kido, S Sakaguchi Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice PLoS Pathog., 2020-08-26;16(8):e1008823. 2020-08-26 [PMID: 32845931] (Flow Cytometry, ICC, IHC, Neutralization, Mouse)	Flow Cytometry, ICC, IHC, Neutralization	Mouse
YP Xu, L Lv, Y Liu, MD Smith, WC Li, XM Tan, M Cheng, Z Li, M Bovino, J Aubé, Y Xiong Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy J. Clin. Invest., 2019-07-16;130(0):. 2019-07-16 [PMID: 31310587] (IHC-P, Mouse)	IHC-P	Mouse
L Wen, H Lu, Q Li, Q Li, S Wen, D Wang, X Wang, J Fang, J Cui, B Cheng, Z Wang Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis J. Exp. Clin. Cancer Res., 2019-07-10;38(1):299. 2019-07-10 [PMID: 31291983] (IHC-P, Mouse)	IHC-P	Mouse
Ya-Yuan Fu, Anastasiya Egorova, Catherine Sobieski, Jason Kuttiyara, Marco Calafiore, Shuichiro Takashima et al. T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation Immunity 2019-07-02 [PMID: 31278057]
Garber C, Soung A et al. T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses. Nat Neurosci 6/24/2019 [PMID: 31235930]
J Wu, J Gu, S Zhou, H Lu, Y Lu, L Lu, X Wang Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function J Immunol Res, 2018-08-07;2018(0):1605341. 2018-08-07 [PMID: 30159338] (Activation, Mouse)	Activation	Mouse
MR Deyhle, PS Hafen, J Parmley, CN Preece, M Robison, JR Sorensen, B Jackson, DL Eggett, CR Hancock, RD Hyldahl CXCL10 increases in human skeletal muscle following damage but is not necessary for muscle regeneration Physiol Rep, 2018-04-01;6(8):e13689. 2018-04-01 [PMID: 29696819] (IHC, Mouse)	IHC	Mouse
P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Nitrosative damage during retrovirus infection-induced neuropathic pain J Neuroinflammation, 2018-03-05;15(1):66. 2018-03-05 [PMID: 29506535] (IHC, Mouse)	IHC	Mouse
S Swirski, C Röger, A Pienkowska, C Ihlenburg, G Fischer, O May, M Vorm, M Owczarek-L, J Neidhardt A Novel C-Terminal Mutation in Gsdma3 (C+/H-) Leads to Alopecia and Corneal Inflammatory Response in Mice Invest. Ophthalmol. Vis. Sci., 2018-01-01;59(1):561-571. 2018-01-01 [PMID: 29372254] (IHC, Mouse)	IHC	Mouse
W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang Crucial role of OX40/OX40L signaling in a murine model of asthma Mol Med Rep, 2018-01-18;0(0):. 2018-01-18 [PMID: 29344664] (Functional Assay, Mouse)	Functional Assay	Mouse
X Fu, F Sun, F Wang, J Zhang, B Zheng, J Zhong, T Yue, X Zheng, JF Xu, CY Wang Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression Mediators Inflamm., 2017-09-19;2017(0):5706152. 2017-09-19 [PMID: 29056830] (Functional Assay, Mouse)	Functional Assay	Mouse
R Fischer, J Marsal, C Guttà, SA Eisler, N Peters, JR Bethea, K Pfizenmaie, RE Kontermann Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2 Sci Rep, 2017-07-26;7(1):6607. 2017-07-26 [PMID: 28747780] (Functional Assay, Human)	Functional Assay	Human
W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017-07-21;10(1):348. 2017-07-21 [PMID: 28732522] (Functional Assay, Mouse)	Functional Assay	Mouse
Marco Busnelli, Stefano Manzini, Mika Hilvo, Cinzia Parolini, Giulia S. Ganzetti, Federica Dellera et al. Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE−/− mice Scientific Reports 2017-03-14 [PMID: 28291223]
PG Makker, SS Duffy, JG Lees, CJ Perera, RS Tonkin, O Butovsky, SB Park, D Goldstein, G Moalem-Tay Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy PLoS ONE, 2017-01-26;12(1):e0170814. 2017-01-26 [PMID: 28125674] (IHC, Mouse)	IHC	Mouse
Selective suppression of the ? isoform of p38 MAPK rescues late-stage tau pathology Alzheimers Res Ther, 2016-12-15;8(1):54. 2016-12-15 [PMID: 27974048] (ICC, Mouse)	ICC	Mouse
David A Hildeman Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire J. Immunol., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852740] (Functional Assay, Mouse)	Functional Assay	Mouse
Ouyang M, White E, Ren H, Guo Q, Zhang I, Gao H, Yanyan S, Chen X, Weng Y, da Fonseca A, Shah S, Manuel E, Zhang L, Vonderfecht S, Alizadeh D, Berlin J, Badie B Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model. PLoS ONE, 2016-02-01;11(2):e0148139. 2016-02-01 [PMID: 26829221] (IHC, Mouse)	IHC	Mouse
Fan , Miaomiao, Zhang , Yijun, Huang , Zhuoqion, Liu , Jun, Guo , Xuemin, Zhang , Hui, Luo , Haihua Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif. PLoS ONE, 2014-09-24;9(9):e108253. 2014-09-24 [PMID: 25250958] (Functional Assay, Mouse)	Functional Assay	Mouse
Ahn , Bum Ju, Le , Hoang, Shin , Min Wook, Bae , Sung-Jin, Lee , Eun Ji, Wee , Hee-Jun, Cha , Jong-Ho, Lee , Hyo-Jong, Lee , Hye Shin, Kim , Jeong Hu, Kim , Chang-Ye, Seo , Ji Hae, Lo , Eng H, Jeon , Sejin, Lee , Mi-Ni, Oh , Goo Taeg, Yin , Guo Nan, Ryu , Ji-Kan, Suh , Jun-Kyu, Kim , Kyu-Won Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem, 2013-12-17;289(6):3328-38. 2013-12-17 [PMID: 24347169] (IHC, Mouse)	IHC	Mouse
Nakamura , Takahiro, Hamuro , Junji, Takaishi , Mikiro, Simmons , Szandor, Maruyama , Kazuichi, Zaffalon , Andrea, Bentley , Adam J, Kawasaki , Satoshi, Nagata-Takaoka , Maho, Fullwood , Nigel J, Itami , Satoshi, Sano , Shigetos, Ishii , Masaru, Barrandon , Yann, Kinoshita , Shigeru LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis. J Clin Invest, 2013-12-09;124(1):385-97. 2013-12-09 [PMID: 24316976] (IHC, Mouse)	IHC	Mouse
Xu C, Yu P, Han X, DU L, Gan J, Wang Y, Shi Y TGF-beta promotes immune responses in the presence of mesenchymal stem cells. J Immunol, 2013-11-29;192(1):103-9. 2013-11-29 [PMID: 24293629] (Functional Assay, Mouse)	Functional Assay	Mouse
Vang , Amanda G, Housley , William, Dong , Hongli, Basole , Chaitali, Ben-Sasson , Shlomo Z, Kream , Barbara, Epstein , Paul M, Clark , Robert B, Brocke , Stefan Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J, 2013-12-15;456(3):463-73. 2013-12-15 [PMID: 24007532] (Bioassay, Mouse)	Bioassay	Mouse
De Palma AM, Verbeken E, Van Aelst I, Van den Steen PE, Opdenakker G, Neyts J Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis. Virology, 2008-10-16;382(1):20-7. 2008-10-16 [PMID: 18929380] (IHC-P, Mouse)	IHC-P	Mouse
Nguyen P, Moisini I, Geiger TL Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function. Blood, 2003-08-28;102(13):4320-5. 2003-08-28 [PMID: 12946999] (Functional Assay, Mouse)	Functional Assay	Mouse
Show All 42 Publications. Collapse Publications.