Lck [p Tyr394] Antibody (755103)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lck (p56lck) is a 56 kDa cytosolic phosphoprotein within the Src family of non-receptor tyrosine kinases. The 509 amino acid (aa) human Lck contains an SH3 domain (aa 61-121), an SH2 domain (aa 127-224) and a protein kinase domain (aa 251-259). A short (363 aa) isoform contains alternate sequence starting at aa 348, while a 539 aa isoform contains inserted sequence after aa 321. Lck interacts with T cell CD4 and CD8 molecules and plays a pivotal role in regulating T cell activation. It can be overexpressed in cancers and functions as an oncogene. Y394 is the major site for autophosphorylation that enhances kinase activity, while Y505 is the major phosphorylation site for negative regulation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB7500	Applications	Species
Zevolini, F;Onnis, A;Khazen, R;Müller, S;Marotta, G;Valitutti, S;Finetti, F;Baldari, CT; Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics Journal of cell science 2023-12-12 [PMID: 38084966] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Ye, Y;Morita, S;Chang, JJ;Buckley, PM;Wilhelm, KB;DiMaio, D;Groves, JT;Barrera, FN; Allosteric inhibition of the T cell receptor by a designed membrane ligand eLife 2023-10-05 [PMID: 37796108] (Western Blot, Human)	Western Blot	Human
Dey, G;Bharti, R;Braley, C;Alluri, R;Esakov, E;Crean-Tate, K;McCrae, K;Joehlin-Price, A;Rose, PG;Lathia, J;Gong, Z;Reizes, O; LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer Journal of ovarian research 2023-06-27 [PMID: 37370140] (Western Blot, Human)	Western Blot	Human
Caner Saygin, Giorgia Giordano, Kathryn Shimamoto, Bart Eisfelder, Anika Thomas-Toth, Girish Venkataraman et al. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia Clinical Cancer Research 8/15/2023 [PMID: 37363966]
W Colon-Mora, A Baer, G Lamture, JT Stapleton, JW Fischer, N Bhattarai A short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity Gene Therapy, 2021-11-11;0(0):. 2021-11-11 [PMID: 34759330] (Western Blot, Human)	Western Blot	Human
KK Crean-Tate, C Braley, G Dey, E Esakov, C Saygin, A Trestan, DJ Silver, SM Turaga, EV Connor, R DeBernardo, CM Michener, PG Rose, J Lathia, O Reizes Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors Journal of ovarian research, 2021-04-22;14(1):55. 2021-04-22 [PMID: 33888137] (Western Blot, Human)	Western Blot	Human
JVS Ormonde, Z Li, C Stegen, J Madrenas TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK J. Immunol., 2018-10-29;0(0):. 2018-10-29 [PMID: 30373850] (Western Blot, Human)	Western Blot	Human
A Baer, W Colon-Mora, N Bhattarai Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways Sci Rep, 2018-07-19;8(1):10910. 2018-07-19 [PMID: 30026610] (Western Blot, Human)	Western Blot	Human
J Borlido, S Sakuma, M Raices, F Carrette, R Tinoco, LM Bradley, MA D'Angelo Nuclear pore complex-mediated modulation of TCR signaling is required for na�ve CD4+ T cell homeostasis Nat. Immunol., 2018-05-07;0(0):. 2018-05-07 [PMID: 29736031] (Western Blot, Mouse)	Western Blot	Mouse
N Bhattarai, JH McLinden, J Xiang, MM Mathahs, WN Schmidt, TM Kaufman, JT Stapleton Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo PLoS Pathog, 2017-02-24;13(2):e1006232. 2017-02-24 [PMID: 28235043] (Western Blot, Human)	Western Blot	Human
Clayton K, Haaland M, Douglas-Vail M, Mujib S, Chew G, Ndhlovu L, Ostrowski M T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol, 2013-12-13;192(2):782-91. 2013-12-13 [PMID: 24337741] (ICC, Human)	ICC	Human
Show All 11 Publications. Collapse Publications.

Array MAB7500

• Lck Antibodies
• Lck Lysates
• Lck Protein
• Lck Proteins and Enzyme