Western Blot: Bcl-2 related protein A1 Antibody [NBP1-76715] - Analysis of Bfl-1 in (A) human kidney and (B) human lung tissue lysate with Bfl-1 antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: Bcl-2 related protein A1 Antibody [NBP1-76715] - Mouse Kidney cells.
Immunohistochemistry-Paraffin: Bcl-2 related protein A1 Antibody [NBP1-76715] - Mouse kidney tissue with Bcl2A1 antibody at 10 ug/ml.
Western Blot: Bcl-2 related protein A1 Antibody [NBP1-76715] - Activation of signaling pathways by dandelion root extract. Western blots of proteins involved in programmed cell death and cell survival and inflammation. ...read more
Immunocytochemistry/ Immunofluorescence: Bcl-2 related protein A1 Antibody - BSA Free [NBP1-76715] - Immunofluorescence of Bcl-2 related protein A1 in Mouse Kidney tissue with Bcl-2 related protein A1 antibody at 20 ...read more
Immunohistochemistry: Bcl-2 related protein A1 Antibody - BSA Free [NBP1-76715] - Immunohistochemistry of Bcl-2 related protein A1 in mouse kidney tissue with Bcl-2 related protein A1 antibody at 10 u/mL.
Immunocytochemistry/ Immunofluorescence: Bcl-2 related protein A1 Antibody - BSA Free [NBP1-76715] - Immunofluorescence of Bcl-2 related protein A1 in Mouse Kidney tissue with Bcl-2 related protein A1 antibody at 20 ...read more
Immunohistochemistry: Bcl-2 related protein A1 Antibody - BSA Free [NBP1-76715] - Immunohistochemistry of Bcl-2 related protein A1 in mouse kidney tissue with Bcl-2 related protein A1 antibody at 10 u/mL.
Bcl-2 related protein A1 Antibody - BSA Free Summary
Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Bfl-1. The immunogen is located within the last 50 amino acids of Bfl-1. Amino Acid Squence: ENGFVKKFEPKSG
Specificity
At least two isoforms of Bfl-1 are known to exist; this antibody will only detect the larger isoform.
Predicted Species
Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BCL2A1
Purity
Peptide affinity purified
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20 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified
Alternate Names for Bcl-2 related protein A1 Antibody - BSA Free
ACC-1
ACC-2
Bcl-2 related protein A1
BCL2A1
Bcl2L5
Bcl2-L-5
BCL2L5HBPA1
Bcl-2-like protein 5
BCL2-related protein A1
Bfl-1
BFL1bcl-2-related protein A1
GRS
GRSbcl2-L-5
hematopoietic BCL2-related protein A1
Hemopoietic-specific early response protein
Protein BFL-1
Protein GRS
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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