AMPK alpha 1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic  alpha subunit and regulatory beta  and gamma  subunits. Each subunit exists as alternate isoforms ( alpha 1,  alpha 2, beta 1,  beta 2,  gamma 1,  gamma 2,  gamma 3), with all 12 combinations able to form complexes. The catalytic alpha  subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta . AMPK’s role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Bioassay, IHC, Immunohistochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using AF3197	Applications	Species
Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu et al. Empagliflozin Ameliorates Preeclampsia and Reduces Postpartum Susceptibility to Adriamycin in a Mouse Model Induced by Angiotensin Receptor Agonistic Autoantibodies Frontiers in Pharmacology 3/23/2022 [PMID: 35401209]
Darrell Eacret, Julia Noreck, Julie A. Blendy Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice Behavioural Brain Research 2/1/2022 [PMID: 34843742]
Darrell Eacret, Julia Noreck, Julie A. Blendy Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice Behavioural Brain Research 2022-02-01 [PMID: 34843742] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Ha‐Yeon Shin, Wookyeom Yang, Doo Byung Chay, Eun‐ju Lee, Joon‐Yong Chung, Hyun‐Soo Kim et al. Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma Molecular Oncology 4/1/2021 [PMID: 33331115]
W Yang, HY Shin, H Cho, JY Chung, EJ Lee, JH Kim, ES Kang TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels Cancers (Basel), 2020-05-22;12(5):. 2020-05-22 [PMID: 32456076] (Western Blot, Human)	Western Blot	Human
W Yang, X Zhou, HR Zimmermann, T Ma Brain-specific suppression of AMPKalpha2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2alpha phosphorylation Mol. Psychiatry, 2020-05-04;0(0):. 2020-05-04 [PMID: 32366952] (IHC, Mouse)	IHC	Mouse
HR Zimmermann, W Yang, NP Kasica, X Zhou, X Wang, BC Beckelman, J Lee, CM Furdui, CD Keene, T Ma Brain-specific repression of AMPKalpha1 alleviates pathophysiology in Alzheimer's model mice J. Clin. Invest., 2020-07-01;130(7):3511-3527. 2020-07-01 [PMID: 32213711] (IHC, Human, Mouse)	IHC	Human, Mouse
Lucas Sagrillo-Fagundes, Josianne Bienvenue-Pariseault, Cathy Vaillancourt Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells PLOS ONE 1/10/2019 [PMID: 30629581]
CH Shi, C Rubel, SE Soss, R Sanchez-Ho, S Zhang, SC Madrigal, S Ravi, H McDonough, RC Page, WJ Chazin, C Patterson, CY Mao, MS Willis, HY Luo, YS Li, DA Stevens, MB Tang, P Du, YH Wang, ZW Hu, YM Xu, JC Schisler Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16 PLoS Genet., 2018-09-17;14(9):e1007664. 2018-09-17 [PMID: 30222779] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Cha JH, Yang WH, Xia W et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Mol. Cell 8/16/2018 [PMID: 30118680]
ODK Maddocks, D Athineos, EC Cheung, P Lee, T Zhang, NJF van den Br, GM Mackay, CF Labuschagn, D Gay, F Kruiswijk, J Blagih, DF Vincent, KJ Campbell, F Ceteci, OJ Sansom, K Blyth, KH Vousden Modulating the therapeutic response of tumours to dietary serine and glycine starvation Nature, 2017-04-19;544(7650):372-376. 2017-04-19 [PMID: 28425994] (Western Blot, Mouse)	Western Blot	Mouse
Manon Domise AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo Sci Rep, 2016-05-27;6(0):26758. 2016-05-27 [PMID: 27230293] (IHC, Mouse)	IHC	Mouse
Jiang S, Park D, Stigler W, Creighton J, Ravi S, Darley-Usmar V, Zmijewski J Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis. J Biol Chem, 2013-07-29;288(36):26013-26. 2013-07-29 [PMID: 23897815] (Bioassay, Mouse)	Bioassay	Mouse
Komori T, Doi A, Nosaka T, Furuta H, Akamizu T, Kitamura T, Senba E, Morikawa Y Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons. J. Biol. Chem., 2012-04-23;287(24):19985-96. 2012-04-23 [PMID: 22528490] (Western Blot, Mouse)	Western Blot	Mouse
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	10/11/2019	View Summary Application Western Blot Sample Tested Endothelial Species Mouse Lot wmp041909a

Array AF3197

• AMPK alpha 1 Antibodies
• AMPK alpha 1 ELISA Kits
• AMPK alpha 1 Lysate
• AMPK alpha 1 Proteins
• AMPK alpha 1 ELISAs