Adiponectin/Acrp30 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimulated by insulin. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, Adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease (1-3). Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors (4-7). Mature human Adiponectin consists of a 60 amino acid (aa) N-terminal collagenous region and a 137 aa C-terminal C1q-like globular domain which can be cleaved by a leukocyte-derived elastase (8-9). Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. Adiponectin associates into trimers that may assemble into medium molecular weight (MMW) hexamers and then into > 300 kDa high molecular weight (HMW) oligomers (10-12). The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes (13). The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities (12, 14).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: IHC, IHC-P, Native SDS-PAGE, Neutralization, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using AF1065	Applications	Species
Tee, JH;Vijayakumar, U;Shanmugasundaram, M;Lam, TYW;Liao, W;Yang, Y;Wong, WSF;Ge, R; Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice Respiratory research 2023-11-06 [PMID: 37932719] (Neutralization, Human)	Neutralization	Human
B Hu, X Lv, H Chen, P Xue, B Gao, X Wang, G Zhen, JL Crane, D Pan, S Liu, S Ni, P Wu, W Su, X Liu, Z Ling, M Yang, R Deng, Y Li, L Wang, Y Zhang, M Wan, Z Shao, H Chen, W Yuan, X Cao Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones J. Clin. Invest., 2020-07-01;0(0):. 2020-07-01 [PMID: 32191640] (IHC, Mouse)	IHC	Mouse
Shunbun Kita, Shiro Fukuda, Norikazu Maeda, Iichiro Shimomura Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin eLife 10/24/2019 [PMID: 31647413]
FJ Ruiz-Ojeda, A Anguita-Ru, AI Rupérez, C Gomez-Llor, J Olza, R Vázquez-Co, M Gil-Campos, G Bueno, R Leis, R Cañete, LA Moreno, A Gil, CM Aguilera Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism Sci Rep, 2019-03-08;9(1):3979. 2019-03-08 [PMID: 30850679] (Western Blot, Human)	Western Blot	Human
Lijie Zhao, Tingli Sun, Lina Wang Chitosan oligosaccharide improves the therapeutic efficacy of sitagliptin for the therapy of Chinese elderly patients with type 2 diabetes mellitus Therapeutics and Clinical Risk Management 7/20/2017 [PMID: 28721055]
K Tang, C Zhang, Y Zhang, Y Zhang, R Zhuang, B Jin, Y Ma Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Disease Severity J Immunol Res, 2017-03-23;2017(0):6468097. 2017-03-23 [PMID: 28424792] (Western Blot, Human)	Western Blot	Human
FJ Ruiz-Ojeda, C Gomez-Llor, CM Aguilera, A Gil, AI Rupérez Impact of 3-Amino-1,2,4-Triazole (3-AT)-Derived Increase in Hydrogen Peroxide Levels on Inflammation and Metabolism in Human Differentiated Adipocytes PLoS ONE, 2016-03-29;11(3):e0152550. 2016-03-29 [PMID: 27023799] (Western Blot, Human)	Western Blot	Human
Michael A. Polewski, Maggie S. Burhans, Minghui Zhao, Ricki J. Colman, Dhanansayan Shanmuganayagam, Mary J. Lindstrom et al. Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys[S] Journal of Lipid Research 8/1/2015 [PMID: 26063458]
Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY. J Biol Chem, 2015-05-14;290(29):18216-26. 2015-05-14 [PMID: 25975268] (Western Blot, Mouse)	Western Blot	Mouse
von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, Korosoglou G, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A, Humpert PM Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes. Diabetes, 2009-06-09;58(9):2093-9. 2009-06-09 [PMID: 19509019] (Western Blot, Human)	Western Blot	Human
Miller M, Cho JY, Pham A, Ramsdell J, Broide DH Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J. Immunol., 2009-01-01;182(1):684-91. 2009-01-01 [PMID: 19109202] (IHC-P, Human)	IHC-P	Human
Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid. Clin. Chem., 2007-06-28;53(8):1541-4. 2007-06-28 [PMID: 17599956] (Native SDS-PAGE, Western Blot, Human)	Native SDS-PAGE, Western Blot	Human
Retnakaran R, Connelly PW, Maguire G, Sermer M, Zinman B, Hanley AJ Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. Diabet. Med., 2007-03-01;24(3):245-52. 2007-03-01 [PMID: 17305786] (Western Blot, Human)	Western Blot	Human
Iversen PO, Wiig H Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis. Clin. Cancer Res., 2005-10-01;11(19):6793-9. 2005-10-01 [PMID: 16203766] (Neutralization, Human)	Neutralization	Human
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-P	Human	01/05/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 21935928 Species Human

Array AF1065

• Adiponectin/Acrp30 Antibodies
• Adiponectin/Acrp30 ELISA Kits
• Adiponectin/Acrp30 Lysate
• Adiponectin/Acrp30 Proteins
• Adiponectin/Acrp30 Proteins and Enzymes
• Adiponectin/Acrp30 ELISAs