Ghrelin Antibody (883622)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

GHRL (Ghrelin/Obestatin Prepropeptide) is a 117 aa precursor peptide that is processed into two chains, Ghrelin (aa24-51) and Obestatin (aa76-98).  The 18 kDa prepropeptide is cleaved into proGhrelin, and then further processed into mature Ghrelin by prohormone convertases.  Mature Ghrelin is modified with an N-octanoyl group on serine 3 which is required for receptor binding.  Ghrelin and Obestatin are predominantly synthesized in the gastric mucosa.  Ghrelin plays a role in growth factor release and appetite suppression as well as many other functions in a variety of organs.  Obestatin is a putative hormone that has been suggested to have opposite effects on growth factor release and appetite as Ghrelin. 

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: ICC, IHC.

Showing Publications 1 - 9 of 9.

Publications using MAB8200	Applications	Species
McKimpson WM, Kuo T, Kitamoto T et al. FOXO1 Is Present in Stomach Epithelium and Determines Gastric Cell Distribution Gastro Hep Advances 9/19/2022 [PMID: 36117550]
Verena van der Heide, Sonia Jangra, Phillip Cohen, Raveen Rathnasinghe, Sadaf Aslam, Teresa Aydillo et al. Limited extent and consequences of pancreatic SARS-CoV-2 infection Cell Reports 3/1/2022 [PMID: 35247306]
XX Yu, WL Qiu, L Yang, YC Wang, MY He, D Wang, Y Zhang, LC Li, J Zhang, Y Wang, CR Xu Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans Cell Research, 2021-03-10;0(0):. 2021-03-10 [PMID: 33692492] (IHC, Mouse)	IHC	Mouse
L Ribeiro-Pa, AC Jarry, JB Cavin, A Willemetz, J Le Beyec, A Sannier, S Benadda, AL Pelletier, M Hourseau, T Léger, B Morlet, A Couvelard, Y Anini, S Msika, JP Marmuse, S Ledoux, M Le Gall, A Bado Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells Nature Communications, 2021-01-04;12(1):110. 2021-01-04 [PMID: 33397977] (IHC, Rat)	IHC	Rat
T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals Nat Commun, 2019-10-11;10(1):4647. 2019-10-11 [PMID: 31604927] (ICC, IHC, Human, Mouse)	ICC, IHC	Human, Mouse
Moin ASM, Montemurro C, Zeng K et al. Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas. Front Endocrinol (Lausanne) 1/9/2018 [PMID: 30687234]
R Azzarelli, S Rulands, S Nestorowa, J Davies, S Campinoti, S Gillotin, P Bonfanti, B Göttgens, M Huch, B Simons, A Philpott Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells Sci Rep, 2018-10-18;8(1):15374. 2018-10-18 [PMID: 30337647] (IHC, Mouse)	IHC	Mouse
Md Moin AS, Cory M, Ong A et al. Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes J Endocr Soc 5/1/2017 [PMID: 28782056]
P Rodnoi, M Rajkumar, ASM Moin, SK Georgia, AE Butler, S Dhawan Neuropeptide Y expression marks partially differentiated ? cells in mice and humans JCI Insight, 2017-06-15;2(12):. 2017-06-15 [PMID: 28614797] (IHC, Mouse)	IHC	Mouse

Array MAB8200

• Ghrelin Antibodies
• Ghrelin ELISA Kits
• Ghrelin ELISA