DNA Ligase III Antibody (1F3)

There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III gene product migrates as a 100kDa (a-form) protein in somatic tissues, is ubiquitously expressed and complexes with XRCC-1 and a 97kDa (beta-form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in the base excision repair pathway.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: B/N, WB.

Showing Publications 1 - 10 of 10.

Publications using NBP1-41190	Applications	Species
Ebert F, Weiss A, Bultemeyer M et al. Arsenicals affect base excision repair by several mechanisms. Mutat Res 2011 Oct [PMID: 21782832] (B/N, WB, Human)	B/N, WB	Human
Singh SK, Wu W, Zhang L et al. Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-Pk inhibitors. Int J Radiat Oncol Biol Phys 2011 Feb [PMID: 20950945] (B/N, WB, Human)	B/N, WB	Human
Asagoshi K, Liu Y, Masaoka A et al. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA Repair (Amst) 2010 Feb [PMID: 20006562] (B/N, WB, Human)	B/N, WB	Human
Guo Z, Zheng L, Dai H et al. Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res 2009 Jun [PMID: 19336415] (B/N, WB, Human)	B/N, WB	Human
Chen X, Zhong S, Zhu X et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res 2008 May [PMID: 18451142] (B/N, WB, Human)	B/N, WB	Human
Windhofer F, Wu W, Iliakis G. Low levels of DNA ligases III and IV sufficient for effective NHEJ. J Cell Physiol 2007 Nov [PMID: 17492771] (B/N, WB, Human)	B/N, WB	Human
Dong Z, ToPrimateinson AE. ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha. Nucleic Acids Res 2006 [PMID: 17040896] (B/N, WB, Human)	B/N, WB	Human
Wang H, Rosidi B, Perrault R et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res 2005 May [PMID: 15899791] (B/N, WB, Human)	B/N, WB	Human
Okano S, Lan L, ToPrimateinson AE et al. Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells. Nucleic Acids Res 2005 Jan [PMID: 15653642] (B/N, WB, Human)	B/N, WB	Human
Leppard JB, Dong Z, Mackey ZB et al. Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. Mol Cell Biol 2003 Aug [PMID: 12897160] (B/N, WB, Human)	B/N, WB	Human

Array NBP1-41190

• DNA Ligase III Antibodies
• DNA Ligase III Lysate