TLR8 Antibody (935166) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TLR8, also designated as CD288 (cluster of differentiation 288), is a member of the toll-like receptor (TLR) family. TLRs make up a family of pattern recognition receptors that play important roles in the innate immune response. Broad classes of pathogens (e.g. viruses, bacteria, and fungi) constitutively express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMPs). These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the larger IL-1 R/TLR superfamily. Human TLR8 is an endosomal receptor that recognizes single stranded RNA (ssRNA), and can recognize ssRNA viruses such as Influenza, Sendai, and Coxsackie B viruses. TLR8 binding to the viral RNA recruits MyD88 and leads to activation of the transcription factor NF-kB and an antiviral response.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.

Showing Publication 1 - 1 of 1.

Publication using MAB8999	Applications	Species
AK Chauhan Fc?RIIIa Signaling Modulates Endosomal TLR Responses in Human CD4(+) T Cells J. Immunol., 2017-05-12;0(0):. 2017-05-12 [PMID: 28500073] (ICC, Human)	ICC	Human

Array MAB8999

• TLR8 Antibodies
• TLR8 ELISA Kits
• TLR8 Lysate
• TLR8 Proteins