Rad9 Antibody

Rad9 (cell cycle checkpoint control protein RAD9A or hRAD9) is an evolutionarily conserved protein which serves multiple functions for preserving genomic integrity, and besides its role as intra-S/G2 checkpoint , it also implicates in homologous recombination repair, base excision repair and mismatch repair pathways. PRKCD mediated Rad9 phosphorylation is essential for the assembly of 9-1-1 cell-cycle checkpoint response complex which is recruited to DNA lesion upon damage by RFC (RAD17-replication factor C) clamp loader complex. Thereafter, Rad9 acts as sliding clamp platform on DNA for multiple proteins involved in LP-BER (long-patch base excision repair). 9-1-1 complex stimulates DNA polymerase beta activity/stability, and is necessary for the recruitment of RHNO1 to sites of DNA-DSBs that occurs during S phase of cell cycle. Moreover, Rad9 exerts 3'->5' double stranded DNA exonuclease activity, and it transactivate p53 target genes such as p21 and has been shown to induce apoptosis through its interaction with Bcl-2/Bcl-xL.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-193	Applications	Species
Wong R, Lenart N, Hill L et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Flow Cytometry Basics for the Non-Expert. 2018-11-09 [PMID: 30453020]
Warmerdam DO, Brinkman EK, Marteijn JA et al. UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway. J Cell Sci 2013-05-01 [PMID: 23447674] (WB, Human)	WB	Human
Medhurst AL, Warmerdam DO, Akerman I et al. ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage. J Cell Sci 2008-12-01 [PMID: 19020305] (ICC/IF, WB, Human)	ICC/IF, WB	Human

Array NB100-193

• Rad9 Antibodies
• Rad9 Lysate
• Rad9 Proteins