ATR Antibody (2B5) - Azide and BSA Free

Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Func, IP, KO, WB, Western Blot.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using NB100-308	Applications	Species
Uchida C, Niida H, Sakai S et al. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis Biochimica et biophysica acta. Molecular cell research 2023-05-17 [PMID: 37201767]
Zeng F, Parker K, Zhan Y et al. Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice ASN Neuro 2023-01-23 [PMID: 36683340] (Western Blot)	Western Blot
Chakraborty P, Hiom K DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination Nature communications 2021-07-05 [PMID: 34226554] (WB)	WB
Kim W, Zhao F, Wu R et al. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex Nat Commun 2019-11-22 [PMID: 31757956] (KO, WB, Mouse)	KO, WB	Mouse
Haro KJ, Sheth A, Scheinberg DA et al. Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells. PLoS One 2012-01-01 [PMID: 23155415] (WB, Human)	WB	Human
Oku T, Nakano M, Kaneko Y et al. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. J Biol Chem 2012-12-14 [PMID: 23100250] (Human)		Human
Ha K, Fiskus W, Rao R et al. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther 2011-07-01 [PMID: 21566061] (IP, Func, Human)	IP, Func	Human
Chen Y, Chen CF, Riley DJ et al. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle 2011-02-01 [PMID: 21301226] (Func, IP, Human)	Func, IP	Human
Zuco V, Benedetti V, Zunino F. ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Cancer Lett 2010-06-01 [PMID: 20042274] (IP, Func, Human)	IP, Func	Human
Cui B, Johnson SP, Bullock N et al. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol 2009-06-01 [PMID: 19261750] (Func, IP, Human)	Func, IP	Human
Katsuki Y, Nakada S, Yokoyama T et al. Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Cancer Sci 2008-08-01 [PMID: 18754864] (Func, IP, Human)	Func, IP	Human
Kulkarni A, Das KC. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Am J Physiol Lung Cell Mol Physiol 2008-05-01 [PMID: 18344416] (Func, IP, Human)	Func, IP	Human
Liu X, Matsuda A, Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther 2008-01-01 [PMID: 18202016] (Func, IP, Human)	Func, IP	Human
Manthey KC, Opiyo S, Glanzer JG et al. NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci 2007-12-01 [PMID: 18003706] (IP, Func, Human)	IP, Func	Human
Liu Y, Rusinol A, Sinensky M et al. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci 2006-11-01 [PMID: 17062639] (IP, Func, Human)	IP, Func	Human
Wu X, Shell SM, Liu Y et al. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene 2007-02-01 [PMID: 16862173] (Func, IP, Human)	Func, IP	Human
Tyagi, A et al. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis;27(11):2269-80. 2006-11-01 [PMID: 16777994]
Wu X, Shell SM, Yang Z et al. Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res 2006-03-01 [PMID: 16540648] (Func, IP, Human)	Func, IP	Human
Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res 2005-12-01 [PMID: 16322218] (IP, Func, Human)	IP, Func	Human
Horton JK, Stefanick DF, Naron JM et al. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. J Biol Chem 2005-04-01 [PMID: 15701627] (Func, IP, Human)	Func, IP	Human
Li J, Stern DF. Regulation of CHk2 by DNA-dependent protein kinase. J Biol Chem 2005-03-01 [PMID: 15668230] (Func, IP, Human)	Func, IP	Human
Show All 21 Publications. Collapse Publications.

Array NB100-308

• ATR Antibodies
• ATR Protein