Recombinant Human NOD1 GST (N-Term) Protein

This product is produced by and distributed for Abnova, a company based in Taiwan.

Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome, and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways, thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria, the induction of inflammatory responses, and the regulation of caspase activation and apoptosis. NOD1/CARD4 (caspase-recruitment domain 4 gene) is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006, and Inohara et al. 2003). NOD1 is expressed by cell types that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells, and epithelial cells (reviewed in Strober et al. 2006). NOD1 is thought to play a role in the pathogenesis of human gastrointestinal disease and is associated with inflammatory bowel diseases and asthma. It is involved in host defense against Helicobacter pylori infection of the gastric mucosa, a chronic infection that can lead to peptic ulcers and gastric cancer. This antibody recognizes NOD1/CARD4. Human NOD1/CARD4 is a 953 amino acid protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 4 of 4.

Publications using H00010392-P01	Applications	Species
Hara H, Seregin SS, Yang D et al. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018-10-26 [PMID: 30392956] (Human)		Human
Hong Tj, Hahn Js. Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli. Biochem. Biophys. Res. Commun. 2016-09-30 [PMID: 27591899]
Askari N, Correa RG, Zhai D et al. Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member. J Biotechnol 2012-01-01 [PMID: 22062585]
Laroui H, Yan Y, Narui Y et al. L-Ala-{gamma}-D-Glu-meso-diaminopimelic Acid (DAP) Interacts Directly with Leucine-rich Region Domain of Nucleotide-binding Oligomerization Domain 1, Increasing Phosphorylation Activity of Receptor-interacting Serine/Threonine-protein Kinase 2 and Its Interaction with Nucleotide-binding Oligomerization Domain 1. J Biol Chem;286(35):31003-31013. 2011-09-02 [PMID: 21757725]

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	WB	Human	06/21/2010	View Summary Application Western Blot Sample Tested purified protein, Sample Amount: 1ug Species Human Lot 0990427

Array H00010392-P01

• NOD1 Antibodies
• NOD1 Lysate
• NOD1 Proteins