Mre11 Antibody

Mre11 (double-strand break repair protein MRE11A) is an important component of MRN/X complex (Mre11, Rad50, and Nbs1/Xrs2), playing a central role in double-strand break (DSB) repair, DNA recombination, telomere integrity maintenance, meiotic cell division, and viral infection. Mre11 and Rad50 comprise the catalytic component of the MRN complex with Rad50 involved in ATP hydrolysis and Mre11 functioning as a nuclease having both single-strand endonuclease and double-strand-specific 3'-5' exonuclease activity (1). The MRN complex is also involved in DNA damage signaling via activation of ATM kinase and in telomeres, where it may modulate t-loop formation (2). In addition, Mre11 is a component of the BASC complex (BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN) and interacts with DCLRE1C/Artemis as well as DCLRE1B/Apollo (3).

The MRN assembles as a hetero-hexamer consisting of 2 RAD50 subunits, 2 MRE11 nucleases, and 2 NBS1 subunits, specific to eukaryotes. Mre11 is highly conserved with the N-terminal region of the human protein sharing approximately 50% amino acid sequence identity with the yeast ortholog. Human Mre11 has 3 known isoforms with the predominant isoform having a theoretical molecular weight of 80.6kDa. This nuclear localized protein has high expression in proliferating tissues. Defects in Mre11 can lead to genomic instability, telomere shortening, aberrant meiosis, hypersensitivity to DNA damage, and ataxia telangiectasia-like disorder (ATLD). MRN expression has been associated with the prognosis of cancer and MRN mutants have been linked to cancer susceptibility in ovarian cancer and glioma (4, 5).

References

1. Paull TT. (2018) 20 Years of Mre11 Biology: No End in Sight. Mol Cell. 71(3):419-427. PMID: 30057197

2. Syed A, Tainer JA. (2018) The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. Annu Rev Biochem. 87:263-294. PMID: 29709199

3. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14(8):927-39. PMID: 10783165

4. Kim JH, Grosbart M, Anand R, Wyman C, Cejka P, Petrini JHJ. (2017) The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep. 18(2):496-507. PMID: 28076792

5. Bian L, Meng Y, Zhang M, Li D. (2019) MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment. Mol Cancer. 18(1):169. PMID: 31767017

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Chicken, Hamster, Virus.

We have publications tested in 17 applications: B/N, ChIP-SEQ, ChIP-Seq, Chemotaxis, Chip Cytometry, FLOW, IB, ICC/IF, IF/IHC, IHC-Fr, IHC-P, IP, In Vivo, KD, Knockout Validated, PLA, WB.

Showing Publications 1 - 10 of 234. Show All 234 Publications. Collapse Publications.

Publications using NB100-142	Applications	Species
Rubio-Contreras D, Gómez-Herreros F TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription Nature communications 2023-11-09 [PMID: 37945566] (WB)	WB
Ip W-H, Tatham MH, Krohne S et al. Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors Journal of virology 2023-11-30 [PMID: 37916833] (WB, Human) Details: 1:5000 WB dilution	WB	Human
Herrera LR, Johnson RA, McGlynn K et al. The Cancer Testes Antigen, HORMAD1, Limits Genomic Instability in Cancer Cells by Protecting Stalled Replication Forks The Journal of biological chemistry 2023-10-12 [PMID: 37838177] (KD, WB, Human)	KD, WB	Human
Park SH, Kim N, Kang N et al. Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination Nucleic acids research 2023-09-22 [PMID: 37739427] (PLA, Human)	PLA	Human
Deshpande RA, Marin-Gonzalez A, Barnes HK et al. Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice Nat Commun 2023-09-16 [PMID: 37717054] (B/N)	B/N
Einig E, Jin C, Andrioletti V et al. RNAPII-dependent ATM signaling at collisions with replication forks Nature Communications 2023-08-24 [PMID: 37620345]
Liu C, Wang L, Li Y et al. RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis Nucleic acids research 2023-06-28 [PMID: 37378420]
Sachsenweger J, Jansche R, Merk T et al. ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients Cell death & disease 2023-05-17 [PMID: 37198153] (ICC/IF, PLA)	ICC/IF, PLA
Göttig L, Wei beta C, Stubbe M et al. Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression mBio 2023-05-08 [PMID: 37154747] (WB, Human)	WB	Human
Zou RS, Liu Y, Gaido OER et al. Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq Nature Methods 2023-05-01 [PMID: 37024653] (IP)	IP
Pollina EA, Gilliam DT, Landau AT et al. A NPAS4-NuA4 complex couples synaptic activity to DNA repair Nature 2023-02-01 [PMID: 36792830] (In Vivo, Mouse) Details: CUT&RUN	In Vivo	Mouse
Herrera LR, McGlynn K, Gibbs ZA et al. The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection Factor bioRxiv : the preprint server for biology 2023-02-03 [PMID: 36778501]
Lazarchuk P, Nguyen VN, Brunon S et al. Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells Frontiers in Molecular Biosciences 2023-01-12 [PMID: 36710880] (WB)	WB
Jeong H, Wie M, Baek IJ et al. TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11 Cells 2022-12-16 [PMID: 36552858] (WB, Human) Details: Dilution used in WB 1:2000	WB	Human
Wang L, Liu C, Wei H et al. Testis electroporation coupled with autophagy inhibitor to treat non-obstructive azoospermia Molecular therapy. Nucleic acids 2022-12-13 [PMID: 36420210] (ICC/IF, Mouse)	ICC/IF	Mouse
Price AM, Steinbock RT, Lauman R et al. Novel viral splicing events and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts PLOS Pathogens 2022-09-12 [PMID: 36095031] (WB)	WB
Qi L, Chakravarthy R, Li M et al. Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop iScience 2022-09-01 [PMID: 36065181] (ICC/IF, Mouse)	ICC/IF	Mouse
MOller L, Aird EJ, SchrOder MS et al. Recursive Editing improves homology-directed repair through retargeting of undesired outcomes Nature communications 2022-08-05 [PMID: 35931681] (Chip Cytometry) Details: 10?uL	Chip Cytometry
Zhang H, Xiong Y, Su D et al. TDP1-independent pathways in the process and repair of TOP1-induced DNA damage Nature communications 2022-07-22 [PMID: 35869071] (WB, Human) Details: Dilution: 1:1000	WB	Human
Fowler FC, Chen BR, Zolnerowich N et al. DNA-PK promotes DNA end resection at DNA double strand breaks in G(0) cells eLife 2022-05-16 [PMID: 35575473] (WB)	WB
Chakraborty S, Singh M, Pandita R et al. Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks iScience 2022-03-01 [PMID: 35434547]
Gnedina O, Morshneva A, Skvortsova E, Igotti M HDAC Inhibitor Sodium Butyrate Attenuates the DNA Repair in Transformed but Not in Normal Fibroblasts International Journal of Molecular Sciences 2022-03-23 [PMID: 35408878] (WB, Mouse)	WB	Mouse
Zhang C, Zhou B, Gu F et al. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation Molecular cell 2022-02-17 [PMID: 35219381]
Ding M, Qing X, Zhang G et al. The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons Frontiers in Aging Neuroscience 2022-01-28 [PMID: 35153719] (ICC/IF, IHC-Fr)	ICC/IF, IHC-Fr
Chen C, Bridge E DNA-PK phosphorylation at Ser2056 during adenovirus E4 mutant infection is promoted by viral DNA replication and independent of the MRN complex Virology 2021-11-01 [PMID: 34768112] (ICC/IF, Human)	ICC/IF	Human
Mirzaei R, Gordon A, Zemp FJ Et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NF kappa B pathway Science advances 2021-11-05 [PMID: 34739319] (WB, Mouse)	WB	Mouse
Graziano S, Coll-Bonfill N, Teodoro-Castro B Et al. Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability The Journal of biological chemistry 2021-10-11 [PMID: 34648766] (WB)	WB
Paiano J, Zolnerowich N, Wu W et al. Role of 53BP1 in end protection and DNA synthesis at DNA breaks Genes & development 2021-10-01 [PMID: 34503990] (Chemotaxis)	Chemotaxis
Chen BR, Wang Y, Tubbs A et al. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells eLife 2021-09-03 [PMID: 34477552] (WB)	WB
Kaul Z, Cheung CTY, Bhargava P Et al. Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells Scientific reports 2021-08-23 [PMID: 34426596] (WB, Human)	WB	Human
Wang J, Liu R, Wang Y Et Al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression J Cancer 2021-08-02 [PMID: 34335948] (WB, ICC/IF)	WB, ICC/IF
Wu X, Wang B Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage Nature communications 2021-07-16 [PMID: 34272385]
Chakraborty P, Hiom K DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination Nature communications 2021-07-05 [PMID: 34226554] (WB)	WB
Liu C, Liu H, Zhang H et al. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans The EMBO journal 2021-05-12 [PMID: 33978233]
Mukherjee J, Pandita A, Kamalakar C et al. A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells Science translational medicine 2021-05-05 [PMID: 33952676]
Cabral JM, Cushman CH, Sodroski CN, Knipe DM ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection PLoS pathogens 2021-04-01 [PMID: 33909709]
Schep R, Brinkman EK, Leemans C et al. Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance Molecular cell 2021-04-06 [PMID: 33848455] (Chemotaxis, Human)	Chemotaxis	Human
VanCevska A, Pfeiffer V, Feretzaki M, Ahmed W SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres bioRxiv (WB, Knockout Validated, Human)	WB, Knockout Validated	Human
Somyajit K, Spies J, Coscia F et al. Homology-directed repair protects the replicating genome from metabolic assaults Developmental cell 2021-02-22 [PMID: 33621493]
Guo Y, Gabola M, Lattanzio R et al. Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer bioRxiv (ICC/IF, Mouse)	ICC/IF	Mouse
Zou RS, Liu Y, Wu B, Ha T Cas9 deactivation with photocleavable guide RNAs Molecular cell 2021-04-01 [PMID: 33662274]
Mertens ME, Knipe DM Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses mBio 2021-02-09 [PMID: 33563816]
Dar AA, Sawada K, Dybas JM et al. The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA PLoS biology 2021-02-01 [PMID: 33524014] (WB, Mouse)	WB	Mouse
Zhou ZW, Kirtay M, Schneble N et al. NBS1 interacts with Notch signaling in neuronal homeostasis Nucleic Acids Res 2020-10-03 [PMID: 33010171] (IP, WB, Mouse)	IP, WB	Mouse
Lan W, Santofimia-CastaNo P, Swayden M et al. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents JCI Insight 2020-08-11 [PMID: 32780723] (WB, PLA, Human)	WB, PLA	Human
Volcic M, Sparrer KMJ, Koepke L et al. Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1 Nat Microbiol 2020-07-20 [PMID: 32690953] (WB, Human)	WB	Human
Herrmann, C, Dybas, J M Et al. Adenovirus-mediated ubiquitination alters protein-RNA binding and aids viral RNA processing. Nat Microbiol 2020-10-01 [PMID: 32661314] (WB, Human)	WB	Human
Rainey MD, Quinlan A, Cazzaniga C et al. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage EMBO Rep. 2020-06-04 [PMID: 32496651]
Hofmann S, Mai J, Masser S et Al. ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity Adv. Sci. 2020-02-27 [PMID: 32328411] (WB)	WB
Wienert B, Wyman S, Yeh C et al. CRISPR off-target detection with DISCOVER-seq Nat Protoc. 2020-04-20 [PMID: 32313254] (Chemotaxis, Human, Mouse)	Chemotaxis	Human, Mouse
Qi F, Meng Q, Hayashi I, Kobayashi J FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses J. Radiat. Res. 2020-03-25 [PMID: 32211858] (IP, WB, ICC/IF, Human)	IP, WB, ICC/IF	Human
Vancevska, A, Ahmed, W Et al. SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres. EMBO J 2020-04-01 [PMID: 32080884] (IF/IHC, Mouse)	IF/IHC	Mouse
Paiano J, Wu W et al. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nat Commun 2020-12-02 [PMID: 32051414] (Chemotaxis, Mouse)	Chemotaxis	Mouse
Pan X, Chen Y, Biju B et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops Sci Rep 2019-12-13 [PMID: 31836759] (WB, Human)	WB	Human
Mladenov E, Staudt C, Soni A et al. Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52 Nucleic Acids Res. 2019-12-13 [PMID: 31832684] (WB, Human)	WB	Human
Hanlon KS, Meltzer JC, Buzhdygan T et al. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression Mol Ther Methods Clin Dev 2019-12-13 [PMID: 31788496]
Scherthan H, Lee JH, Maus E et al. Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223 Cancers (Basel) 2019-11-26 [PMID: 31779276] (ICC/IF, Human)	ICC/IF	Human
Porebski B, Wild S, Kummer S, et al. WRNIP1 Protects Reversed DNA Replication Forks from SLX4-Dependent Nucleolytic Cleavage iScience 2019-11-22 [PMID: 31654852] (WB, Human)	WB	Human
Paiano J, Wu W, Yamada S, et al. ATM and PRDM9 Regulate SPO11-bound Recombination Intermediates During Meiosis bioRxiv Dec 18 2019 (ChIP-SEQ, Mouse)	ChIP-SEQ	Mouse
Herrmann C, Dybas J, Liddle J et al. Viral-mediated ubiquitination impacts interactions of host proteins with viral RNA and promotes viral RNA processing bioRxiv 2020-06-06 (WB, Human)	WB	Human
Weib CC Apobec3A is a novel restriction factor antagonizing efficient HAdV replication Thesis 2019-01-01 (WB, Virus)	WB	Virus
Cabral JM ATRX Mediated Restriction of Herpes Simplex Virus 1 Thesis (ICC/IF, Human)	ICC/IF	Human
Fievet A, Bellanger D, Zahed L et al. DNA repair functional analyses of NBN hypomorphic variants associated with NBN-related infertility Hum Mutat. 2019-11-15 [PMID: 31729086] (WB, Human)	WB	Human
Bai Y, Wang W, Li S et al. C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex Mol. Cell 2019-07-09 [PMID: 31353207]
Yoshimura Y Increased error-free DNA repair gene expression through reprogramming in human iPS cells Regenerative Therapy 2019-06-28 [PMID: 31304203] (WB, Human)	WB	Human
Velichko AK, Petrova NV, Luzhin AV et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription Nucleic Acids Res. 2019-05-22 [PMID: 31114877] (Chemotaxis, Mouse, Human)	Chemotaxis	Mouse, Human
Afzal S, Garg S, Ishida Y et al. Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin Mar Drugs. 2019-03-22 [PMID: 30909572] (WB, Rat)	WB	Rat
Alfano L, Caporaso A, Altieri A et al. Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation Nucleic Acids Res. 2019-02-25 [PMID: 30799487] (WB, Human)	WB	Human
Li CG, Mahon C, Sweeney NM et al. PPARg Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis Cell Rep 2019-01-29 [PMID: 30699358] (WB, Human)	WB	Human
Jachimowicz RD, Beleggia F, Isensee J et al. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors Cell 2019-01-24 [PMID: 30612738] (ICC/IF, Human)	ICC/IF	Human
Gustafsson NMS, Farnegardh K, Bonagas N et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun 2018-09-24 [PMID: 30250201] (Human)		Human
Hung PJ, Johnson B, Chen BR et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol. Cell. 2018-07-19 [PMID: 30017584] (WB, Mouse)	WB	Mouse
Muncheberg S, Hay RT, Ip WH et al. E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression. J Virol 2018-04-25 [PMID: 29695423] (Human)		Human
Vadnais C, Chen R, Fraszczak J et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun 2018-04-12 [PMID: 29651020] (ICC/IF, Human)	ICC/IF	Human
Pancholi NJ, Weitzman MD. Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex. Virology 2018-05-01 [PMID: 29547809]
Zhou H, Kawamura K, Yanagihara H et al. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein J Radiat Res. 2017-03-22 [PMID: 28369484] (WB, Human) Details: The regulatory mechanisms of the MRN complex, formed by NBS1 with MRE11 and RAD50, are investigated through immunoprecipitation.	WB	Human
Morales AJ, Carrero JA, Hung PJ et al. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife 2017-03-31 [PMID: 28362262] (WB)	WB
Gong Y, Handa N, Kowalczykowski SC, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR Genes Dev 2017-01-01 [PMID: 28115467] (IB, Mouse)	IB	Mouse
Speiseder T, Hofmann-Sieber H, Rodriguez E et al. Efficient transformation of primary human mesenchymal stromal cells by adenovirus early region 1 oncogenes. J. Virol. 2016-10-19 [PMID: 27795433] (WB, Human)	WB	Human
Cirilli M, Bereshchenko O, Ermakova O, Nerlov C Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Biochim. Biophys. Acta 2016-10-14 [PMID: 27746211] (WB, Mouse)	WB	Mouse
Xu Z, Song Z, Li G et al. H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Nucleic Acids Res 2016-07-18 [PMID: 27431324]
Hampp S, Kiessling T, Buechle K et al. DNA damage tolerance pathway involving DNA polymerase L and the tumor suppressor p53 regulates DNA replication fork progression Proc. Natl. Acad. Sci. U.S.A. 2016-07-26 [PMID: 27407148] (WB)	WB
Choi YE, Meghani K, Brault ME et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016-01-26 [PMID: 26774475] (ICC/IF, Human) Details: RPA2 antibody (clone 9H8) was used for ICC/IF analysis of RPE1 Fucci cells which were transfected with control ANT or miR-622 ANT and irradiated with 5 Gy IR for 4 hours (Figure 5).	ICC/IF	Human
Mayer A, Baran V, Sakakibara Y et al. DNA damage response during mouse oocyte maturation. Cell Cycle. 2016-01-08 [PMID: 26745237] (ICC/IF, Human)	ICC/IF	Human
Obermeier K, Sachsenweger J, Friedl TW et al. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2015-12-07 [PMID: 26640152] (WB, Human)	WB	Human
Burck C, Mund A, Berscheminski J et al. KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol 2015-11-04 [PMID: 26537675] (Human)		Human
Liu XS, Chandramouly G, Rass E et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun 2015-01-01 [PMID: 26446488] (IF/IHC)	IF/IHC
Iannascoli C, Palermo V, Murfuni I et al. The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation. Nucleic Acids Res. 2015-08-14 [PMID: 26275776] (WB, Human)	WB	Human
Kijas AW, Lim YC, Bolderson E et al. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015-08-03 [PMID: 26240375] (IP, Human)	IP	Human
Lee KY, Im JS, Shibata E et al. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun. 2015-07-28 [PMID: 26215093] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Muraki K, Han L, Miller D, Murnane JP et al. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks Nucleic Acids Res. 2015-07-23 [PMID: 26209132] (WB, Human)	WB	Human
Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem 2015-07-24 [PMID: 26055704] (Human)		Human
Kobayashi J, Saito Y, Okui M, Miwa N. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2015-03-18 [PMID: 25868131] (WB, Human)	WB	Human
Wimmer P, Berscheminski J, Blanchette P et al. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2015-03-16 [PMID: 25772236] (WB, Human)	WB	Human
Thangavel S, Berti M, Levikova M et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol 2015-03-02 [PMID: 25733713] (Human)		Human
Patel JP, Puck JM, Srinivasan R et al. Nijmegen Breakage Syndrome Detected by Newborn Screening for T Cell Receptor Excision Circles (TRECs) J. Clin. Immunol. 2015-02-13 [PMID: 25677497] (WB, Human)	WB	Human
Kondratova A, Watanabe T, Marotta M et al. Replication fork integrity and intra-S phase checkpoint suppress gene amplification. Nucleic Acids Res 2015-02-11 [PMID: 25672394] (WB, Hamster) Details: Using the DyLight 488 conjugated version of NB100-904, catalog number NB100-904G.	WB	Hamster
Parameswaran B, Chiang HC, Lu Y et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection Cell Cycle. 2015-02-01 [PMID: 25659039] (ICC/IF, Mouse) Details: Rabbit anti-Mre11 antibody used for ICC-IF application at 1:200 dilution on MEFs from wild type Brca1+/+ and Brca1-S971A/S971A mice (Figure 2A).	ICC/IF	Mouse
Badie S, Carlos AR, Folio C et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J 2015-02-03 [PMID: 25582120] (WB, Mouse)	WB	Mouse
Porro A, Feuerhahn S, Delafontaine J et al. Functional characterization of the TERRA transcriptome at damaged telomeres Nat Commun et al. 2014-10-31 [PMID: 25359189] (WB, Human) Details: nBS1 antibody used for WB analysis to evaluate the knockdown efficiency of endogenous nBS1 in HeLa cells (treated with shEV or shnBS1). The WB data is shown in Figure 4a.	WB	Human
Zou XH, Li WJ, Guo XJ et al. Inefficient export of viral late mRNA contributes to fastidiousness of human adenovirus type 41 (HAdV-41) in 293 cells. Virology. 2014-09-18 [PMID: 25240325]
Qin Q, Xie H, Wise SS et al. Homologous Recombination Repair Signaling in Chemical Carcinogenesis: Prolonged Particulate Hexavalent Chromium Exposure Suppresses the Rad51 Response in Human Lung Cells. Toxicol. Sci. 2014-08-30 [PMID: 25173789] (WB, Human)	WB	Human
Silva Barbara Alcaraz, Stambaugh Jessica R, Yokomori Kyoko et al. DNA damage to a single chromosome end delays anaphase onset. J Biol Chem. 2014-08-15 [PMID: 24982423] (ICC/IF)	ICC/IF
Illuzzi Giuditta, Fouquerel Elise, Ame Jean-Christophe et al. PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress. Nucleic Acids Res. 2014-06-06 [PMID: 24906880] (WB, Human)	WB	Human
Gao M, Wei W, Li MM et al. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Res 2014-05-01 [PMID: 24662483] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Ohara M, Funyu Y, Ebara S et al. Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination. J. Radiat. Res. 2014-03-09 [PMID: 24614819] (ICC/IF, Human)	ICC/IF	Human
Porro A, Feuerhahn S et al. TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep 2014-02-27 [PMID: 24529708] (WB, Human)	WB	Human
Gilliam DT Synaptic Activity Couples Inducible Transcription to Genome Preservation in the Mammalian Brain Thesis 2023-01-01 (Mouse)		Mouse
Lamkowski Andreas, Forcheron Fabien, Agay Diane et al. DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation. PLoS One. 2014-02-03 [PMID: 24498326]
Gilson T, Cheng CY, Hur WS, Branton PE. Analysis of the cullin binding sites of the e4orf6 proteins of human adenovirus e3 ubiquitin ligases. J. Virol. 2014-03-05 [PMID: 24453364] (WB, Human)	WB	Human
Wang Y, Hong Y, Li M et al. Mutation Inactivation of Nijmegen Breakage Syndrome Gene (NBS1) in Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. PLoS One 2013-12-13 [PMID: 24349281] (ICC/IF, IHC-Fr, Human)	ICC/IF, IHC-Fr	Human
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Wang Y, Cortez D, Yazdi P et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 2000-04-01 [PMID: 10783165] (IP, ICC/IF, WB, Human)	IP, ICC/IF, WB	Human
Brown, ML et al. Metabolism of recombination coding ends in scid cells. J Immunol;164(8):4135-42. 2000-04-15 [PMID: 10754308] (WB, Mouse)	WB	Mouse
Show All 234 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IF	Mouse	12/12/2014	View Summary Application Immunofluorescence Sample Tested testes Species Mouse
	5 reviewed by: Barbara Alcaraz Silva	IF	Other	10/08/2014	View Summary Application Immunofluorescence Sample Tested Mammalian Species Other Lot N-2
Enlarge	4 reviewed by: Svetlana Khoronenkova	IF	Human	07/31/2014	View Summary Application Immunofluorescence Sample Tested HeLa cells Species Human Lot no lot number on the tube
Enlarge	5 reviewed by: Svetlana Khoronenkova	WB	Human	04/10/2014	View Summary Application Western Blot Sample Tested TIG-1 human primary fibroblasts, whole cell lysate (30 ug) Species Human Lot no lot number on the tuve

Array NB100-142

• Mre11 Antibodies
• Mre11 Lysate
• Mre11 Proteins