CtIP Antibody

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-79810	Applications	Species
Chakraborty P, Hiom K DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination Nature communications 2021-07-05 [PMID: 34226554] (WB, ICC/IF)	WB, ICC/IF
Lee K Y, Im J. S, et al. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks. Mol Cell 2017-10-05 [PMID: 28943310] (WB)	WB
Lee KY, Im JS, Shibata E et al. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun. 2015-07-28 [PMID: 26215093] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Hu Y, Scully R, Sobhian B et al. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011-04-01 [PMID: 21406551]
Quennet V, Beucher A, Barton O et al CtIP and MRN promote non-homologous end-joining of EPE-induced DNA double-strand breaks in G1 Nucleic Acids Res 2011-03-01 [PMID: 21087997]

Array NB100-79810

• CtIP Antibodies
• CtIP Proteins