Leptin/OB Antibody

LEP is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 2 of 2.

Publications using NBP1-59324	Applications	Species
Zhang Y, Niu FX, Sun J et al. Purple sweet potato (Ipomoea batatas L.) color alleviates high-fat-diet-induced obesity in SD rat by mediating leptin's effect and attenuating oxidative stress. Food Science and Biotechnology. 2015-08-01 (Rat)		Rat
Fishman P, Cohen S, Itzhak I et al. The A3 adenosine receptor agonist, namodenoson, ameliorates non alcoholic steatohepatitis in mice Int. J. Mol. Med. 2019-10-03 [PMID: 31638172] (IHC-P, Mouse)	IHC-P	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Simple Western	Mouse	10/28/2016	View Summary Application Simple Western Sample Tested MIN6 cells transfected with plasmid expressing mouse leptin Species Mouse

Array NBP1-59324

• Leptin/OB Antibodies
• Leptin/OB Antibody Pair
• Leptin/OB ELISA Kits
• Leptin/OB Lysate
• Leptin/OB Protein
• Leptin/OB ELISAs
• Leptin/OB Proteins and Enzymes