PLOD1 Antibody

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-38770	Applications	Species
Koenig SN, Cavus O, Williams J Et al. New mechanistic insights to PLOD1-mediated human vascular disease Translational research : the journal of laboratory and clinical medicine 2021-08-13 [PMID: 34400365] (WB, IHC-P, Human)	WB, IHC-P	Human
Jover E, Silvente A, Marin F et al. Inhibition of enzymes involved in collagen cross-linking reduces vascular smooth muscle cell calcification. FASEB J. 2018-03-16 [PMID: 29547702] (Human)		Human
Heard ME, Besio R, Weis M et al. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS Genet. 2016-04-01 [PMID: 27119146] (WB, Mouse)	WB	Mouse

Array NBP2-38770

• PLOD1 Antibodies
• PLOD1 Proteins